|Table of Contents|

Relationship between body mass index and the clinicopathologic features of papillary thyroid carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 01
Page:
45-49
Research Field:
Publishing date:

Info

Title:
Relationship between body mass index and the clinicopathologic features of papillary thyroid carcinoma
Author(s):
CHEN Xingzhou; LIN Jing; YAN Changjiao; LING Rui; GUO Sijin
Department of Thyroid，Breast and Vascular Surgery，Xijing Hospital，Air Force Medical University，Shaanxi Xi'an 710032，China.
Keywords:
papillary thyroid carcinoma; body mass index; obesity; clinicopathologic features
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2021.01.009
Abstract:
Objective：To analyze the relationship between body mass index(BMI) and clinicopathologic features of papillary thyroid carcinoma(PTC).Methods：The medical records of 829 thyroid carcinoma patients were reviewed in this retrospective study.All patients were diagnosed at Xijing Hospital between January 2017 and June 2018.The World Health Organization BMI classification was used to classify patients as underweight(BMI＜18.5 kg/m2)，normal(18.5≤BMI＜25 kg/m2)，overweight(25≤BMI＜30 kg/m2) or obese(BMI≥30 kg/m2).The correlation was analyzed by univariate analysis and multinomial logistic regression.Results：There were significant differences between BMI and several epidemiological features，including age，gender，and history of hypertension of PTCs(P<0.001).Univariate analysis showed that BMI was significantly associated with tumor multifocality，BRAF V600E mutation，and TNM stage(P<0.05).However，no association was found between BMI and tumor size，tumor site，extrathyroidal invasion，or lymph node metastasis(P>0.05).Most of tumor was single lesion in the normal BMI group(60.3%)，and the incidence of multiple lesions was significantly increased in the non-normal group(P=0.040).With the increase of BMI，the rate of BRAF V600E mutation was significantly increased(P=0.001).The association between BMI and TNM stage was insignificant after multivariate adjustment.Conclusion：Except for multifocality，no correlation was found between aggressive clinicopathological features and BMI in PTC patients.

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Memo

Memo:
陕西省社会发展科技攻关项目（编号：2016SF-298）；西京医院助推项目（编号：XJZ15Z09）；希思科临床肿瘤学研究基金（编号：Y-BMS2019-069）
Last Update: 2020-11-30