|Table of Contents|

Expression of transgelin and trasngelin2 in colorectal carcinoma and its prognosis significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 05
Page:
823-828
Research Field:
Publishing date:

Info

Title:
Expression of transgelin and trasngelin2 in colorectal carcinoma and its prognosis significance
Author(s):
CHEN Yu1; CUI Facai2; SONG Wei1; WANG Jiaqi1; XIA Qingxin1
1.Department of Pathology,Affiliated Tumor Hospital of Zhengzhou University,Henan Zhengzhou 450008,China;2.Clinical Laboratory,Henan Province People's Hospital,Henan Zhengzhou 450003,China.
Keywords:
transgelin; transgelin2; colorectal carcinoma; prognosis
PACS:
R735+5
DOI:
DOI:10.3969/j.issn.1672-4992.2021.05.022
Abstract:
Objective:To investigate the relationship of transgelin (TAGLN) and transgelin 2 (TAGLN2) expression in colorectal carcinoma tissues and the clinical pathological characteristics and prognosis of the patients.Methods:Eighty-nine cases of colorectal cancer surgical resection samples were collected from 2012 to 2013 in Affiliated Tumor Hospital of Zhengzhou University.The expression of TAGLN and TAGLN2 was assessed by immunohistochemistry.The relationship between TAGLN,TAGLN2 and clinicopathological features and prognosis of CRC patients combined the clinical data.Results:The positive expression rate of TAGLN in colorectal cancer tissues was 60.7%(54/89),which was significantly higher than 38.2%(34/89) in adjacent tissues,with statistically significant differences (P＜0.05),and the expression of TAGLN was related to TNM staging,tumor differentiation,Ki67,lymph node metastasis and distant metastasis(all P＜0.05).The positive expression rate of TAGLN2 in colorectal cancer tissues was 69.7%(62/89),significantly higher than that in adjacent tissues 31.5%(28/89),and the difference was statistically significant(P＜0.01),and the expression of TAGLN2 was significantly correlated with the degree of tumor differentiation,Ki67 and distant metastasis in colorectal cancer patients (all P＜0.05).The correlation analysis showed that the expressions of TAGLN was positively correlated with TAGLN2 (r=0.219,P=0.039).Kaplan-meier survival analysis showed that the survival time was related to tumor differentiation,TNM stage,Ki67,distant metastasis and the expression of TAGLN and TAGLN2 (all P＜0.05).Cox multivariate analysis showed that TNM stage,distant metastasis,TAGLN were independent factors influencing the prognosis of colorectal cancer patients (all P＜0.05).Conclusion:To CRC patients,the expression of TAGLN is associated with TNM stage,tumor differentiation,Ki67,lymph node metastasis and distant metastasis while TAGLN2 is associated with tumor differentiation,Ki67 and distant metastasis.TNM stage,distant metastasis and TAGLN were independent prognostic factors in CRC patients.

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Memo

Memo:
河南省医学科技攻关计划项目(编号：201702246)
Last Update: 2021-01-29