|Table of Contents|

Analysis clinical and pathological features of recurrent breast phyllodes tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 02
Page:
242-245
Research Field:
Publishing date:

Info

Title:
Analysis clinical and pathological features of recurrent breast phyllodes tumors
Author(s):
TIAN Jie; ZHOU Donghua; PING Jing; QIN Yan; GE Juan
Department of Pathology,Maternal and Children's Hospital of Foshan，Guangdong Foshan 528000，China.
Keywords:
breast neoplasms; phyllodes tumor; recurrence; proliferation
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2022.02.013
Abstract:
Objective：To investigate the clinical and pathological features of recurrent phyllodes tumors.Methods:The cases of phyllodes tumors treated by surgery in our hospital from January 2011 to December 2019 were collected,and the recurrence cases were identified,then the clinical and histopathological features of the recurrence cases were analyzed.Results:137 cases of phyllodes tumors were collected,with a total of 10 cases of recurrence,including 9 cases recurred for once and 1 case for twice,in all of them,7 cases of benign phyllodes tumors,2 cases of borderline phyllodes tumors and 1 case of malignant phyllodes tumor.All tumors were local recurrence.The recurrence rates of benign,borderline and malignant tumors were 5.9%,15.4% and 20%,respectively.Histological progression occurred in 3 cases,1 case of benign phyllode tumor recurred to borderline phyllode tumor and 1 case of borderline phyllode tumor recurred to malignant phyllode tumor,1 case of benign phyllode tumor recurred to borderline phylloder tumor for the first time and malignant phyllode tumor for the second time.Immunohistochemical markers of CD117,CD34,CD10,p53,p16 showed no difference in expression between primary and recurrent tumors.The proliferation index of Ki67 recurred,and the number of mitotic increased.Conclusion:Benign,borderline or malignant phyllodes tumors may relapse,the recurrence rate of malignant phyllodes tumors is the highest,most of which are local recurrences,the proliferative activity of the tumor increased after recurrence.

References:

［1］GANESH V,DROST L,LEE J,et al.A retrospective review of phyllodes tumours of the breast:A single institution experience［J］.Breast,2018,38:52-57.
［2］ALLISON KH,BROGI E,ELLIS IO,et al.WHO classification of tumours of the breast ［M］.5th ed.Lyon:IARC Press,2019:172-176.
［3］TREVES N,SUNDERLAND D.Cystosarcoma phyllodes of the breast:A malignant and a benign tumor.A clinicopathological study of seventy:even cases［J］.Cancer,1951,4(6):1286-1332.
［4］TSE GM,NIU Y,SHI HJ.Phyllodes tumor of the breast:an update［J］.Breast Cancer,2010,17(1):29-34.
［5］贾翠,梅放,柳剑英,等.乳腺叶状肿瘤的分级指标及预后相关因素探讨［J］.中华病理学杂志,2017,46(1):14-19. JIA C,MEI F,LIU JY,et al.Histologic classification and prognosis factors in phyllodes tumors of breast［J］.Chinese Journal of Pathology,2017,46(1):14-19.
［6］TAN BY,ACS G,APPLE SK,et al.Phyllodes tumours of the breast:a consensus review［J］.Histopatholog,2016,68(1):5-21.
［7］张明迪,郑新宇.乳腺叶状肿瘤局部复发的临床风险因素分析［J］.中华乳腺病杂志(电子版),2012,06(3):17-21. ZHANG MD,ZHENG XY.Analysis on clinical risk factors of local recurrence in breast phyllode tumor［J］.Chinese Journal of Breast Disease (Electronic Version),2012,06(3):17-21.
［8］贾翠,梅放,郑杰,等.乳腺恶性叶状肿瘤的临床病理特点及预后分析［J］.中华病理学杂志,2013,42(11):729-734. JIA C,MEI F,ZHENG J,et al.Clinicopathologic features and prognostic factors of malignant phyllodes tumors［J］.Chinese Journal of Pathology,2013,42(11):729-734.
［9］FOUCHER T,ROUSSEL H,HIVELIN M,et al.Atypical distant metastasis of breast malignant phyllodes tumors:A case report and literature review［J］.Case Rep Obstet Gynecol,2017,11:1-6.
［10］YOSHIDAYA F,HAYASHI F,TAKAHASHI K,et al.Malignant phyllodes tumor metastasized to the right ventricle:a case report［J］.Surg Case Rep,2015,1(1):121-125.
［11］蒋娜,王鸿雁.乳腺恶性叶状肿瘤8例临床病理及预后分析［J］.诊断病理学杂志,2017,24(6):411-414. JIANG N,WANG HY.Malignant phyhodes tumors：clinicopathologic and prognostic analyses of 8 cases［J］.Chinese Journal of Diagnostic Pathology,2017,24(6):411-414.
［12］BARRIO AV,CLARK BD,GOLDBERG JI,et al.Clinicopathologic features and long-term outcomes of 293 phyllodes tumors of the breast［J］.Annals of Surgical Oncology,2007,14(10):2961-2970.
［13］ZHANG Y,KLEER CG.Phyllodes tumor of the breast:histopathologic features,differential diagnosis,and molecular/genetic updates［J］.Arch Pathol Lab Med,2016,140(7):665-671.
［14］JONES AM,MITTER R,SPRINGALL R,et al.A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations,intra-tumoral genetic heterogeneity and new genetic changes on recurrence［J］.J Pathol,2008,214(5):533-544.
［15］刘宇琼,张敏,黄会粉,等.CD34、CD10、CD117在乳腺叶状肿瘤病理诊断中的作用［J］.肿瘤基础与临床,2018,31(6):535-537. LIU YQ,ZHANG M,HUANG HF,et al.The role of CD34,CD10 and CD117 in the pathological diagnosis of phyhodes breast tumors［J］.Journal of Basic and Clinical Oncology,2018,31(6):535-537.
［16］NIEZABITOWSKI A,LACKOWSKA B,RYS J,et al.Prognostic evaluation of proliferative activity and DNA content in the phyllodes tumor of the breast:immunohistochemical and flow cytometric study of 118 cases［J］.Breast Cancer Res Treat,2001,65(1):77-85.
［17］TSE GM,LUI PC,VONG JS,et al.Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors［J］.Breast Cancer Res Treat,2009,114(3):441-448.
［18］BRETONES G,DELGADO MD,LEN J.Myc and cell cycle control［J］.Biochim Biophys Acta,2015,1849(5):506-516.

Memo

Memo:
-
Last Update: 1900-01-01