|Table of Contents|

The expression and clinical significance of the microRNA-200a in the tissue and serum samples from the patients with endometrial adenocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
107-110
Research Field:
Publishing date:

Info

Title:
The expression and clinical significance of the microRNA-200a in the tissue and serum samples from the patients with endometrial adenocarcinoma
Author(s):
XU Jing
Department of Gynecologic Oncology,Shaanxi Provincial Cancer Hospital,Shaanxi Xi'an 710061,China.
Keywords:
endometrial adenocarcinomamicroRNA-200aserumtumor staging
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2021.01.024
Abstract:
Objective:To explore the difference of microRNA-200a expression in endometrial adenocarcinoma and its relationship with the staging of the tumor,so as to provide a new method for early detection and diagnosis of endometrial adenocarcinoma.Methods:The tissue samples from normal endometrium and endometrial adenocarcinoma patients as well as their serum sample were studied.The expression of microRNA-200a in serum and endometrial tissues was detected by PCR,and the relationship between the expression of microRNA-200a and the tumor stage of endometrial adenocarcinoma was analyzed.Results:The expression of microRNA-200a in endometrial adenocarcinoma specimens was significantly higher than that in normal endometrial tissues,with an average increase of 9.1 times(P<0.05) in tissue specimens and 5.4 times(P<0.05) in serum specimens.The serum level of microRNA-200a in patients with stage III and IV endometrial adenocarcinoma was 7.7±1.9,which was significantly higher than that in early stage(stage I and II) patients(4.2±1.9)(P<0.05).Conclusion:The expression of microRNA-200a in tissue and serum from endometrial adenocarcinoma patients is significantly higher than that of normal.It might be used as an important tumor marker for endometrial adenocarcinoma,and provide an effective method for early screening and detection of endometrial adenocarcinoma.

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Memo

Memo:
陕西省卫生科研项目(编号:2014D13)
Last Update: 2020-11-30