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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2021 05

Page:

901-906

Research Field:

Publishing date:

Info

Title:

Advance of Notch signaling pathway regulating cell apoptosis in malignant tumor

Author(s):

WU Zhen¹; HU Yanjian²; YIN Qi¹; HU Yanhua¹

1.Department of General Surgery,the Second Affiliated Hospital of Harbin Medical University£¬Heilongjiang Harbin 150086£¬China;2.Department of Gastroenterology and Hepatology,Harbin First Hospital of Affiliated to Harbin Institute of Technology£¬Heilongjiang Harbin 150010£¬China.

Keywords:

Notch signaling pathway; malignant tumor cell; apoptosis; mechanism

PACS:

R730

DOI:

10.3969/j.issn.1672-4992.2021.05.041

Abstract:

Notch signaling pathway is a highly evolutionarily conserved signaling pathway,which plays a key role in a wide array of cellular processes including proliferation,differentiation,and apoptosis.Recently,we have known the receptor,ligand,and transduction process of Notch signaling pathway,and also made significant progress in research of Notch signaling pathway regulating apoptosis in malignant tumor.This overview is on currently novel advances about the role and mechanism of Notch signaling pathway in hematological and solid malignancy cell apoptosis.The focus of this article will review the highly context dependent nature of the Notch signaling pathway in various subtype cell,and the effect of cross-talk between Notch signaling pathway and other signaling pathway regulating apoptosis in malignant tumor.

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