|Table of Contents|

Tumor abnormal protein for the diagnosis of renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 02
Page:
278-281
Research Field:
Publishing date:

Info

Title:
Tumor abnormal protein for the diagnosis of renal cell carcinoma
Author(s):
JIANG Linjun; GAO Chao; AN Xiangchen; DONG Fengming; LIU Yili
The First Department of Urology,the Fourth Affiliated Hospital of China Medical University,Liaoning Shenyang 110032,China.
Keywords:
renal cell carcinoma; early diagnosis; tumor abnormal protein (TAP); biomarker
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2022.02.020
Abstract:
Objective：To study the value of tumor abnormal protein (TAP) expression in peripheral blood for diagnosis of early renal cell carcinoma.Methods:TAP expression was analyzed in the peripheral blood of 45 patients with renal cell carcinoma (carcinoma group),32 patients with benign renal lesions (benign group) and 42 healthy people (normal group).The receiver operating characteristics (ROC) curve was used to evaluate the diagnostic efficacy of TAP detection for renal cell carcinoma.An analysis of the relationship between TAP expression and the clinicopathological features in renal cell carcinoma was performed.Results:TAP levels were significantly higher in carcinoma group patients than that in benign group and normal group.To evaluate the diagnostic efficacy of TAP for renal cell carcinoma,the area under the ROC curve was 0.92 (95%CI:0.82~0.95),and the sensitivity and specificity in the diagnosis of renal cell carcinoma was 73% and 91%,respectively.Conclusion:The expression of TAP in peripheral blood of patients with renal cell carcinoma was significantly higher than that in nonneoplastic patients,which can be a tumor marker for early diagnosis of renal cell carcinoma.

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