|Table of Contents|

Correlation analysis between endothelin-1 and CD43 in cervical cancer tissue and cervical cancer progression

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
99-102
Research Field:
Publishing date:

Info

Title:
Correlation analysis between endothelin-1 and CD43 in cervical cancer tissue and cervical cancer progression
Author(s):
LI Yandong
Department of Pathology,General Hospital,Baoan Second People's Hospital,Guangdong Shenzhen 518104,China.
Keywords:
cervical cancerendothelin-1CD34biomarker
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2021.01.022
Abstract:
Objective:To analyze the role of endothelin-1 and CD34 as indicators of the aggressiveness in cervical squamous cell carcinoma.Methods:Immunohistochemical expression of endothelin-1 and CD34 was studied in 54 paraffin-embedded tissue specimens of cervical squamous cell carcinoma.Their correlation,to the clinicopathologic features and the potential angiogenic role were analyzed.Results:Endothelin-1 overexpression was detected in 63% of the studied cases with a significant association with tumor size,FIGO stage and lymph node metastasis(P<0.01,P<0.01,P=0.03 respectively).High CD34 expression(MVD) was noted in 56% of the cases and associated with the tumor size,FIGO stage and lymph node metastasis(P<0.01,P<0.01,P=0.04 respectively).The two markers were significantly associated(P<0.05).Conclusion:Endothelin-1 and CD34 may act as biomarkers of aggressive cervical squamous cell carcinoma.

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Last Update: 2020-11-30