|Table of Contents|

Effects of radical gastrectomy of adenocarcinoma of the esophagogastric junction on cellular immune function

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
85-88
Research Field:
Publishing date:

Info

Title:
Effects of radical gastrectomy of adenocarcinoma of the esophagogastric junction on cellular immune function
Author(s):
ZHANG Yong; LI Shoumiao; HUANG Yumei; LI Min; CHEN Yanchao; SU Wenzhong; HU Guangjie; LI Li; HUANG Yanling
Department of Abdominal Tumor Surgery，Anyang Tumor Hospital，Henan Anyang 455000，China.
Keywords:
esophagogastric junction neoplasms; radical operation; perioperative; cellular immune
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2021.01.019
Abstract:
Objective：To evaluate cells ratios of T lymphocyte subsets and expression of programmed cell death 1(PD-1) in lymphocytes following surgery for advanced adenocarcinoma of esophagogastric junction(AEGJ)，and to understand the effect of radical surgical trauma on cellular immune function.Methods：In 126 patients with advanced AEGJ，radical open abdominal R0 resection and D2 lymphnode dissection were performed，while 87 patients with concurrent physical examination were in the control group.Peripheral blood levels of CD3+，CD3+CD4+，CD3+CD8+，CD4+CD25+T lymphocyte and expression of PD-1 in lymphocytes were measured by flow cytometry in the control group and the treatment group obtained pre- and post-operatively.Results：Compared with control group，preoperative ratios of CD3+，CD3+CD4 T cells were significantly reduced(P<0.05)，and CD4+CD25+T cells ratio add PD-1 ration in CD4+，CD8+T cells were significantly increased(P<0.05).CD4+CD25+T lymphocyte count decreased rapidly from preoperative levels，reaching a minimum on post-operative day 1 and remaining significantly increased on days 3 and 7.CD4+PD-1+T lymphocytes significantly increased，reaching a maximum on postoperative day 1 and remaining significantly elevated on day 3.CD8+PD-1+T lymphocytes significantly increased and reached a maximum on day 7.Conclusion：Surgical trauma of AEGJ may be caused by changes in the proportion of CD4+PD-1+T lymphocytes caused by various cytokines，thereby regulating the proportion of T lymphocyte subsets and inhibiting the cellular immunity.

References:

[1]李守淼，李子禹，季鑫.Siewert Ⅱ型胃食管结合部腺癌淋巴结转移的特点［J］.中华肿瘤杂志，2013，35(4)：288-291. LI SM，LI ZY，JI X.Clinical characteristics of lymph node metastasis metastasis in Siewert type Ⅱ adenocarcinoma of the gastroesophageal junction［J］.Chinese Journal of Oncology，2013，35(4)：288-291.
[2]TAKAYA S，SAITO H，IKEGUCHI M.Upregulation of immune checkpoint molecules，PD-1 and LAG-3，on CD4+and CD8+T cells after gastric cancer surgery［J］.Yonago Acta Med，2015，58(1)：39-44.
[3]ANANTH AA，TAI LH，LANSDELL C，et al.Surgical stress abrogates pre-existing protective t cell mediated anti-tumor immunity leading to postoperative cancer recurrence［J］.PLoS One，2016，11(5)：e0155947.
[4]WASIUK P，PUTOWSKI M，GIANNOPOULOS K.PD1/PD1L pathway，HLA-G and T regulatory cells as new markers of immunosuppression in cancers［J］.Postepy Hig Med Dosw(Online)，2016，70(0)：1044-1058.
[5]CHEN L，SUN L，LANG Y，et al.Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer［J］.BMC Cancer，2016(16)：449.
[6]李守淼，张志忠，张伟，等.食管胃交界部腺癌术后腹腔热灌注化疗对细胞免疫的影响［J］.中华普通外科杂志，2017，32(12)：1047-1049. LI SM，ZHANG ZZ，ZHANG W，et al.Influence of hyperthermic intraperitoneal perfusion chemotherapy on cellular immune function in adenocarcinoma of esophagogastric junction after radical operation［J］.Chinese Journal of General Surgery，2017，32(12)：1047-1049.
[7]徐志云，刘良，杨立信，等.淋巴结清扫数目对淋巴结转移阴性Siewert Ⅱ型食管胃交界部癌的影响［J］.实用医学杂志，2016，32(23)：3878-3881. XU ZY，LIU L，YANG LX，et al.Survival analysis the impact of the number of negative lymph nodes negative lymph node in Siewert Ⅱ adenocarcinoma of the esophagogastrci junction without lymphatic metastasis［J］.The Journal of Practical Medicine，2016，32(23)：3878-3881.
[8]RICE TW，PATIL DT，BLACKSTONE EH.8th edition AJCC/UICC staging of cancers of the esophagus and esophagogastric junction：Application to clinical practice［J］.Ann Cardiothorac Surg，2017，6(2)：119-130.
[9]YUAN XL，CHEN L，ZHANG TT，et al.Gastric cancer cells induce human CD4+Foxp3+regulatory T cells through the production of TGF-β1［J］.World J Gastroenterol，2011，17(15)：2019-2027.
[10]SCHMIDT A，ERIKSSON M，SHANG MM，et al.Comparative analysis of protocols to induce human CD4+Foxp3+regulatory t cells by combinations of IL-2，TGF-beta，retinoic acid，rapamycin and butyrate［J］.PLoS One，2016，11(2)：e0148474.
[11]DELEEUW RJ，KROEGER DR，KOST SE，et al.CD25 identifies a subset of CD4+FoxP3- TIL that are exhausted yet prognostically favorable in human ovarian cancer［J］.Cancer Immunol Res，2015，3(3)：245-253.
[12]PAKKALA S，OWONIKOKO TK.Immune checkpoint inhibitors in small cell lung cancer［J］.J Thorac Dis，2018，10(Suppl 3)：S460-S467.
[13]XU P，ZHANG P，SUN Z，et al.Surgical trauma induces postoperative T-cell dysfunction in lung cancer patients through the programmed death-1 pathway［J］.Cancer Immunol Immunother，2015，64(11)：1383-1392.
[14]SAITO H，KURODA H，MATSUNAGA T，et al.Increased PD-1 expression on CD4+and CD8+T cells is involved in immune evasion in gastric cancer［J］.J Surg Oncol，2013，107(5)：517-522.
[15]HASE S，WEINITSCHKE K，FISCHER K，et al.Monitoring peri-operative immune suppression in renal cancer patients［J］.Oncol Rep，2011，25(5)：1455-1464.
[16]SELLITTO A，GALIZIA G，DE FANIS U，et al.Behavior of circulating CD4+CD25+Foxp3+regulatory T cells in colon cancer patients undergoing surgery［J］.J Clin Immunol，2011，31(6)：1095-1104.
[17]WU M，CHEN X，LOU J，et al.Changes in regulatory T cells in patients with ovarian cancer undergoing surgery：Preliminary results［J］.Int Immunopharmacol，2017，47：244-250.
[18]ZHANG CH，HUANG Y.Effect of peripheral blood CD4+CD25+ regulatory T cell on postoperative immunotherapy for patients with renal carcinoma［J］.Asian Pac J Cancer Prev，2016，17(4)：2027-2030.
[19]LI Y，ZHOU L，SUN B，et al.Interleukin-2 administration after modified radical mastectomy in breast cancer therapy increases peripheral regulatory T cells［J］.Int J Clin Exp Med，2015，8(5)：7816-7822.
[20]ZHANG S，PAN SB，LYU QH，et al.Postoperative regulatory T-cells and natural killer cells in stage i nonsmall cell lung cancer underwent video-assisted thoracoscopic lobectomy or thoracotomy［J］.Chin Med J(Engl)，2015，128(11)：1502-1509.

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Last Update: 2020-11-30