|Table of Contents|

Detection of CTCs and CEA mRNA levels in tumor venous blood of patients with colorectal cancer for predicting metachronous liver metastasis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 02
Page:
263-266
Research Field:
Publishing date:

Info

Title:
Detection of CTCs and CEA mRNA levels in tumor venous blood of patients with colorectal cancer for predicting metachronous liver metastasis
Author(s):
CHENG Huangrong; ZHENG Yongbin
Department of Gastrointestinal Surgery Division 1,Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China.
Keywords:
colorectal cancer; metachronous liver metastasis; CTCs; CEA mRNA
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2021.02.017
Abstract:
Objective:To investigate the predictive value of separate detection of tumor venous blood circulation tumor cells (CTCs),carcinoembryonic antigen messenger ribonucleic acid (CEA mRNA) and combined detection in colorectal cancer patients for metachronous liver metastasis.Methods:The CTCs and CEA mRNA were detected in the tumor venous blood of 75 patients without liver metastasis and the correlation indexes of CTCs and CEA mRNA with metachronous liver metastasis and TNM staging were analyzed after half year follow-up.Results:The sensitivity of separate detection of CTCs,CEA mRNA andcombined detection to predict metachronous liver metastasis was 86.7%(13/15),73.3%(11/15)and 90.9%(10/11),respectively,and the specificity was 90.0%(54/60), 83.3%(50/60)and 92.2%(59/64),respectively.CTCs,CEA mRNA levels are closely related to TNM staging(P＜0.05).Conclusion:Metachronous liver metastasis is associated with tumor size,depth of tumor invasion,degree of tumor differentiation,lymph node metastasis and TNM staging.CTCs and CEA mRNA could be used as early predictors of metachronous liver metastasis from colorectal cancer.Combined detection of CTCs and CEA mRNA is more effective than separate.

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