|Table of Contents|

The correlation between expression of COX-2 and microvessel density in ovary serous carcinomas

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 05
Page:
844-847
Research Field:
Publishing date:

Info

Title:
The correlation between expression of COX-2 and microvessel density in ovary serous carcinomas
Author(s):
GAO Xiao1; WU Hongpei2; LIU Juanni3; LIU Liying4; YANG Xuechao1
1.Department of Pathology;3.Department of Oncology;4 Department of Gynecology,No.215 Hospital of Shaanxi Nuclear Industry,Shaanxi Xianyang 712000,China;2.Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine，Shaanxi Xianyang 712000,China.
Keywords:
ovary serous carcinomas; COX-2; MVD
PACS:
R737.31
DOI:
DOI:10.3969/j.issn.1672-4992.2021.05.027
Abstract:
Objective:To explore the relationship between COX-2 expression and microvessel density（MVD）of ovary serous carcinomas.Methods:The expression of COX-2 and CD34 in 94 cases of ovarian serous carcinoma was detected by SP immunohistochemical staining,and the correlation between COX-2 expression and MVD was analyzed.Results:There were 56 cases of COX-2 positive and 38 cases of COX-2 negative expression in ovarian serous carcinoma.The median value of MVD in 94 patients with ovarian serous carcinoma was 34.33,which was divided into two groups,high MVD group (44 cases) and low MVD group (50 cases).In high MVD group,the median survival time was 16 months,3-year survival rate was 54.55%,5-year survival rate was 27.27%,and in low MVD group,the median survival time was 38 months,3-year survival rate was 78.00%,5-year survival rate was 62.00%.There was a significant difference in prognosis between the two groups (P＜0.05).The expression of COX-2 was positively correlated with MVD (P＜0.05).Conclusion:COX-2 expression in ovarian serous carcinoma is related to neovascularization,which can promote the occurrence and development of tumor.

References:

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Last Update: 2021-01-29