|Table of Contents|

Expression and clinical significance of thioredoxin 1 and haptoglobin in serum of patients with non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 02
Page:
238-242
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of thioredoxin 1 and haptoglobin in serum of patients with non-small cell lung cancer
Author(s):
YU Jihui; ZHAO Wenping; CHEN Rong; LUO Yue; SUN Yanli
Health Management Center,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China.
Keywords:
thioredoxin 1; haptoglobin; non-small cell lung cancer
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2021.02.012
Abstract:
Objective:To investigate the expression and clinical significance of serum thioredoxin 1 (Trx1) and haptoglobin (Hp) in non-small cell lung cancer (NSCLC).Methods：From January 2016 to December 2018,186 patients with non-small cell lung cancer treated in the department of our hospital (experimental group) were selected,and 80 patients (control group) with health checkups in our hospital were selected.Serum Trx1 and Hp levels in two groups were detected.Serum Trx1 and Hp differences in different clinicopathological characteristics were analysed.The diagnostic efficacy of serum Trx1 and Hp in predicting the occurrence of non-small cell lung cancer was analyzed.Results：The levels of serum Trx1 and Hp in the experimental group were higher than those in the control group,and the difference was statistically significant (P＜0.05).There were significant differences in Trx1 and Hp level between NSCLC patients with a tumor diameter of ≥3 cm,poor differentiation,TNM stage (stageⅢ+IV),and lymph node metastasis and NSCLC patients with tumor diameter of <3 cm,moderate and well differentiation,TNM stage (stageⅠ+Ⅱ),and no lymph node metastasis (P＜0.05).The results of the ROC curve showed that the area under the curve for the combined detection of Trx1 and Hp was 0.840,and the sensitivity and specificity were 0.882 and 0.827,respectively.Kaplan-Meier analysis showed that the survival rate of patients with low-level serum Trx1 and Hp was higher than that with high-level patients (P＜0.05).Conclusion：Serum Trx1 and Hp expression levels are elevated in NSCLC.Changes in serum Trx1 and Hp levels are related to the progression of NSCLC.Combined detection of serum Trx1 and Hp is of great significance in predicting the occurrence and prognosis of NSCLC.

References:

［1］陈万青，郑荣寿，张思维，等.2012年中国恶性肿瘤发病和死亡分析［J］.中国肿瘤，2017，24（1）：1-7. CHEN WQ,ZHENG RS,ZHANG SW,et al.Analysis of the incidence and death of malignant tumors in China in 2012 ［J］.China Cancer,2017,24(1):1-7.
［2］JP FAN,HY YU,Y LV,et al.Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients［J］.Tumour Biol,2016,37(2):1949-1958.
［3］ HAMAGUCHI R,OKAMOTO T,SATO M,et al.Effects of an alkaline diet on EGFR-TKI therapy in EGFR mutation-positive NSCLC ［J］.Anticaneer Res,2017,37(9):5141-5145.
［4］BALSEM M,BUCHANAN BB.Evolution of the thioredoxin system as a step enabling ad8ptation to oxidative stress［J］.Free Radic Biol Med,2019,140（8）:28-35.
［5］惠凌云，申秋菊，王婷，等.TRX1与JAB1 在急性髓系白血病中的表达及其相关性［J］.西安交通大学学报（医学版），2017，38（1）：62-66. HUI LY,SHEN QJ,WANG T,et al.Expression and correlation of TRX1 and JAB1 in acute myeloid leukemia ［J］.Journal of Xi'an Jiaotong University (Medical Edition),2017,38(1):62-66.
［6］SHANG W,XIE Z,LU F,et al.Increased thioredoxin-1 expression promotes cancer progression and predicts poor prognosis in patients with gastric cancer［J］.Oxid Med Cell Longev,2019,2019(2):9291683.
［7］叶健波.甲状腺乳头状癌女性患者血清25-羟维生素D和触珠蛋白的水平及其临床意义［J］.实用癌症杂志，2016，31（6）：901-904. YE JB.Serum 25-hydroxyvitamin D and haptoglobin levels in female patients with papillary thyroid carcinoma and their clinical significance ［J］.Journal of Practical Cancer,2016,31(6):901-904.
［8］HORIMASU Y,ISHIKAWA N,TANAKA S,et al.MUC1 in lung adenocarcinoma:Cross-sectional genetic and serological study［J］.BMC Cancer,2017,17(1):263.
［9］彭俊琴，汤日杰，张海南，等.非高场MR扩散加权成像在小细胞肺癌及非小细胞肺癌鉴别诊断中的应用与 b值优化［J］.实用医学杂志，2015，31（6）：969-972. PENG JQ,TANG RJ,ZHANG HN,et al.Application of non-high field MR diffusion weighted imaging in the differential diagnosis of small cell lung cancer and non-small cell lung cancer and optimization of b-value ［J］.Journal of Practical Medicine,2015,31（6）:969-972.
［10］HAWKES HJK,KARLENIUS TC,TONISSEN KF.Regulation of the human thioredoxin gene promoter and its key substrates:A study of functional and putative regulatory elements［J］.Biochimica et Biophysica Acta (BBA) - General Subjects,2014,1840(1):303-314.
［11］ZHU H,TAO X,ZHOU L,et al.Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT［J］.BMC Cancer,2019,19(1):865.
［12］CARVALHO LML,FERREIRA CN,DE OLIVEIRA DKD,et al.Haptoglobin levels,but not Hp1-Hp2 polymorphism,are associated with polycystic ovary syndrome［J］.J Assist Reprod Genet,2017,34(12):1691-1698.
［13］ZHANG S,SHANG S,LI W,et al.Insights on N-glycosylation of human haptoglobin and its association with cancers［J］.Glycobiology,2016,26(7):684-692.
［14］郑晓，吴叶晨，高道键，等.触珠蛋白作为胆道肿瘤胆汁和血清生物标志物的研究［J］.中华消化内镜杂志，2018，35（3）：171-174. ZHENG X,WU YC,GAO DJ,et al.Study on haptoglobin as a bile and serum biomarker for biliary tract tumors ［J］.Chinese Journal of Digestive Endoscopy,2018,35(3):171-174.
［15］LU J,WANG Y,YAN M,et al.High serum haptoglobin level is associated with tumor progression and predicts poor prognosis in non-small cell lung cancer［J］.Oncotarget,2016,7(27):41758-41766.
［16］CHANG YK,LAI YH,CHU Y,et al.Haptoglobin is a serological biomarker for adenocarcinoma lung cancer by using the ProteomeLab PF2D combined with mass spectrometry［J］.Am J Cancer Res,2016,6(8):1828-1836.

Memo

Memo:
重庆市卫生计生委医学科研面上项目（编号：20142019）
Last Update: 1900-01-01