|Table of Contents|

Evaluation of the effect of amounts of sterile water for injection for celiac irrigation in laparoscopic treatment of local advanced adenocarcinoma of esophagogastric junction

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 04
Page:
604-609
Research Field:
Publishing date:

Info

Title:
Evaluation of the effect of amounts of sterile water for injection for celiac irrigation in laparoscopic treatment of local advanced adenocarcinoma of esophagogastric junction
Author(s):
DU Ning1; LI Kai1; PENG Ziyang1; HU Xiayun1; LIAO Xinhua2; SUN Xin1; REN Hong1; LIU Dapeng1
1.Department of Thoracic Surgery;2.Department of General Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China.
Keywords:
adenocarcinoma of esophagogastric junction; operation; sterilized water for injection; recurrence; metastasis; progression-free survival
PACS:
R735
DOI:
10.3969/j.issn.1672-4992.2021.04.013
Abstract:
Objective：To evaluate the effect of the amount of sterile water for injection for celiac irrigation in laparoscopic treatment of local advanced adenocarcinoma of esophagogastric junction (AEG).Methods:120 patients with advanced AEG who had celiac irrigation underwent laparoscopic surgery from October 2013 to December 2014 were selected and divided into 4 groups according to the amount of sterile water for injection,with 30 patients in each group,including group A with 1 000 mL,group B with 3 000 mL,group C with 5 000 mL,group D with 10 000 mL.The incidence of surgical complications and adverse reactions,postoperative local recurrence rate,metastasis rate and progression-free survival rate of the 4 groups were compared.Results:There was no significant difference in the incidence of surgical complications and adverse reactions among the 4 groups (P＞0.05).There was no significant difference in liver metastasis rate and 1-year progression-free survival rate among the 4 groups(P＞0.05),while there was no significant difference in local recurrence rate,metastasis rate and progression-free survival rate between the A and B groups (P＞0.05),and there was also no significant difference in local recurrence rate,metastasis rate and progression-free survival rate between groups C and D (P＞0.05).However,the local recurrence rate and peritoneal metastasis rate in C and D groups were lower than those in A and B groups,and the 3-year and 5-year progression-free survival rates were higher than those in A and B groups (P＜0.05).According to the depth of tumor invasion and stratification of lymph node metastasis,there was no significant difference in local recurrence rate,metastasis rate and progression-free survival rate amang 4 groups in T2 stage and those without lymph node metastasis (P＞0.05).There was no significant difference in liver metastasis rate and 1-year progression-free survival amang 4 groups in T3 or T4a stage and those with lymph node metastasis (P＞0.05).In the deeper tumor invasion with T3 or T4a stage,and in patients with lymph node metastasis,but local recurrence rate and celiac metastasis rate in C and D groups were lower than group A and B(P＜0.05),3-year and 5-year progression-free survival rates were higher than in A and B group (P＜0.05),and also peritoneal metastasis rate of group D was lower than that of group C (P＜0.05),3-year and 5-year progression-free survival rates were higher than that of group C (P＜0.05).Conclusion:We can effectively reduce local recurrence rate and celiac metastasis rate,improve progression-free survival,associated with the increase of the amount of sterile water for injection for celiac irrigation in laparoscopic treatment of patients with local advanced AEG.But it was useless to reduce liver metastasis rate.We should especially advocate using large amount of sterile water for injection to irrigate abdominal cavity during laparoscopic operation on AEG patients with deeper tumor invasion and lymph node metastasis.

References:

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陕西省自然科学基础研究计划（编号：2014JQ4123）
Last Update: 1900-01-01