|Table of Contents|

The expression of microRNA Let-7 in uterine fibroids and the risk factors related to recurrence

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 05
Page:
848-851
Research Field:
Publishing date:

Info

Title:
The expression of microRNA Let-7 in uterine fibroids and the risk factors related to recurrence
Author(s):
LIU Peili1; ZHANG Yajun2; JIANG Xin2
1.Department of Gynecology;2.Department of Pathology，Lianyungang Maternity and Child Care Hospital，Jiangsu Lianyungang 222000,China.
Keywords:
single myoma; multiple myoma; diameter of myoma; miRNA Let7
PACS:
R737.33
DOI:
DOI:10.3969/j.issn.1672-4992.2021.05.028
Abstract:
Objective:To investigate the expression levels of microRNA Let-7 in tissues of uterine myoma and surrounding normal myometriumin,all cases were classified into different groups according to the number or diameter of myomas,then analyze the relations between microRNA Let-7 and risk factors of myoma recurrence.Methods:The microRNA let-7 expression levels in uterine myoma and surrounding normal myometrium in tissues were detected by quantitative real-time PCR from groups of single or multiple uterine myoma,larger myomas(diameter≥5 cm) or smaller myomas(diameter＜5 cm).Results:The expression levels of microRNA let-7 in myoma tissues were slightly weaker than that of surrounding normal myometriumin,but the difference was not significant(P＞0.05).Then the expression levels of microRNA let-7 in groups of single myoma and smaller myoma(diameter＜5 cm) were higher than of multiple myoma and larger myoma(diameter≥5 cm),and the difference was statistically significant(P＜0.01).Conclusion:The number and diameter of myomas are independently risks of recurrence.MicroRNA Let-7 with higher expression in multiple myoma and larger myoma is expected to be an new marker for myoma recurrence．

References:

［1］石一复.子宫肌瘤患者再生育风险及处理［J］.中国计划生育和妇产科，2017，9（5）：8-10. SHI YF.Risks and managements of reproduction in patients with uterine fibroids ［J］.Chinese Journal of Family Planning & Gynecotokology,2017,9(5):8-10.
[2]STEWART EA，COOKSON CL，GANDOLFO RA，et al.Epidemiology of uterinefibroids:A systematic review［J］.BJOG-An International Journal of Obstetrics and Gynaecology，2017，124( 10):1501-1512．
[3]李慧玲,贾雪菲.子宫肌瘤剔除术后肌瘤复发相关危险因素的分析［J］.实用妇科内分泌电子杂志,2019,6(17):39-46. LI HL,JIA XF.Analysis of risk factors related to recurrence of uterine fibroids after myomectomy ［J］.Electronic Journal of Practical Gynecologic Endocrinology,2019,6(17):39-46.
[4]蔡兴苑,卢丹,魏薇,等.子宫肌瘤剔除术后复发情况及相关危险因素分析［J］.实用妇产科杂志,2015,31(05):358-360. CAI XY,LU D,WEI W，et al.Analysis of recurrence and related risk factors after myomectomy ［J］.Journal of Practical Obstetrics and Gynecology,2015,31(05):358-360.
[5]AL-ERYANI L,SF JENKINS,VA STATES,et al.miRNA expression profiles of premalignant and malignant arsenic-induced skin lesions［J］.PLoS One,2018,13(8):e0202579.
[6]ARMAND-LABIT V,PRADINES A.Circulating cell-free microRNAs as clinical cancer biomarkers［J］.Biomolecular Concepts,2017,8(2)61-81.
[7]VANNINI I,FANINI F,FABBRI M.Emerging roles of microRNAs in cancer［J］.Current Opinion in Geneti Dev,2018(48):128-133.
[8]CHIEN CS,WANG ML,CHU PY,et al．Lin28B/Let-7 regulares expression of Oct4 and Sox2 and reprograms oral squamous ce11 carcinoma cells to a stem-like state［J］．Cancer Res，2015，75(12)：2553-2565．
[9]CHEN CC,YOU JY,LUNG J,et al.Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms［J］.Haematologica,2017,102(3):509-518.
[10]PENG Y,LASER J,SHI G,et al.Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma［J］.Mol Cancer Res,2008,6(4):663-673.
[11]HUANG YM,LI WW,WU J,et al.The diagnostic value of circulating microRNAs in heart failure［J］.Exp Ther Med,2019,17(3):1985-2003.
[12]QU TT,CHEN F,WANG J,et al.PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells ［J］.BMC Cancer,2018,21(27):1-8.
[13]DONG HY,HUANG ZC,ZHANG HL,et al.Rs13293512 polymorphism located in the promoter region of let-7 is associated with increased risk of radiation enteritis in colorectal cancer［J］.J Cell Biochem,2018,119(8):6535-6544.
[14]SIRI AT,MALENE BH,KNUT KB,et al.Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zincfinger-1［J］.Oncogenesis,2018,7(2):14.
[15]MEHINE M，KAASINEN E，HEINONEN HR，et al．Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers［J］.Proc Natl Acad Sci USA,2016,113(5):1315-1320．
[16]周红菊.子宫肌壁间平滑肌瘤行肌瘤剔除术后复发相关危险因素分析［J］.现代肿瘤医学,2018,26(19):3103-3105. ZHOU HJ.The risk factors of recurrence of intramural leiomyoma were analyzed after myomectomy［J］.Modern Oncology,2018,26(19):3103-3105.
[17]BULUN SE.Uterine fibroids［J］.N Engl J Med,2013,369(14):1344-1355．

Memo

Memo:
江苏省妇幼健康科研项目（编号:F201659）；连云港市卫生计生科技项目（编号:201622）
Last Update: 2021-01-29