|Table of Contents|

The expression and correlation of Bmi-1 and C-myc in endometrioid adenocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 04
Page:
671-675
Research Field:
Publishing date:

Info

Title:
The expression and correlation of Bmi-1 and C-myc in endometrioid adenocarcinoma
Author(s):
QIN Rui1; GAN Jinghua1; DU Yangjun1; CHEN Xiao1; MO Qiurong2; LIANG Yuncai2; NONG Wenzheng1
1.Department of Gynaecology,The Guangxi National Hospital Affiliated to Guangxi Medical University,Guangxi Nanning 530001，China;2.Department of Pathology,The People's Hospital of Chongzuo,Guangxi Chongzuo 532200,China.
Keywords:
Bmi-1; C-myc; atypical hyperplasia of endometrium; endometrioid adenocarcinoma
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2021.04.028
Abstract:
Objective：To explore the expressions of Bmi-1 protein and C-myc in the endometrioid adenocarcinoma and atypical hyperplasia of endometrium.Methods:Immunohistochemistrical methods was used to explore the expressions of Bmi-1 protein and C-myc in 90 cases of endometrioid adenocarcinoma and 40 cases of atypical hyperplasia of endometrium.Results:The postive rate of Bmi-1 protein in the endometrioid adenocarcinoma and atypical hyperplasia were 83.3% and 55%，respctively.The postive rate of C-myc in the endometrioid adenocarcinoma and atypical hyperplasia of endometrium were 78.9% and 72.5%，respectively.In the endometrioid adenocarcinoma,the expression of Bmi-1 and C-myc were associated with histologic grade,invasion depth,vascular invasion,estrogen receptor α and progesterone receptor,respectively.The difference was statistically significant（P＜0.05）.There was positive correlation between the expression of Bmi-1 protein and that of C-myc（r=0.029,P=0.006).Conclusion:Bmi-1 and C-myc protein may cooperate with each other in the occurrence and development of endometrioid adenocarcinoma.The combined detection of Bmi-1 and C-myc is of certain value in the early diagnosis and development of endometrioid adenocarcinoma.

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Memo

Memo:
广西壮族自治区卫健委科研课题（编号：Z20180611）；崇左市科研项目课题（编号：崇科攻2019023）
Last Update: 1900-01-01