|Table of Contents|

Expression characteristics and clinical significance of HMGB1 in gastric cancer:A Meta-analysis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 04
Page:
620-626
Research Field:
Publishing date:

Info

Title:
Expression characteristics and clinical significance of HMGB1 in gastric cancer:A Meta-analysis
Author(s):
ZHANG Wen1; 2; SUN Mingyang3; JIAO Ruonan2; WANG Huishan2; WANG Yuting2; TANG Ruiyi2; NIE Junjie2; MIAO Lin2
1.the Affiliated Wuxi People's Hospital of Nanjing Medical University,Jiangsu Wuxi 214000,China;2.Medical Center for Digestive Diseases,the Second Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210000,China;3.Department of General Surge
Keywords:
HMGB1 protein; stomach neoplasms; neoplasm metastasis; cell differentiation; Meta-analysis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2021.04.016
Abstract:
Objective：To clarify the expression of HMGB1 and its relationship with clinical features of gastric cancer.Methods:Multiple databases were systematically searched for relevant studies from 1997 to 2019.We screened case-control studies stating that the association between HMGB1 protein expression and clinical characteristics in gastric cancer.Results:In total,eight independent studies with 872 patients were included.Meta-analysis indicated higher odds of HMGB1 being present in gastric tumor tissues compared to para-tumor controls［OR=4.15,95%CI:3.09~5.58,P＜0.01］.High HMGB1 expression was also associated with poor differentiation rate ［OR=0.73，95%CI:0.54~0.99，P=0.04］,TNM stages Ⅲ-Ⅳ［OR=0.28,95%CI:0.18~0.44,P＜0.01］,lymphatic metastasis ［OR=2.08,95%CI:1.52~2.84,P＜0.01］ and diffuse type of Lauren classification［OR=0.57,95%CI:0.38~0.84,P＜0.01］.However,there was no significant correlation between HMGB1 expression and gender and age.Conclusion:Our results illustrated that HMGB1 protein was strongly associated with adverse clinicopathological features of gastric cancer.HMGB1 may be a promising target in the development of gastric cancer.

References:

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江苏省“科教强卫工程”重点人才项目(编号：ZDRCA2016034)
Last Update: 1900-01-01