|Table of Contents|

Review of human papillomavirus negative cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 02
Page:
345-348
Research Field:
Publishing date:

Info

Title:
Review of human papillomavirus negative cervical cancer
Author(s):
YANG Pan12ZHANG Mengzhen1
1.The First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052,China;2.Huanghe Sanmenxia Hospital,Henan Sanmenxia 472000,China.
Keywords:
human papillomaviruscervical cancerhuman papillomavirus negative
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2021.02.036
Abstract:
Cervical cancer is the most common malignant tumor in gynecology.Studies have confirmed that 99.7% of cervical cancer is caused by human papillomavirus (HPV),but almost all studies have found the presence of HPV negative cervical cancer.HPV test negative cervical cancer can be summarized as false negative and true negative conditions.The causes of false negative include smaller disease,limited resources,low viral load,non-high-risk HPV genotype,technical errors or insufficient detection sensitivity.Existing screening methods have certain limitations,and some novel molecular markers with high sensitivity and specificity,such as microRNAs and methylation of FAM19A4 gene,have been proved to be promising for the early detection and diagnosis of cervical cancer.In recent years,there are more and more studies on HPV negative cervical cancer,but there are differences in the analysis of clinical characteristics of HPV negative cervical cancer patients.This article mainly reviews the causes,screening diagnosis and clinical characteristics of HPV false-negative cervical cancer.

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Memo:
河南省教育厅科研立项基金(编号:19A320007)
Last Update: 1900-01-01