|Table of Contents|

Expression and significance of HGF,c-Met and p-Erk in gastric cancer tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 05
Page:
819-823
Research Field:
Publishing date:

Info

Title:
Expression and significance of HGF,c-Met and p-Erk in gastric cancer tissues
Author(s):
HOU Taotao; ZHANG Jianfeng; LEI Shirui; JIANG Chenggang
Department of Surgical Oncology and General Surgery,Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors,Ministry of Education,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China.
Keywords:
gastric cancer; HGF; c-Met; p-Erk; immunohistochemistry
PACS:
R735.2
DOI:
DOI:10.3969/j.issn.1672-4992.2021.05.021
Abstract:
Objective:To investigate the relationship of hepatocyte growth factor(HGF),mesenchymal epithelial transition factor(c-Met),phosphorylated Erk(p-Erk) expression and clinicopathology characteristics of gastric cancer.To investigate whether HGF,c-Met,and p-Erk expressions have a significant effect on the survival of patients with gastric cancer.Methods:The expression of HGF,c-Met and p-Erk in 71 cases of gastric cancer and 53 cases of adjacent normal tissues were detected by immunohistochemistry.The relationship between HGF,c-Met and p-Erk was analyzed.The correlation betweenthe expression in gastric cancer tissues and clinicopathology characteristics was also analyzed,and then the survival rate of five years was calculated.Results:The expression of HGF,c-Met and p-Erk in gastric cancer tissues was significantly higher than that in adjacent normal tissues (P＜0.05).The expression of them in gastric cancer tissues were not related to gender,age,main cancer location,differentiation(P＞0.05),but were significantly related with the main cancer size,pathological tissue growth pattern，depth of invasion,lymph node metastasis,and recurrence or metastasis (P＜0.05).In gastric cancer tissues,p-Erk was positively correlated with HGF expression (r=0.666,P=0.003),and p-Erk was positively correlated with c-Met expression (r=0.587,P=0.001).The expression of c-Met was positively correlated with HGF expression(r=0.576,P=0.001).The positive expression of HGF,c-Met and p-Erk significantly lowered survival rate of five years.Conclusion：The expression of HGF,c-Met and p-Erk were significantly increased in gastric cancer tissues.They were closely related to the occurrence and development of gastric cancer,and might participate in the process of gastric cancer.

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Memo

Memo:
辽宁省科技厅一般项目（编号：LK201623）
Last Update: 2021-01-29