|Table of Contents|

Research advances of radiation-induced heart disease

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
159-162
Research Field:
Publishing date:

Info

Title:
Research advances of radiation-induced heart disease
Author(s):
FENG Zongjian; E Mingyan
Department of Chest Radiotherapy，Cancer Hospital Affiliated to Harbin Medical University，Heilongjiang Harbin 150081，China.
Keywords:
thoracic radiotherapy; radiotherapy-induced heart disease; serum biomarker
PACS:
R730.6
DOI:
10.3969/j.issn.1672-4992.2021.01.036
Abstract:
As a key component of local treatment for patients with chest malignant tumors，radiation therapy can effectively improve the local control rate and patients' long-term survival.However，in the process of radiotherapy，due to the anatomic factor，the heart as a vital organ at risk is irradiated inevitably.Radiation-related heart disease had become one of the main non-tumor death causes for patients who received thoracic radiotherapy.Radiation-induced heart disease (RIHD) has received more widespread attention in clinic and basic research.A great number of studies have been carried out to explore the pathogenesis and serum biomarkers，in order to interfere with RIHD as early as possible and then improve patients' quality of life and survival.This article reviewed the development of RIHD.

References:

［1］FRANDSEN J，BOOTHE D，GAFFNEY DK，et al.Increased risk of death due to heart disease after radiotherapy for esophageal cancer［J］.J Gastrointest Oncol，2015，6(5)：516-523.
［2］XU D，LI G，LI H，et al.Comparison of IMRT versus 3D-CRT in the treatment of esophagus cancer：A systematic review and meta-analysis［J］.Medicine(Baltimore)，2017，96(31)：e7685.
［3］ARAS S，IKIZCELI T，AKTAN M.Dosimetric comparison of three-dimensional conformal radiotherapy(3D-CRT) and intensity modulated radiotherapy techniques(IMRT) with radiotherapy dose simulations for left-sided mastectomy patients［J］.Eur J Breast Health，2019，15(2)：85-89.
［4］GKANTAIFI A，PAPADOPOULOS C，SPYROPOULOU D，et al.Breast radiotherapy and early adverse cardiac effects:the role of serum biomarkers and strain echocardiography［J］.Anticancer Res，2019，39(4)：1667-1673.
［5］STEWART FA，HOVING S，RUSSELL NS.Vascular damage as an underlying mechanism of cardiac and cerebral toxicity in irradiated cancer patients［J］.Radiat Res，2010，174(6)：865-869.
［6］TAUNK NK，HAFFTY BG，KOSTIS JB，et al.Radiation-induced heart disease：Pathologic abnormalities and putative mechanisms［J］.Front Oncol，2015，5：39.
［7］AHAMED J，LAURENCE J.Role of platelet-derived transforming growth factor-β1 and reactive oxygen species in radiation-induced organ fibrosis［J］.Antioxid Redox Signal，2017，27(13)：977-988.
［8］YARNOLD J，BROTONS MC.Pathogenetic mechanisms in radiation fibrosis［J］.Radiother Oncol，2010，97(1)：149-161.
［9］FARHOOD B，ALIASGHARZADEH A，AMINI P，et al.Radiation-induced dual oxidase upregulation in rat heart tissues：Protective effect of melatonin［J］.Medicina(Kaunas)，2019，55(7)：e317.
［10］SEDDON M，LOOI YH，SHAH AM.Oxidative stress and redox signalling in cardiac hypertrophy and heart failure［J］.Heart，2007，93(8)：903-907.
［11］FINET JE.Management of heart failure in cancer patients and cancer survivors［J］.Heart Fail Clin，2017，13(2)：253-288.
［12］KURA B，BABAL P，SLEZAK J.Implication of microRNAs in the development and potential treatment of radiation-induced heart disease［J］.Can J Physiol Pharmacol，2017，95(10)：1236-1244.
［13］JIANG LP，HE CY，ZHU ZT.Role of microRNA-21 in radiosensitivity in non-small cell lung cancer cells by targeting PDCD4 gene［J］.Oncotarget，2017，8(14)：23675-23689.
［14］KURA B，YIN C，FRIMMEL K，et al.Changes of microRNA-1，-15b and -21 levels in irradiated rat hearts after treatment with potentially radioprotective drugs［J］.Physiol Res，2016，65(Suppl 1)：S129-137.
［15］VICZENCZOVA C，KURA B，EGAN BENOVA T，et al.Irradiation-induced cardiac connexin-43 and miR-21 responses are hampered by treatment with atorvastatin and aspirin［J］.Int J Mol Sci，2018，19(4)：e1128.
［16］KURA B，KALOCAYOVA B，LEBARON TW，et al.Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium［J］.Mol Cell Biochem，2019，457(1/2)：61-72.
［17］HAWKINS PG，SUN Y，DESS RT，et al.Circulating microRNAs as biomarkers of radiation-induced cardiac toxicity in non-small-cell lung cancer［J］.J Cancer Res Clin Oncol，2019，145(6)：1635-1643.
［18］WYNN TA，RAMALINGAM TR.Mechanisms of fibrosis：therapeutic translation for fibrotic disease［J］.Nat Med，2012，18(7)：1028-1040.
［19］MONCEAU V，MEZIANI L，STRUP-PERROT C，et al.Enhanced sensitivity to low dose irradiation of ApoE-/- mice mediated by early pro-inflammatory profile and delayed activation of the TGFβ1 cascade involved in fibrogenesis［J］.PLoS One，2013，8(2)：e57052.
［20］KISCSATRI L，SRKZY M，KVRI B，et al.High-dose radiation induced heart damage in a rat model［J］.In Vivo，2016，30(5)：623-631.
［21］AMEZIANE-EL-HASSANI R，TALBOT M，DE SOUZA DOS SANTOS MC，et al.NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation［J］.Proc Natl Acad Sci USA，2015，112(16)：5051-5056.
［22］REED GW，HORR S，YOUNG L，et al.Associations between cardiac troponin，mechanism of myocardial injury，and long-term mortality after noncardiac vascular surgery［J］.J Am Heart Assoc，2017，6(6)：e005672.
［23］D'ERRICO MP，GRIMALDI L，PETRUZZELLI MF，et al.N-terminal pro-B-type natriuretic peptide plasma levels as a potential biomarker for cardiac damage after radiotherapy in patients with left-sided breast cancer［J］.Int J Radiat Oncol Biol Phys，2012，82(2)：e239-246.
［24］CHALUBINSKA-FENDLER J，GRACZYK L，PIOTROWSKI G，et al.Lipopolysaccharide-binding protein is an early biomarker of cardiac function after radiation therapy for breast cancer［J］.Int J Radiat Oncol Biol Phys，2019，104(5)：1074-1083.
［25］FRANKENSTEIN L，WU AH，HALLERMAYER K，et al.Biological variation and reference change value of high-sensitivity troponin T in healthy individuals during short and intermediate follow-up periods［J］.Clin Chem，2011，57(7)：1068-1071.
［26］SKYTT T，TUOHINEN S，BOMAN E，et al.Troponin T-release associates with cardiac radiation doses during adjuvant left-sided breast cancer radiotherapy［J］.Radiat Oncol，2015，10：141.
［27］DONOVAN EK，DHESY-THIND S，SWAMINATH A，et al.MEDiastinal irradiation and CArdio-toxic effects(MEDICATE)：Exploring the relationship between cardiac irradiation and high sensitivity troponins［J］.Clin Oncol(R Coll Radiol)，2019，31(7)：479-485.
［28］GURSES I，OZEREN M，SERIN M，et al.Histopathological efficiency of amifostine in radiation-induced heart disease in rats［J］.Bratisl Lek Listy，2018，119(1)：54-59.
［29］BOULET J，PEA J，HULTEN EA，et al.Statin use and risk of vascular events among cancer patients after radiotherapy to the thorax，head，and neck［J］.J Am Heart Assoc，2019，8(13)：e005996.
［30］ZHANG K，HE X，ZHOU Y，et al.Atorvastatin ameliorates radiation-induced cardiac fibrosis in rats［J］.Radiat Res，2015，184(6)：611-620.
［31］VANDER VEEN SJ，GHOBADI G，DE BOER RA，et al.ACE inhibition attenuates radiation-induced cardiopulmonary damage［J］.Radiother Oncol，2015，114(1)：96-103.
［32］GU J，LIU Y，WU H，et al.Huangqi Shengmai Yin protects against radiation-induced cardiac fibrosis injury by regulating the TGF-β1/smads and MMPs［J］.Evid Based Complement Alternat Med，2019，2019：1358469.
［33］KOLIVAND S，AMINI P，SAFFAR H，et al.Evaluating the radioprotective effect of curcumin on rat's heart tissues［J］.Curr Radiopharm，2019，12(1)：23-28.
［34］SHARMA UC，SONKAWADE SD，SPERNYAK JA，et al.A small peptide Ac-SDKP inhibits radiation-induced cardiomyopathy［J］.Circ Heart Fail，2018，11(8)：e004867.
［35］YAHYAPOUR R，AMINI P，SAFFAR H，et al.Metformin protects against radiation-induced heart injury and attenuates the upregulation of dual oxidase genes following rat's chest irradiation［J］.Int J Mol Cell Med，2018，7(3)：193-202.

Memo

Memo:
海燕基金项目（编号：JJZD2017-07）
Last Update: 2020-11-30