[1] SIEGEL RL,MILLER KD,JEMAL A.Cancer statistics,2020[J].CA Cancer J Clin,2020,70(1):7-30.
[2] 陈万青,孙可欣,郑荣寿,等.2014年中国分地区恶性肿瘤发病和死亡分析[J].中国肿瘤,2018,27(01):1-14.
CHEN WQ,SUN KX,ZHENG RS,et al.Analysis on incidence and death of malignant tumors in different regions of China in 2014[J].China Tumor,2018,27(01):1-14.
[3] 孙可欣,郑荣寿,张思维,等.2015年中国分地区恶性肿瘤发病和死亡分析[J].中国肿瘤,2019,28(01):1-11.
SUN KX,ZHENG RS,ZHANG SW,et al.Analysis on incidence and death of malignant tumors in different regions of China in 2015[J].China Tumor,2019,28(01):1-11.
[4] BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[5] ZHAO S,LI H,WANG Q,et al.The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated alpha2M[J].BMC Cancer,2015,15:389.
[6] YIN Y,CHEN C,CHEN J,et al.Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR[J].Cell Signal,2017,35:154-162.
[7] YAO X,LIU H,ZHANG X,et al.Cell surface GRP78 accelerated breast cancer cell proliferation and migration by activating STAT3[J].PLoS One,2015,10(5):e125634.
[8] ZHANG Y,TSENG CC,TSAI YL,et al.Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production[J].PLoS One,2013,8(11):e80071.
[9] FU R,YANG P,WU HL,et al.GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling[J].Asian Pac J Cancer Prev,2014,15(17):7245-7249.
[10] JIANG B,ZHANG R,ZHANG J,et al.GRP78-targeted ferritin nanocaged ultra-high dose of doxorubicin for hepatocellular carcinoma therapy[J].Theranostics,2019,9(8):2167-2182.
[11] LEE AS.Glucose-regulated proteins in cancer:molecular mechanisms and therapeutic potential[J].Nat Rev Cancer,2014,14(4):263-276.
[12] BROCCHIERI L,CONWAY DME,MACARIO AJ.hsp70 genes in the human genome:Conservation and differentiation patterns predict a wide array of overlapping and specialized functions[J].BMC Evol Biol,2008,8:19.
[13] WANG J,LEE J,LIEM D,et al.HSPA5 gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum[J].Gene,2017,618:14-23.
[14] 申龙健,殷香宇,孔迪,等.内质网应激与细胞死亡[J].神经损伤与功能重建.2015,10(03):230-232.
SHEN LJ,YIN XY,KONG D,et al.Endoplasmic reticulum stress and cell death [J].Nerve damage and functional reconstruction,2015,10(03):230-232.
[15] RUBIO-PATINO C,BOSSOWSKI JP,CHEVET E,et al.Reshaping the immune tumor microenvironment through IRE1 signaling[J].Trends Mol Med,2018,24(7):607-614.
[16] SO JS.Roles of endoplasmic reticulum stress in immune responses[J].Mol Cells,2018,41(8):705-716.
[17] BAILLY C,WARING MJ.Pharmacological effectors of GRP78 chaperone in cancers[J].Biochem Pharmacol,2019,163:269-278.
[18] CLARKE WR,AMUNDADOTTIR L,JAMES MA.CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells[J].Int J Cancer,2019,144(6):1367-1378.
[19] TSAI YL,ZHANG Y,TSENG CC,et al.Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface[J].J Biol Chem,2015,290(13):8049-8064.
[20] TSAI YL,HA DP,ZHAO H,et al.Endoplasmic reticulum stress activates SRC,relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-beta signaling[J].Proc Natl Acad Sci USA,2018,115(18):E4245-E4254.
[21] LIMSO C,NGO JM,NGUYEN P,et al.The Gα‐interacting vesicle‐associated protein interacts with and promotes cell surface localization of GRP78 during endoplasmic reticulum stress[J].FEBS Letters,2020,594(6):1088-1100.
[22] TSENG CC,ZHANG P,LEE AS.The COOH-terminal proline-rich region of GRP78 is a key regulator of its cell surface expression and viability of tamoxifen-resistant breast cancer cells[J].Neoplasia,2019,21(8):837-848.
[23] LI Z,ZHANG L,ZHAO Y,et al.Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion[J].Int J Biochem Cell Biol,2013,45(5):987-994.
[24] AL-HASHIMI AA,LEBEAU P,MAJEED F,et al.Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor[J].J Biol Chem,2017,292(51):21180-21192.
[25] 孙翠翠,张斯萌,温倜,等.晚期非小细胞肺癌肿瘤生长速率与临床病理特征及预后的相关性[J].中国医科大学学报,2019,48(08):673-677.
SUN CC,ZHANG SM,WEN T,et al.Correlation between tumor growth rate and clinicopathological features and prognosis in advanced non-small cell lung cancer[J].Journal of China Medical University,2019,48(08):673-677.
[26] KANG BR,YANG SH,CHUNG BR,et al.Cell surface GRP78 as a biomarker and target for suppressing glioma cells[J].Sci Rep,2016,6:34922.
[27] GONZALEZ-GRONOW M,GOMEZ CF,DE RIDDER GG,et al.Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro[J].J Biol Chem,2014,289(36):25166-25176.
[28] ZHANG XX,LI HD,ZHAO S,et al.The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells[J].Biomed Res Int,2013,2013:917296.
[29] 贺武斌.细胞表面GRP78与CRAF作用增加肝癌细胞对索拉非尼耐药性的研究[D].辽宁:锦州医科大学,2016.
HE WB.Cell surface GRP78 interacts with CRAF to increase sorafenib resistance in hepatocellular carcinoma cells [D].Liaoning:Jinzhou Medical University,2016.
[30] LIU R,LI X,GAO W,et al.Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling,tumor growth,and metastasis[J].Clin Cancer Res,2013,19(24):6802-6811.
[31] JIAN Q,YANG Z,SHU J,et al.Lectin BS-I inhibits cell migration and invasion via AKT/GSK-3beta/beta-catenin pathway in hepatocellular carcinoma[J].J Cell Mol Med,2018,22(1):315-329.
[32] LI Z,ZHAO C,LI Z,et al.Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer[J].Int J Biochem Cell Biol,2014,47:68-75.
[33] KAO C,CHANDNA R,GHODE A,et al.Proapoptotic cyclic peptide BC71 targets cell-surface GRP78 and functions as an anticancer therapeutic in mice[J].EBioMedicine,2018,33:22-32.
[34] GONG C,HU X,XU Y,et al.Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78[J].Anticancer Drugs,2020,31(2):141-149.
[35] GOPAL U,MOWERY Y,YOUNG K,et al.Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling[J].J Biol Chem,2019,294(38):13939-13952.
[36] DADEY D,KAPOOR V,HOYE K,et al.Antibody targeting GRP78 enhances the efficacy of radiation therapy in human glioblastoma and non-small cell lung cancer cell lines and tumor models[J].Clin Cancer Res,2017,23(10):2556-2564.