|Table of Contents|

Expression of GRK5 and Ki-67 in glioma tissues and analysis of its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 02
Page:
215-219
Research Field:
Publishing date:

Info

Title:
Expression of GRK5 and Ki-67 in glioma tissues and analysis of its clinical significance
Author(s):
ZHANG Hui; FAN Yuechao; CHEN Hongfu; JI Peizhi; MIAO Faan; CHEN Chen
Department of Cranial Base Tumor Surgery,Affiliated Hospital of Xuzhou Medical University,Jiangsu Xuzhou 221002,China.
Keywords:
glioma; GRK5; Ki-67; correlation
PACS:
R739.4
DOI:
10.3969/j.issn.1672-4992.2021.02.008
Abstract:
Objective:To investigate the expression of GRK5 and Ki-67 in glioma tissues,the relationship between the expression of GRK5 and Ki-67 in gliomas,and the prognostic value of GRK5 and Ki-67 in gliomas.Methods:This study collected tissue samples from 104 glioma patients who were surgically resected from January 2014 to January 2017 in our hospital and 20 normal brain tissues that were surgically resected by intracranial decompression due to intracranial injury during the same period.Immunohistochemical SP method was used to detect the expression levels of GRK5 and Ki-67 in glioma tissue and normal brain tissue.Spearman rank correlation analysis was used for correlation analysis.The chi-square test was used to analyze the correlation between the expression of GRK5 and Ki-67 in glioma tissues and the clinicopathological characteristics.Kaplan-Meier and Log-rank tests were used for survival analysis,and Cox proportional risk model was used for prognostic analysis.Results:The results of immunohistochemical detection showed that 66 cases of GRK5 were positively expressed in 104 glioma tissues,with a positive rate of 63.5%.2 cases were positively expressed in 20 normal brain tissues,with a positive rate of 10.0%.Ki-67 was positively expressed in 104 glioma tissues in 69 cases,with a positive rate of 66.3%.The positive expression rate was 0.0% in 20 normal brain tissues.Spearman rank correlation analysis showed that GRK5 and Ki-67 expressions were positively correlated in glioma tissues (r=0.558,P=0.000).The relationship between the expression of GRK5 and Ki-67 and the clinicopathological characteristics of glioma patients was analyzed.The results showed that the expression of GRK5 and Ki-67 was related to WHO grading (P＜0.05),but not to gender,age,tumor diameter and tumor type (P＞0.05).Survival analysis of 104 patients showed that the survival rate of GRK5 positive expression was significantly lower than the negative expression (P=0.033).The survival rate of Ki-67 positive expression was significantly lower than the negative expression (P=0.033).Cox regression model analysis showed that both GRK5 positive expression and Ki-67 positive expression were independent risk factors affecting the prognosis of glioma patients (P＜0.05).Conclusion:GRK5 and Ki-67 are related to the occurrence,development and proliferation of gliomas.GRK5 and Ki-67 may be used as prognostic markers and indicators of clinical detection or combined detection in glioma patients to improve the clinical diagnosis rate.

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Memo

Memo:
江苏省卫生健康科研基金资助（编号：WJ2018G121）
Last Update: 1900-01-01