|Table of Contents|

Effect of lobectomy and wedge resection on prognosis of elderly patients with stage I b NSCLC

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 02
Page:
253-257
Research Field:
Publishing date:

Info

Title:
Effect of lobectomy and wedge resection on prognosis of elderly patients with stage I b NSCLC
Author(s):
LIU Jidong; YANG Yan; LIU Ying
Department of Respiratory Medicine,Panzhihua Central Hospital,Sichuan Panzhihua 617067,China.
Keywords:
non-small cell lung cancer; lobectomy; wedge resection; overall survival rate
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2021.02.015
Abstract:
Objective:To investigate the effect of lobectomy and wedge resection on the prognosis of elderly patients with stage I b NSCLC.Methods:A total of 130 patients with NSCLC were selected and divided into lobectomy group and wedge resection group.The difference between the two groups was compared.Results:Compared with the cuneate resection group,the operation time,the drainage time of the thoracic duct were significantly longer and the blood loss was more (P＜0.05),but there was no significant difference in the incidence of complications,type of complications and the time of hospitalization in the two groups (P＞0.05).The total survival rate of the lobectomy group and the lung wedge resection group was 76.9% and 82.1% respectively,and the recurrence rates were 32.9% and 38.5% respectively,and the difference was not statistically significant (P＞0.05).Pathological classification,pathological type,T staging and pleural invasion were independent risk factors (P＜0.05).The type of non adenocarcinoma,pleural invasion,the lower the pathological grade,the higher the T staging were corrected with the lower the 5 years survival rate of the patients.Pathological grade,pathological type and T staging were independent risk factors that affect the 5 years survival rate of the patients (P＜0.05).The lower the type of adenocarcinoma,the lower the pathological grade,the higher the T staging,the higher the recurrence rate of the patients.Conclusion:For the elderly NSCLC patients with stage Ⅰb,the cuneate resection of lung can obtain the similar long-term survival rate and relapse control rate on the basis of retaining more lung tissues and lobectomy,which is worthy of clinical promotion.

References:

［1］ 杨俊波,黄晓洁,黄春蓉,等.2003年-2013年某三甲综合医院肿瘤住院患者病死率及死因分析［J］.现代肿瘤医学,2016,24(10):1642-1645. YANG JB,HUANG XJ,HUANG CR,et al.Mortality rate and cause of death of cancer inpatients in a third-class general hospital from 2003 to 2013 ［J］.Modern Oncology,2016,24(10):1642-1645.
［2］ YAN C,SHI X,ZHENG J,et al.MiR-760 suppresses non-small cell lung cancer proliferation and metastasis by targeting ROS1［J］.Environmental Science & Pollution Research International,2018,25(19):18385-18391.
［3］ CHANG JY,JABBOUR SK,RUYSSCHER DD,et al.Consensus statement of proton therapy in early stage and locally advanced non-small cell lung cancer［J］.International Journal of Radiation Oncology Biology Physics,2016,95(1):505-516.
［4］ DENG HY,WANG YC,NI PZ,et al.Radiotherapy,lobectomy or sublobar resection? A meta-analysis of the choices for treating stage I non-small-cell lung cancer［J］.Eur J Cardiothorac Surg,2017,51(2):203-210.
［5］ STILES BM,KAMEL MK,NASAR A,et al.The importance of lymph node dissection accompanying wedge resection for clinical stage Ia lung cancer［J］.Eur J Cardiothorac Surg,2017,51(3):511-517.
［6］ 张长海.老年肺癌与中青年肺癌的临床特点分析［J］.现代肿瘤医学,2015,23(14):1983-1985. ZHANG CH.Clinical characteristics of lung cancer in the elderly and middle-aged and young people［J］.Modern Oncology,2015,23(14):1983-1985.
［7］ LIM CG,SHIN KM,LIM JS,et al.Predictors of conversion to thoracotomy during video-assisted thoracoscopic surgery lobectomy in lung cancer:additional predictive value of FDG-PET/CT in a tuberculosis endemic region［J］.J Thorac Dis,2017,9(8):2427-2436.
［8］ MAFé JJ,PLANELLES B,ASENSIO S,et al.Cost and effectiveness of lung lobectomy by video-assisted thoracic surgery for lung cancer［J］.J Thorac Dis,2017,9(8):2534-2543.
［9］ SAWABATA N,KAWASE A,TAKAHASHI N,et al.Validating margin status in lung wedge resection for clinical stage I non-small cell lung cancer［J］.Surgery Today,2018,48(3):1-5.
［10］ MCGUIRE AL,HOPMAN WM,PETSIKAS D,et al.Outcomes:Wedge resection versus lobectomy for non-small cell lung cancer at the Cancer Centre of Southeastern Ontario 1998-2009［J］.Canadian Journal of Surgery Journal Canadien De Chirurgie,2013,56(6):E165-E170.
［11］ TSUNEZUKA H,KATO D,OKADA S,et al.Surgical outcome of wide wedge resection in poor-risk patients with clinical-N0 non-small cell lung cancer［J］.General Thoracic & Cardiovascular Surgery,2017,65(10):1-6.
［12］ 史学良,罗杰,方秦模,等.胸腔镜亚肺叶切除术治疗肺部疾病的临床分析［J］.中国老年学,2015,35(13):3675-3676. SHI XL,LUO J,FANG QM,et al.Clinical analysis of thoracoscopic subpulmonary lobectomy for lung diseases ［J］.Gerontology of China,2015,35(13):3675-3676.
［13］ WANG Y,WANG R,ZHENG D,et al.Predicting the recurrence risk factors and clinical outcomes of peripheral pulmonary adenocarcinoma≤3 cm with wedge resection［J］.Journal of Cancer Research & Clinical Oncology,2017,143(6):1-9.
［14］ MERY CM,PAPPAS AN,BUENO R,et al.Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance,epidemiology,and end results database［J］.Chest,2005,128(1):237-245.
［15］ TSUTANI Y,MIYATA Y,NAKAYAMA H,et al.Oncologic outcomes of segmentectomy compared with lobectomy for clinical stage Ia lung adenocarcinoma:propensity score-matched analysis in a multicenter study［J］.Journal of Thoracic & Cardiovascular Surgery,2013,146(2):358-364.
［16］ LANDRENEAU RJ,NORMOLLE DP,CHRISTIE NA,et al.Recurrence and survival outcomes after anatomic segmentectomy versus lobectomy for clinical stage I non-small-cell lung cancer:A propensity-matched analysis［J］.J Clin Oncol,2014,32(23):2449-2455.
［17］ ZHANG Y,SUN Y,WANG R,et al.Meta-analysis of lobectomy,segmentectomy,and wedge resection for stage I non-small cell lung cancer［J］.J Surg Oncol,2015,111(3):334-340.

Memo

Memo:
-
Last Update: 1900-01-01