|Table of Contents|

Identifcation of miRNA,lncRNA and mRNA-associated ceRNA networks and potential biomarker for oral squamous cell carcinoma with betel quid chewing in Hainan

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 04
Page:
573-579
Research Field:
Publishing date:

Info

Title:
Identifcation of miRNA,lncRNA and mRNA-associated ceRNA networks and potential biomarker for oral squamous cell carcinoma with betel quid chewing in Hainan
Author(s):
ZHU Qiao1; SHAO Xiaojun2; NING Chaoxue1; ZHAO Yali1
1.Central Laboratory；2.Stomatology Department,Hainan Hospital of PLA General Hospital,Hainan Sanya 572000,China.
Keywords:
betel quid; OSCC; ceRNA; Hainan
PACS:
R739.8
DOI:
10.3969/j.issn.1672-4992.2021.04.007
Abstract:
Objective：To construct the ceRNA network of oral squamous cell carcinoma (OSCC) induced by betel quid (BQ),and to explore the changes of regulatory pathways that may be affected by abnormal expression ceRNA.Methods:OSCC patients with BQ chewing were involved in this study and participants acted as their own control.MicroRNA sequencing and lncRNA microarray analysis were done.Subsequently,we established the ceRNA network.Results:ceRNA network was conducted in OSCC with BQ chewing.The lncRNA-miRNA-mRNA network was formed by 308 lncRNAs,41 miRNAs and 115 mRNAs.Conclusion:GO and KEGG analysis showed that the network involved in different signal pathways,such as the MAPK,apoptosis,p53 and PI3K/Akt signaling pathway.

References:

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三亚市医疗卫生科技创新项目（编号：2017YW23）
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