[1]RIZVI S，KHAN SA，HALLEMEIER CL，et al.Cholangiocarcinoma-evolving concepts and therapeutic strategies［J］.Nat Rev Clin Oncol，2018，15(2)：95-111.
[2]PATEL N，BENIPAL B.Incidence of cholangiocarcinoma in the USA from 2001 to 2015：A US cancer statistics analysis of 50 states［J］.Cureus，2019，11(1)：e3962.
[3]DE JONG MC，MARQUES H，CLARY BM，et al.The impact of portal vein resection on outcomes for hilar cholangiocarcinoma：A multi-institutional analysis of 305 cases［J］.Cancer，2012，18(19)：4737-4747.
[4]GROOT KOERKAMP B，WIGGERS JK，ALLEN PJ，et al.Recurrence rate and pattern of perihilar cholangiocarcinoma after curative intent resection［J］.J Am Coll Surg，2015，221(6)：1041-1049.
[5]VALLE J，WASAN H，PALMER DH，et al.Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer［J］.N Engl J Med，2010，362(14)：1273-1281.
[6]LIEBIG C，AYALA G，WILKS JA，et al.Perineural invasion in cancer：A review of the literature［J］.Cancer，2009，115(15)：3379-3391.
[7]CHEN SH，ZHANG BY，ZHOU B，et al.Perineural invasion of cancer：A complex crosstalk between cells and molecules in the perineural niche［J］.Am J Cancer Res，2019，9(1)：1-21.
[8]MORAN SP，MAKSYMETZ J，CONN PJ.Targeting muscarinic acetylcholine receptors for the treatment of psychiatric and neurological disorders［J］.Trends Pharmacol Sci，2019，40(12)：1006-1020.
[9]FENG YJ，ZHANG BY，YAO RY，et al.Muscarinic acetylcholine receptor M3 in proliferation and perineural invasion of cholangiocarcinoma cells［J］.Hepatobiliary Pancreat Dis Int，2012，11(4)：418-423.
[10]FENG Y，HU X，LIU G，et al.M3 muscarinic acetylcholine receptors regulate epithelial-mesenchymal transition，perineural invasion，and migration/metastasis in cholangiocarcinoma through the AKT pathway［J］.Cancer Cell Int，2018，18：173.
[11]SOMARELLI JA，SHETLER S，JOLLY MK，et al.Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of microRNA 200s and GRHL2［J］.Mol Cell Biol，2016，36(19)：2503-2513.
[12]PUISIEUX A，BRABLETZ T，CARAMEL J.Oncogenic roles of EMT-inducing transcription factors［J］.Nat Cell Biol，2014，16(6)：488-494.
[13]YANG X，JING D，LIU L，et al.Downregulation of p53 promotes in vitro perineural invasive activity of human salivary adenoid cystic carcinoma cells through epithelial-mesenchymal transition-like changes［J］.Oncol Rep，2015，33(4)：1650-1656.
[14]TEICHER BA，FRICKER SP.CXCL12(SDF-1)/CXCR4 pathway in cancer［J］.Clin Cancer Res，2010，16(11)：2927-2931.
[15]TAN XY，CHANG S，LIU W，et al.Silencing of CXCR4 inhibits tumor cell proliferation and neural invasion in human hilar cholangiocarcinoma［J］.Gut Liver，2014，8(2)：196-204.
[16]PYTLIAK M，VARGOVV，MECHROV V.Matrix metalloproteinases and their role in oncogenesis：A review［J］.Onkologie，2012，35(1-2)：49-53.
[17]CHINNI SR，SIVALOGAN S，DONG Z，et al.CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells：The role of bone microenvironment-associated CXCL12［J］.Prostate，2006，66(1)：32-48.
[18]JIANG YM，LI G，SUN BC，et al.Study on the relationship between CXCR4 expression and perineural invasion in pancreatic cancer［J］.Asian Pac J Cancer Prev，2014，15(12)：4893-4896.
[19]ALOE L，ROCCO ML，BALZAMINO BO，et al.Nerve growth factor：Role in growth，differentiation and controlling cancer cell development［J］.J Exp Clin Cancer Res，2016，35(1)：116.
[20]XU LB，LIU C，GAO GQ，et al.Nerve growth factor-beta expression is associated with lymph node metastasis and nerve infiltration in human hilar cholangiocarcinoma［J］.World J Surg，2010，34(5)：1039-1045.
[21]YUE XJ，XU LB，ZHU MS，et al.Over-expression of nerve growth factor-b in human cholangiocarcinoma QBC939 cells promote tumor progression［J］.PloS One，2013，8(4)：e0062024.
[22]RAMREZ-MERINO N，AIX SP，CORTS-FUNES H.Chemotherapy for cholangiocarcinoma：An update［J］.World J Gastrointest Oncol，2013，5(7)：171-176.
[23]BAPAT AA，MUNOZ RM，VON HOFF DD，et al.Blocking nerve growth factor signaling reduces the neural invasion potential of pancreatic cancer cells［J］.PLoS One，2016，11(10)：e0165586.
[24]MA J，JIANG Y，JIANG Y，et al.Expression of nerve growth factor and tyrosine kinase receptor A and correlation with perineural invasion in pancreatic cancer［J］.J Gastroenterol Hepatol，2008，23(12)：1852-1859.
[25]LIN S，GREGORY RI.MicroRNA biogenesis pathways in cancer［J］.Nat Rev Cancer，2015，15(6)：321-333.
[26]BARBATO S，SOLAINI G，FABBRI M.Micrornas in oncogenesis and tumor suppression［J］.Int Rev Cell Mol Biol，2017，333：229-268.
[27]LETELIER P，RIQUELME I，HERNNDEZ AH，et al.Circulating microRNAs as biomarkers in biliary tract cancers［J］.Int J Mol Sci，2016，17(5)：E791.
[28]XIONG B，CHENG Y，MA L，et al.MiR-21 regulates biological behavior through the PTEN/PI-3K/Akt signaling pathway in human colorectal cancer cells［J］.Int J Oncol，2013，42(1)：219-228.
[29]LIU ZL，WANG H，LIU J，et al.MicroRNA-21(miR-21) expression promotes growth，metastasis，and chemo-or radioresistance in non-small cell lung cancer cells by targeting PTEN［J］.Mol Cell Biochem，2013，372(1-2)：35-45.
[30]HAO Y，ZHAO Y，ZHAO X，et al.Improvement of prostate cancer detection by integrating the PSA test with miRNA expression profiling［J］.Cancer Invest，2011，29(4)：318-324.
[31]CHUSORM P，NAMWAT N，LOILOME W.Overexpression of microRNA-21 regulating PDCD4 during tumorigenesis of liver fluke-associated cholangiocarcinoma contributes to tumor growth and metastasis［J］.Tumour Biol，2013，34(3)：1579-1588.
[32]HUANG Q，LIU L，LIU CH，et al.MicroRNA-21 regulates the invasion and metastasis in cholangiocarcinoma and may be a potential biomarker for cancer prognosis［J］.Asian Pac J Cancer Prev，2013，14(2)：829-834.
[33]XIAO T，JIE ZG.MiR-21 promotes the invasion and metastasis of gastric cancer cells by activating epithelial-mesenchymal transition［J］.Eur Surg Res，2019，60：208-218.
[34]DE CRAENE B，BERX G.Regulatory networks defining EMT during cancer initiation and progression［J］.Nat Rev Cancer，2013，13(2)：97-110.
[35]LI Q，XIA X，JI J，et al.MiR-199a-3p enhances cisplatin sensitivity of cholangiocarcinoma cells by inhibiting mTOR signaling pathway and expression of MDR1［J］.Oncotarget，2017，8(20)：33621-33630.
[36]IYER MK，NIKNAFS YS，MALIK R，et al.The landscape of long noncoding RNAs in the human transcriptome［J］.Nat Genet，2015，47(3)：199-208.
[37]WANG C，MAO ZP，WANG L，et al.Long non-coding RNA MALAT1 promotes cholangiocarcinoma cell proliferation and invasion by activating PI3K/Akt pathway［J］.Neoplasma，2017，64(5)：725-731.
[38]TAN X，HUANG Z，LI X.Long non-coding RNA MALAT1 interacts with mir-204 to modulate human hilar cholangiocarcinoma proliferation，migration，and invasion by targeting CXCR4［J］.J Cell Biochem，2017，118(11)：3643-3653.
[39]SHI X，ZHANG H，WANG M，et al.LncRNA AFAP1-AS1 promotes growth and metastasis of cholangiocarcinoma cells［J］.Oncotarget，2017，8(35)：58394-58404.
[40]WANG WT，YE H，WEI PP，et al.LncRNAs H19 and HULC，activated by oxidative stress，promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner［J］.J Hematol Oncol，2016，9(1)：117.
[41]KIM HJ，EOH KJ，KIM LK，et al.The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer［J］.Oncotarget，2016，7(50)：83001-83016.
[42]GU Y，LI C，XIAO L，et al.High expression of long non-coding RNA NNT-AS1 facilitates progression of cholangiocarcinoma through promoting epithelial-mesenchymal transition［J］.Am J Transl Res，2019，11(9)：5438-5456.
[43]XU Y，YAO Y，QIN W，et al.Long non-coding RNA CCAT2 promotes cholangiocarcinoma cells migration and invasion by induction of epithelial-to-mesenchymal transition［J］.Biomed Pharmacother，2018，99：121-127.
[44]XU Y，YAO Y，LENG K，et al.Long non-coding RNA UCA1 indicates an unfavorable prognosis and promotes tumorigenesis via regulating AKT/GSK-3β signaling pathway in cholangiocarcinoma［J］.Oncotarget，2017，8(56)：96203-96214.
[45]ZHANG C，LI JY，TIAN FZ，et al.Long noncoding RNA NEAT1 promotes growth and metastasis of cholangiocarcinoma cells［J］.Oncol Res，2018，26(6)：879-888.
[46]SHI J，LI X，ZHANG F，et al.The plasma LncRNA acting as fingerprint in hilar cholangiocarcinoma［J］.Cell Physiol Biochem，2018，49(5)：1694-1702.
[47]FENG J，HU H，YUAN C，et al.Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth，migration and invasion in pancreatic cancer［J］.Oncol Rep，2014，32(6)：2485-2492.