|Table of Contents|

The expression of Bmi-1 in endometrial carcinoma and it' s relationship with hTERT

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
103-106
Research Field:
Publishing date:

Info

Title:
The expression of Bmi-1 in endometrial carcinoma and it' s relationship with hTERT
Author(s):
QIN Rui1; GAN Jinghua1; DU Yangjun1; CHEN Xiao1; ZHAO Yuanchi2; LIANG Yuncai2; NONG Wenzheng1
1.Department of Gynecology，the Guangxi National Hospital Affiliated to Guangxi Medical University，Guangxi Nanning 530001，China；2.Department of Pathology，the People's Hospital of Chongzuo，Guangxi Chongzuo 532200，China.
Keywords:
Bmi-1; hTERT; endometrial carcinoma
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2021.01.023
Abstract:
Objective：To explore the expressions of Bmi-1 protein and hTERT in the endometrial carcinoma，atypical hyperplasia and normal endometrial tissues.Methods：Immunohistochemistrical methods were used to explore the expressions of Bmi-1 protein and hTERT in 105 cases of endometrial carcinomas which were collected，40 cases of atypical hyperplasia and 20 cases of normal endometrial tissues.Results：The postive rates of Bmi-1 protein in the endometrial carcinomas，atypical hyperplasia and normal endometrial tissue were 86.7%，55% and 25%，respectively.The positive rate of hTERT in the endometrial carcinomas，atypical hyperplasia and normal endometrial tissue were 94.3%，72.5%and 5%，respectively.The expression of Bmi-1 protein in the endometrial carcinoma and atypical hyperplasia was statistically higher than those in normal endometrial tissue（P<0.05）.In the endometrial carcinomas，the expression of Bmi-1 was associated with invasion depth and vascular invasion respectively（P<0.05).The expression of hTERT was associated with histological grade，histological types，invasion depth and vascular invasion，respectively（P<0.05).There was positive correlation between the expression of Bmi-1 protein and that of hTERT（P<0.01).Conclusion：Both Bmi-1 and hTERT are involved in the malignant transformation of endometrial lesions.The combined detection of Bmi-1 and hTERT is of certain value in early diagnosis of the occurrence and development of endometrial carcinoma.

References:

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Memo

Memo:
广西壮族自治区卫健委科研课题（编号：Z20180611）；崇左市科研项目课题（编号：崇科攻2019023）
Last Update: 2020-11-30