|Table of Contents|

The curative effect of reconstructing and repairing bone defect with allogeneic bone graft after resection of malignant bone tumor of extremities

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 02
Page:
299-303
Research Field:
Publishing date:

Info

Title:
The curative effect of reconstructing and repairing bone defect with allogeneic bone graft after resection of malignant bone tumor of extremities
Author(s):
GAO Changcheng1; DU Xiaoping2
1.The Third Department of Orthopaedics and Traumatology;2.the First Department of Orthopaedics and Traumatology,Yulin Traditional Chinese Medicine Hospital,Shaanxi Yulin 719000,China.
Keywords:
malignant bone tumor; allogeneic bone graft; bone defect; tumor-type artificial joint replacement
PACS:
R738.1
DOI:
10.3969/j.issn.1672-4992.2022.02.025
Abstract:
Objective：To study the clinical effect of allogeneic bone graft in repairing and reconstructing bone defect after resection of malignant bone tumor in extremities.Methods:Fifteen patients underwent allogeneic bone graft reconstruction and nine patients underwent combined tumor-type artificial joint replacement were collected from March 2016 to August 2019 in our hospital with bone defect after resection of malignant bone tumor of extremities.All subjects in this article were confirmed by needle biopsy and postoperative pathology.There were 6 cases of stage Ⅰb and 18 cases of stage Ⅱb in Enneking stage.3 cases of Ewing's sarcoma and 15 cases of osteosarcoma were treated with 2 courses of chemotherapy and standard chemotherapy after operation.MSTS was used to evaluate the limb function of patients after operation.Results:All patients were followed up.The follow-up time was 8~46 months,with an average of (29.63±11.21) months.There were no fractures around the prosthesis or allograft fracture in 24 patients,and no prosthesis loosening or joint dislocation.Twenty patients had excellent postoperative limb function.The MSTS score was 16~28 points,with an average of (22.80±4.46) points.Conclusion:After the resection of malignant bone tumor of the extremities,the use of allogeneic bone graft to reconstruct the long bone defect and/or tumor-type artificial joint composite replacement for bone defect has significant clinical effects.

References:

[1]孔耀,卢路,郭洪敏,等.临床采用化疗联合外科保肢手术治疗骨肉瘤的远期预后分析［J］.中国保健营养,2019,29(6):32-33. KONG Yao,LU Lu,GUO Hongmin,et al.Long term prognosis of osteosarcoma treated by chemotherapy combined with limb salvage surgery［J］.China Health Nutrition,2019,29(6):32-33.
[2]丁丽,王婷玉.恶性肿瘤截肢患者生存质量评定研究进展［J］.中国基层医药,2015,22(17):2704-2706. DING Li,WANG Tingyu.Research progress on quality of life evaluation of amputated patients with malignant tumor［J］.China Basic Medicine,2015,22(17):2704-2706.
[3]徐敏,彭丹,彭红春,等.四肢恶性骨肿瘤保肢治疗的软组织修复及功能重建［J］.中南大学学报(医学版),2010,35(3):267-272. XU Min,PENG Dan,PENG Hongchun,et al.Soft tissue repair and functional reconstruction in limb salvage treatment of limb malignant bone tumors［J］.Journal of Central South University (Medical Edition),2010,35(3):267-272.
[4]袁昊龙,王志刚,张锴.Masquelet技术重建骨缺损研究进展［J］.中华骨科杂志,2018,38(21):1330. YUAN Haolong,WANG Zhigang,ZHANG Kai.Research progress on reconstruction of bone defect with masquelet technique［J］.Chinese Journal of Orthopedics,2018,38(21):1330.
[5]王骏,武壮壮,吕智.四肢骨肉瘤44例预后分析［J］.肿瘤研究与临床,2019,31(10):684-689. WANG Jun,WU Zhuangzhuang,LYU Zhi.Prognosis analysis of 44 cases of osteosarcoma of extremities［J］.Tumor Research and Clinical,2019,31(10):684-689.
[6]孙郁文,魏鹏,陈启旺,等.阿霉素结合骨修复材料应用于骨肉瘤治疗的研究进展［J］.实用骨科杂志,2019,25(8):728-733. SUN Yuwen,WEI Peng,CHEN Qiwang,et al.Research progress of adriamycin combined with bone repair materials in the treatment of osteosarcoma［J］.Journal of Practical Orthopedics,2019,25(8):728-733.
[7]任文涛,方策,高大柱,等.软组织修复重建在保肢治疗四肢恶性骨肿瘤的应用［J］.安徽卫生职业技术学院学报,2015,14(5):34-35,38. REN Wentao,FANG Ce,GAO Dazhu,et al.Application of soft tissue repair and reconstruction in limb salvage treatment of limb malignant bone tumor［J］.Journal of Anhui Health Vocational and Technical College,2015,14(5):34-35，38.
[8]郭卫.恶性骨肿瘤保肢治疗中存在的问题［J］.中华骨科杂志,2012,32(11):257-260. GUO Wei.Problems in limb salvage treatment of malignant bone tumors［J］.Chinese Journal of Orthopedics,2012,32(11):257-260.
[9]赵春和,黎海涛.恶性骨肿瘤保肢术临床应用的回眸与展望［J］.局解手术学杂志,2013,32(6):581-582. ZHAO Chunhe,LI Haitao.Review and prospect of limb salvage for malignant bone tumors［J］.Journal of Local Anatomy Surgery,2013,32(6):581-582.
[10]ZHANG C,HU J,ZHU K,et al.Survival,complications and functional outcomes of cemented megaprostheses for high-grade osteosarcoma around the knee［J］.International Orthopaedics,2018,42(4):927-938.
[11]HACKENBERG RK,NESSLER J,KNIG DP.First application of segmental trabecular metal cones in a custom-made revision tumor prosthesis of the knee:A technical note［J］.Technology & Health Care,2018,26(1):195-202.
[12]CRAIG R,VLYCHOU M,MCCARTHY CL,et al.Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma［J］.Springer Open Choice,2017,46(7):967-974.
[13]SAKELLARIOU VI,MAVROGENIS AF,BABIS GC,et al.Comparison of four reconstructive methods for diaphyseal defects of the humerus after tumor resection［J］.Journal of Applied Biomechanics,2012,28(5):568.
[14]WILSON RJ,SULIEMAN LM,VANHOUTEN JP,et al.Cost-utility of osteoarticular allograft versus endoprosthetic reconstruction for primary bone sarcoma of the knee:A markov analysis［J］.J Surg Oncol,2017,115(3):257-265.
[15]DA SFOG,OKADA OT,BACHEGA CLUDIA,et al.Reconstruction of alveolar cleft with allogenous bone graft:clinical considerations［J］.Dental Press Journal of Orthodontics,2014,18(6):138-147.
[16]JAMES C MELVILLE,NADER N NASSARI,ISSA A HANNA,et al.Immediate transoral allogeneic bone grafting for large mandibular defects.Less morbidity,more bone.A paradigm in benign tumor mandibular reconstruction［J］.Journal of Oral and Maxillofacial Surgery,2017,75(4):828-838.
[17]于爱文,王志强,苑秀华,等.异体骨-髌腱-骨移植物重建前交叉韧带的康复［J］.中华物理医学与康复杂志,2009,31(6):413-415. YU Aiwen,WANG Zhiqiang,YUAN Xiuhua,et al.Rehabilitation of anterior cruciate ligament reconstruction with allogeneic bone patellar tendon bone graft［J］.Chinese Journal of Physical Medicine and Rehabilitation,2009,31(6):413-415.
[18] 梁容瑞,李伟,赵晶,等.肿瘤相关性贫血患者血清促红细胞生成素水平与重组人促红细胞生成素治疗效果的关系［J］.中国老年学杂志,2015,22(22):6434-6436. LIANG Rongrui,LI Wei,ZHAO Jing,et al.Relationship between serum erythropoietin level and therapeutic effect of recombinant human erythropoietin in patients with tumor associated anemia［J］.Chinese Journal of Gerontology,2015,22(22):6434-6436.
[19] 官建中,周建生,周新社,等.冷冻保存带血管同种异体骨移植在儿童及青少年骨肉瘤保肢手术中的应用［J］.中国修复重建外科杂志,2015,29(10):1189-1193. GUAN Jianzhong,ZHOU Jiansheng,ZHOU Xinshe,et al.Application of cryopreserved vascularized allogeneic bone transplantation in limb salvage surgery for osteosarcoma in children and adolescents［J］.Chinese Journal of Repair and Reconstruction Surgery,2015,29(10):1189-1193.

Memo

Memo:
-
Last Update: 1900-01-01