|Table of Contents|

The expression level of miR-802 and RAB23 in prostate cancer and their relationships with clinicopathological features and prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
89-94
Research Field:
Publishing date:

Info

Title:
The expression level of miR-802 and RAB23 in prostate cancer and their relationships with clinicopathological features and prognosis
Author(s):
GAO Yongliang1ZHANG Weixing2
1.Department of Urology,Xingyang People's Hospital,Henan Xingyang 450100,China;2.Department of Urology,First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450100,China.
Keywords:
miR-802RAB23prostate cancerclinicopathological parametersprognosis
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2021.01.020
Abstract:
Objective:To detect the expressions of microRNA(miRNA) and RAB23 in prostate cancer tissues,and to analyze their relationships with clinicopathological features and prognosis.Methods:150 patients with prostate cancer who were diagnosed and treated by radical prostatectomy in our hospital from February 2011 to February 2014 were selected as the study subjects.150 patients with benign prostatic hyperplasia who underwent electrosurgical resection at the same time were selected as the control group.The expression of RAB23 in tissues was detected by immunohistochemistry(SP).Real-time quantitative polymerase chain reaction(qRT-PCR) was used to detect the expressions of miR-802 and RAB23 in tissues.Results:The expression of microRNA-802 in prostate cancer was lower than that in benign prostatic hyperplasia(P<0.05),and the expressions of RAB23 mRNA and protein were higher(P<0.05).The expressions of miR-802 and RAB23 in prostate cancer tissues were correlated with T stage,lymph node metastasis,Gleason score and PSA level(P<0.05).Kaplan-Meier survival analysis showed that the 3-year overall survival rate of patients with high expression of miR-802 was higher than that of patients with low expression of miR-802(P<0.05).The 3-year overall survival rate of patients with high expression of RAB23 was significantly lower than that of patients with low expression of RAB23(P<0.05).Multivariate analysis showed that high Gleason score,low expression of miR-802 and high expression of RAB23 were independent risk factors for adverse prognosis(P<0.05).The expression levels of miR-802 and RAB23 in tumor tissues were negatively correlated(P<0.05).Conclusion:The expression of miR-802 is low and RAB23 is high in prostate cancer tissues.They are related to T stage,lymph node metastasis,Gleason score,PSA level and 3-year overall survival rate.High Gleason score,low expression of miR-802 and high expression of RAB23 are independent risk factors for adverse prognosis.

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Last Update: 2020-11-30