[1] CALLIER V.Core concept:Solving peto's paradox to better understand cancer[J].Proc Natl Acad Sci USA,2019,116(6):1825-1828.
[2] GOTWALS P,CAMERON S,CIPOLLETTA D,et al.Prospects for combining targeted and conventional cancer therapy with immunotherapy[J].Nat Rev Cancer,2017,17(5):286-301.
[3] CUI R,MODEIROS T,WILLEMSEN D,et al.Relaxed selection limits lifespan by increasing mutation load [J].Cell,2019,178(2):385-399.
[4] ROZHOK AI,DEGREGORI J.Toward an evolutionary model of cancer:Considering the mechanisms that govern the fate of somatic mutations[J].Proc Natl Acad Sci USA,2015,112(29):8914-8921.
[5] MADAN E,PELHAM CJ,NAGANE M,et al.Flower isoforms promote competitive growth in cancer[J].Nature,2019,572(7768):260-264.
[6] MADHUSOODANAN J.News feature:Do hosts and their microbes evolve as a unit [J].PNAS,2019,116(29):14391-14394.
[7] PICH O,MUINOS F,SABARINATHAN R,REYES-SALAZAR I,et al.Somatic and germline mutation periodicity follow the orientation of the DNA minor groove around nucleosomes[J].Cell,2018,175(4):1074-1087.e18.
[8] KAZAZIAN HH JR,MORAN JV.Mobile DNA in health and disease[J].N Engl J Med,2017,377(4):361-370.
[9] KAUFMAN CK,MOSIMANN C,FAN ZP,et al.A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation [J].Science,2016,351(6272):aad2197.
[10] GREAVES M.When one mutation is all it takes[J].Cancer Cell,2015,27(4):433-434.
[11] SOTTORIVA A,KANG H,MA Z,et al.A Big Bang model of human colorectal tumor growth [J].Nat Genet,2015,47(3):209-216.
[12] ROZHOK AI,DEGREGORI J.The evolution of lifespan and age-dependent cancer risk[J].Trends Cancer,2016,2(10):552-560.
[13] 张百红,岳红云.肿瘤状态的改变[J].西北国防医学杂志,2016,37(4):261-264.
ZHANG BH,YUE HY.Changes of cancer status before and after therapy[J].Med J NDFNC,2016,37(4):261-264.
[14] FILLON M.Low-cost online cascade test may persuade relatives to investigate their own cancer risk[J].CA Cancer J Clin,2019,69(2):86-87.
[15] LANDHUIS E.Science and culture:Cancer researcher looks to artists for inspiration[J].Proc Natl Acad Sci USA,2018,115(5):826-827.
[16] LAZARIS C,AIFANTIS I,TSIRIGOS A.On epigenetic plasticity and genome topology[J].Trends Cancer,2020,6(3):177-180.
[17] FAIS S,OVERHOLTZER M.Cell-in-cell phenomena in cancer[J].Nat Rev Cancer,2018,18(12):758-766.
[18] ONDECK MG,KUMAR A,PLACONE JK,et al.Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling[J].Proc Natl Acad Sci USA,2019,116(9):3502-3507.
[19] SHURER CR,KUO JC,ROBERTS LM,et al.Physical principles of membrane shape regulation by the glycocalyx[J].Cell,2019,177(7):1757-1770.
[20] MOHAMMADI H,SAHAI E.Mechanisms and impact of altered tumour mechanics[J].Nat Cell Biol,2018,20(7):766-774.
[21] BALANI S,NGUYEN LV,EAVES CJ.Modeling the process of human tumorigenesis[J].Nat Commun,2017,8:15422.
[22] FINN EH,PEGORARO G,BRANDAO HB.Extensive heterogeneity and intrinsic variation in spatial genome organization[J].Cell,2019,176(6):1502-1515.
[23] MATTEO LIGORIO,SRINJOY SIL,JOSE MALAGON-LOPEZ.Stromal microenvironment shapes the intratumoral architecture of pancreatic cancer[J].Cell,2019,178(1):160-175.
[24] BHATT AP,REDINBO MR,BULTMAN SJ.The role of the microbiome in cancer development and therapy[J].CA Cancer J Clin,2017,67(4):326-344.
[25] MALLET DE LIMA CD,GONAOR A.Circadian organization of the genome[J].Science,2018,359(6381):1212-1213.
[26] PANDA S.Circadian physiology of metabolism[J].Science,2016,354(6315):1008-1015.
[27] MAN K,LOUDON A,CHAWLA A.Immunity around the clock[J].Science,2016,354(6315):999-1003.
[28] HORVATH S,RAJ K.DNA methylation-based biomarkers and the epigenetic clock theory of ageing[J].Nat Rev Genet,2018,19(6):371-384.
[29] OLSHANSKY SJ.Ageing:Measuring our narrow strip of life[J].Nature,2016,538(7624):175-176.
[30] GARON EB,HELLMANN MD,RIZVI NA,et al.Five-year overall survival for patients with advanced non-small-cell lung cancer treated with pembrolizumab:Results from the phase I KEYNOTE-001 study[J].J Clin Oncol,2019,37(28):2518-2527.
[31] IM SA,LU YS,BARDIA A,et al.Overall survival with ribociclib plus endocrine therapy in breast cancer[J].N Engl J Med,2019,381(4):307-316.
[32] MCGRANAHAN N,SWANTON C.Clonal heterogeneity and tumor evolution:Past,present,and the future[J].Cell,2017,168(4):613-628.
[33] FEINBERG AP.The Key role of epigenetics in human disease prevention and mitigation[J].N Engl J Med,2018,378(14):1323-1334.
[34] SAOTOME K,MURTHY SE,KEFAUVER JM,et al.Structure of the mechanically activated ion channel Piezo1[J].Nature,2018,554(7693):481-486.
[35] PAN Y,YOON S,SUN J,et al.Mechanogenetics for the remote and noninvasive control of cancer immunotherapy[J].Proc Natl Acad Sci USA,2018,115(5):992-997.
[36] GOMEZ JL,BONAVENTURA J,LESNIAK W,et al.Chemogenetics revealed:DREADD occupancy and activation via converted clozapine[J].Science,2017,357(6350):503-507.
[37] MENARD C,RUSSO SJ.Non-invasive chemogenetics[J].Nature Biomedical Engineering,2019,2:467-468.
[38] 张百红,岳红云.肿瘤的光遗传学治疗[J].肿瘤防治研究,2018,45(12):1023-1026.
ZHANG BH,YUE HY.Optogenetics therapy of human cancers[J].Cancer Res Prev Treat,2018,45(12):1023-1026.
[39] BAILEY SR,MAUS MV.Gene editing for immune cell therapies[J].Nat Biotechnol,2019,37(12):1425-1434.
[40] PANDA S.The arrival of circadian medicine[J].Nat Rev Endocrinol,2019,15(2):67-69.
[41] EL-DEIRY WS,GOLDBERG RM,LENZ HJ,et al.The current state of molecular testing in the treatment of patients with solid tumors,2019[J].CA Cancer J Clin,2019,69(4):305-343.
[42] ADAM D.How a data detective exposed suspicious medical trials[J].Nature,2019,571(7766):462-464.
[43] MOK TS,CHENG Y,ZHOU X,et al.Improvement in overall survival in a randomized study that compared dacomitinib with gefitinib in patients with advanced non-small-cell lung cancer and EGFR-activating mutations[J].J Clin Oncol,2018,36(22):2244-2250.
[44] SANMAMED MF,CHEN L.A Paradigm shift in cancer immunotherapy:from enhancement to normalization [J].Cell,2018,175(2):313-326.
[45] ZHANG S,SCOTT EY,SINGH J,et al.The optoelectronic microrobot:A versatile toolbox for micromanipulation[J].Proc Natl Acad Sci USA,2019,116(30):14823-14828.