|Table of Contents|

The value of lymphocyte and monocyte ratio to predict the prognosis of patients with rectum cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
77-80
Research Field:
Publishing date:

Info

Title:
The value of lymphocyte and monocyte ratio to predict the prognosis of patients with rectum cancer
Author(s):
LEI Juan1; ZHANG Hongwen1; WANG Yu2; QIU Jianshen1; HUANG Zengliang1; ZHANG Ji1; YANG Chao1; WU Weihang2
1.Interventional Ward Of Medical Imaging Center；2.Gastrointestinal Surgery，Clinical Institute of Fuzhou General Hospital，Fujian Medical University(900 Hospital of the Joint Logistics Team) Fujian Fuzhou 350025，China.
Keywords:
rectum cancer; lymphocyte and monocyte ratio; prognosis
PACS:
R735.3+7
DOI:
10.3969/j.issn.1672-4992.2021.01.017
Abstract:
Objective：To evaluate the value of lymphocyte and monocyte ratio(LMR) in predicting the prognosis of patients with rectum cancer. Methods：The 85 patients who met the criterion were enrolled to this study from January 2007 to January 2012，who were divided into high-LMR group and low-LMR group based on the standard of receiver operating characteristic curve(ROC).The relationships of LMR and clinical pathological of patients with rectum cancer was analyzed.Kaplan-Meier method was used for univariate survival and Cox hazard-ratio model was used to analyze the prognostic factors of rectum cancer. Results：The cut-off data of LMR was 4.21.The cases of high-LMR group was 58，27 in low-LMR group.The level of carcinoembryonic antigen(CEA)，the rate of cancer embolus and TNM stage were significantly different between two groups(P<0.05).However，the age，gender，type of pathological and postoperative chemotherapy and radiotherapy in two groups showed no significant differences（P>0.05）.Univariate survival analysis showed that level of CEA，the rate of cancer embolus，TNM stage and the value of LMR were risk factors for 5-year overall survival(OS) and progress free disease(PFS)（P<0.05）.The 5-year OS and PFS were 72.4%，58.6% in high-LMR group，40.7% and 25.9% in other group（P<0.05）.Cox multivariate survival analysis showed that TNM stage and LMR were independent factors for prognostic evaluation of rectum cancer patients. Conclusion：LMR level is significantly associated with TNM stage.High LMR is an independent prognostic risk factor and plays an important role in prognostic evaluation of rectum cancer patients.

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福建省科学技术厅对外合作项目（编号：2017I0015）
Last Update: 2020-11-30