|Table of Contents|

miR-155 in predicting prognosis of diffuse large B-cell lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 02
Page:
307-311
Research Field:
Publishing date:

Info

Title:
miR-155 in predicting prognosis of diffuse large B-cell lymphoma
Author(s):
LI Xing1; SHI Hao2
1.Department of Oncology and Hematology;2.Department of Otolaryngology,Head and Neck Surgery,Yan’an People’s Hospital,Shaanxi Yan’an 716000,China.
Keywords:
miR-155; diffuse large B-cell lymphoma; prognosis
PACS:
R733.4
DOI:
10.3969/j.issn.1672-4992.2021.02.027
Abstract:
Objective:To evaluate the value of miR-155 in predicting prognosis of diffuse large B-cell lymphoma.Methods:120 cases of diffuse large B-cell lymphoma in our hospital were selected as the subjects.The relative expression of miR-155 in all patients was detected by qRT-PCR.According to the expression level of miR-155,all patients were divided into two groups:high expression of miR-155 (n=72) and low expression of miR-155 (n=48).The clinicopathological data and survival rate of the two groups were compared.The Cox proportional hazard regression model was used to analyze diffuse large B patients.The prognosis of patients with cell lymphoma was analyzed by single factor and multi-factor,and the effect of miR-155 on the proliferation and migration of diffuse large B-cell lymphoma cells was analyzed.Results:The percentage of extranodal invasion in patients with high expression of miR-155 was significantly higher than that in patients with low expression of miR-155(P＜0.05),and the 3-year non-progression-free survival rate(29.2%) and the overall survival rate(40.3%) of the miR-155 high-expression group were significantly lower than that of the miR-155 lower-expression group(81.3% and 83.3%)(P＜0.05).The single-factor and multi-factor analysis results showed that the miR-155 expression level is the influencing factor of the progression-free survival and overall survival of the DLBCL.The healing rate of scratches in the low expression group of miR-155(0.53±0.04) was significantly lower than that in the control group(1.00±0.03)(P＜0.05).The absorbance of cells in the low expression group of miR-155 was significantly lower than that in the control group on the 3rd and 4th day after culture(0.38±0.01 vs 0.56±0.03,0.56±0.02 vs 0.76±0.02)(P＜0.05).Conclusion:The expression level of miR-155 in patients with diffuse large B-cell lymphoma significantly affects the prognosis of the patients,and the possible mechanism is that it can affect the prognosis of patients with diffuse large B-cell lymphoma.The ability of proliferation and migration of cell lymphoma suggests that miR-155 may be a new and reliable prognostic biomarker for diffuse large B-cell lymphoma,which deserves further study.

References:

［1］ 郭俊宇.C-myc Bcl-2表达在弥漫大B细胞淋巴瘤预后中的价值分析［J］.山西医药杂志,2017,46(9):1061-1063.GUO JY.Value analysis of c-myc bcl-2 expression in prognosis of diffuse large B-cell lymphoma ［J］.Shanxi Journal of Medicine,2017,46(9):1061-1063.
［2］ 李超,刘春艳,王玉.miR-31、miR-21和miR-155在弥漫大B细胞淋巴瘤中的表达及意义［J］.中国热带医学,2017,17(10):1021-1026.LI C,LIU CY,WANG Y.Expression and significance of miR-31,miR-21 and miR-155 in diffuse large B-cell lymphoma ［J］.Chinese Tropical Medicine,2017,17(10):1021-1026.
［3］ 姚晓香,王晋芬,王跃华,等.microRNA-223与弥漫性大B细胞淋巴瘤预后的相关性［J］.中华病理学杂志,2012,41(6):366-370.YAO XX,WANG JF,WANG YH,et al.Correlation between microrna-223 and prognosis of diffuse large B cell lymphoma ［J］.Chin J Pathology,2012,41(6):366-370.
［4］ 刘虹,李燕.miRNA-155在维吾尔族慢性淋巴细胞白血病患者中的表达及其临床意义［J］.肿瘤研究与临床,2017,29(11):731-735.LIU H,LI Y.Expression and clinical significance of miRNA-155 in uygur patients with chronic lymphocytic leukemia ［J］.Cancer Research and Clinical,2017,29(11):731-735.
［5］ BAI,HAITAO,WEI,et al.MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma;cells to the CHOP chemotherapy regimen［J］.Int J Hematol,2013,97(2):223-231.
［6］ 段卫明,姚利,陶敏,等.三阴性乳腺癌患者miR-155表达水平及其对预后的预测价值研究［J］.中国全科医学,2017,20(22):2763-2767.DUAN WM,YAO L,TAO M,et al.Study on miR-155 expression level and its prognostic value in patients with triple negative breast cancer ［J］.Chinese General Practice,2017,20(22):2763-2767.
［7］ RAI D,RAJEWSKY K.Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis［J］.Proc Natl Acad Sci USA,2010,107(7):3111-3116.
［8］ 戴斌,杨颖乔,黄翠萍.miR-133b与miR-155在非小细胞肺癌患者肿瘤及周围组织中的表达及意义［J］.基因组学与应用生物学,2017,36(5):1702-1708.DAI B,YANG YQ,HUANG CP.Expression and significance of miR-133b and miR-155 in tumors and surrounding tissues of patients with non-small cell lung cancer ［J］.Genomics and Applied Biology,2017，36(5):1702-1708.
［9］ HANA H,KATARINA K,JOSEF K,et al.Oncogenic microRNA-155 and its target PU.1:an integrative gene expression study in six of the most prevalent lymphomas［J］.International Journal of Hematology,2015,102(4):441-450.
［10］ 冯晓云,严玲玲.miR-21、miR-155、miR-210的临床表达意义及其与淋巴瘤病理特征的相关性分析［J］.中国医药导报,2017,23:84-87.FENG XY,YAN LL.Clinical expression significance of miR-21,miR-155 and miR-210 and their correlation with pathological characteristics of lymphoma ［J］.China Medical Herald,2017,23:84-87.
［11］ WU X,WANG F,LI Y,et al.Evaluation of latent membrane protein 1 and microRNA-155 for the prognostic prediction of diffuse large B cell lymphoma［J］.Oncology Letters,2018,15(6):9725-9734.
［12］ LV L,AN X,LI H,et al.Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells［J］.Oncology Letters,2015,11(2):1161-1166.
［13］ 孙冠星,曹祥山,李青,等.miR-155、miR-34a和miR-30a在弥漫大B细胞淋巴瘤中的表达及意义［J］.中华医学遗传学杂志,2013,30(1):79-83.SUN GX,CAO XS,LI Q,et al.Expression and significance of miR-155,miR-34a and miR-30a in diffuse large B-cell lymphoma ［J］.Chinese Journal of Medical Genetics,2013,30(1):79-83.
［14］ LIXIA LV,XIUMEI AN,HONGYAN LI,et al.Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells［J］.Oncology Letters,2015,11(2):1161-1166.
［15］ ZENG QI,TAO X,FANG H,et al.Overexpression of miR-155 promotes the proliferation and invasion of oral squamous carcinoma cells by regulating BCL6/cyclin D2［J］.International Journal of Molecular Medicine,2016,37(5):1274-1280.
［16］ SLEZAKPROCHAZKA I,KIUIVER J,JONG DD,et al.Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma［J］.Oncotarget,2016,7(3):2391-2400.

Memo

Memo:
-
Last Update: 1900-01-01