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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2020 04

Page:

668-672

Research Field:

Publishing date:

Info

Title:

The role of cell autophagy in pathogenesis,development and therapy of prostate cancer

Author(s):

Wang Jingxiang¹; Hu Wei²; Li Xia¹

1.State Key Laboratory of Cancer Biology,Department of Biochemistry and Molecular Biology,Air Force Medical University,Shaanxi Xi'an 710032,China;2.Department of Urology,Tangdu Hospital,Air Force Medical University,Shaanxi Xi'an 710038,China.

Keywords:

autophagy; prostate cancer; progression; treatment; chemotherapy; endocrine therapy; target therapy

PACS:

R737.25

DOI:

10.3969/j.issn.1672-4992.2020.04.034

Abstract:

Autophagy is a catabolic process whereby intracellular biomacromolecules and organelles are degraded in lysosomes of eukaryotic cells£¬which plays an important role in maintenance of cellular homeostasis and mitigation of metabolic stress.Autophagy exists widely in physiological and pathological processes.Autophagy plays a dual role in tumorigenesis,which may be characterized as both tumor suppression and tumor promotion.Prostate cancer (PCa) is one of the most common malignant cancers in aged men.The researches show that autophagy is closely related to the development,progression,radiotherapy,chemotherapy and endocrinotherapy of prostate cancer.Many studies shows that autophagy inhibitors combined with androgen deprivation therapy or docetaxel is a promising approach to the treatment of prostate cancer.In this review we focus on the relationship between autophagy and PCa and the current evidence showing the capacity of autophagy inhibitors to exert their action in modulation of prostate cancer therapy.

References:

£Û1£ÝTooze SA,Dikic I.Autophagy captures the nobel prize£ÛJ£Ý.Cell,2016,167(6):1433-1435.
£Û2£ÝWhite E,Karp C,Strohecker AM,et al.Role of autophagy in suppression of inflammation and cancer£ÛJ£Ý.Curr Opin Cell Biol,2010,22(2):212-217.
£Û3£ÝYoahimori T.Autophagy:A regulated bulk degradation process inside cells£ÛJ£Ý.Biochem Biophys Res Commun,2004,313(2):453-458.
£Û4£ÝWhite E,Dipaola RS.The double-edged sword of autophagy modulation in cancer£ÛJ£Ý.Clin Cancer Res,2009,15(17):5308-5316.
£Û5£ÝSaha S,Panigrahi DP,Patil S,et al.Autophagy in health and disease:A comprehensive review£ÛJ£Ý.Biomed Pharmacother,2018(104):485-495.
£Û6£ÝLamb CA,Yoshimori T,Tooze SA.The autophagosome:Origins unknown,biogenesis complex£ÛJ£Ý.Nat Rev Mol Cell Biol,2013,14(12):759-774.
£Û7£ÝKuma A,Komatsu M,Mizushima N.Autophagy-monitoring and autophagy-deficient mice£ÛJ£Ý.Autophagy,2017,13(10):1619-1628.
£Û8£ÝKim J,Kundu M,Viollet B,et al.AMPK and mTOR regulate autophagy through direct phosphorylation of ULK1£ÛJ£Ý.Nat Cell Biol,2011,13(2):132-141.
£Û9£ÝNazio F,Cecconi F.Autophagy up and down by outsmarting the incredible ULK£ÛJ£Ý.Autophagy,2017,13(5):967-968.
£Û10£ÝXue JF,Shi ZM,Zou J,et al.Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis£ÛJ£Ý.Biomed Pharmacother,2017(89):1252-1261.
£Û11£ÝMizushima N,Komatsu M.Autophagy:Renovation of cells and tissues£ÛJ£Ý.Cell,2011,147(4):728-741.
£Û12£ÝZalckvar E,Berissi H,Eisenstein M,et al.Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL£ÛJ£Ý.Autophagy,2009,5(5):720-722.
£Û13£ÝOtomo C,Metlagel Z,Takaesu G,et al.Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy£ÛJ£Ý.Nat Struct Mol Biol,2013,20(1):59-66.
£Û14£ÝMurrow L,Debnath J.ATG12-ATG3 connects basal autophagy and late endosome function £ÛJ£Ý.Autophagy,2015,11(6):961-962.
£Û15£ÝKuma A,Komatsu M,Mizushima N.Autophagy-monitoring and autophagy-deficient mice£ÛJ£Ý.Autophagy,2017,13(10):1619-1628.
£Û16£ÝWang Y,Li L,Hou C,et al.SNARE-mediated membrane fusion in autophagy£ÛJ£Ý.Semin Cell Dev Biol,2016(60):97-104.
£Û17£ÝNakamura S,Yoshimori T.New insights into autophagosome-lysosome fusion£ÛJ£Ý.J Cell Sci,2017,130(7):1209-1216.
£Û18£ÝYu S,Melia TJ.The coordination of membrane fission and fusion at the end of autophagosome maturation£ÛJ£Ý.Curr Opin Cell Biol,2017(47):92-98.
£Û19£ÝFulda S,K¢‰gel D.Cell death by autophagy:Emerging molecular mechanisms and implications for cancer therapy£ÛJ£Ý.Oncogene,2015,34(40):5105-5113.
£Û20£ÝLevine XH,Jackson S,Seaman M,et al.Induction of autophagy and inhibition of tumorigenesis by Beclin-1£ÛJ£Ý.Nature,1999,402(6762):672-676.
£Û21£ÝMowers EE,Sharifi MN,Macleod KF.Autophagy in cancer metastasis£ÛJ£Ý.Oncogene,2017,36(12):1619-1630.
£Û22£ÝAmaravadi R,Kimmelman AC,White E.Recent insights into the function of autophagy in cancer£ÛJ£Ý.Genes Dev,2016,30(17):1913-1930.
£Û23£ÝCorcelle EA,Puustinen P,J¢|¢|ttel¢| M.Apoptosis and autophagy:Targeting autophagy signalling in cancer cells-"trick or treats"£ÛJ£Ý?FEBS J,2009,276(21):6084-6096.
£Û24£ÝHippert MM,O'Toole PS,Thorburn A.Autophagy in cancer:Good,bad or both£ÛJ£Ý?Cancer Res,2006,66(19):9349-9351.
£Û25£ÝWang H,Peng Y,Wang J,et al.Effect of autophagy on the resveratrol-induced apoptosis of ovarian cancer SKOV3 cells£ÛJ£Ý.J Cell Biochem,2019(120):7788-7793.
£Û26£ÝKung CP,Budina A,Balaburski G,et al.Autophagy in tumor suppression and cancer therapy£ÛJ£Ý.Crit Rev Eukaryot Gene Expr,2011,21(1):71-100.
£Û27£ÝDenton D,Nicolson S,Kumar S.Cell death by autophagy:Facts and apparent artefacts£ÛJ£Ý.Cell Death Differ,2012,19(1):87-95.
£Û28£ÝMarino G,Niso-Santano M,Baehrecke EH,et al.Self-consumption:The interplay of autophagy and apoptosis£ÛJ£Ý.Nat Rev Mol Cell Biol,2014,15(2):81-94.
£Û29£ÝKimmelman AC,White E.Autophagy and tumor metabolism£ÛJ£Ý.Cell Metab,2017,25(5):1037-1043.
£Û30£ÝWhite E,Mehnert JM,Chan CS.Autophagy,metabolism,and cancer£ÛJ£Ý.Clin Cancer Res,2015,21(22):5037-5046.
£Û31£ÝGuo JY,White E.Autophagy,metabolism,and cancer£ÛJ£Ý.Cold Spring Harb Symp Quant Biol,2016(81):73-78.
£Û32£ÝWestcott PM,Halliwill KD,To MD,et al.The mutational landscapes of genetic and chemical models of Kras-driven lung cancer£ÛJ£Ý.Nature,2015,517(7535):489-492.
£Û33£ÝTorre A,Bray F.Global cancer statistics£ÛJ£Ý.CA Cancer J Clin,2015(65):87-108.
£Û34£ÝBray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries£ÛJ£Ý.CA Cancer J Clin,2018,68(6):394-424.
£Û35£ÝChen W,Zheng R,Baade P,et al.Cancer statistics in China,2015£ÛJ£Ý.CA Cancer J Clin,2016,66(21):115-132.
£Û36£ÝFarrow JM,Yang JC,Evans CP.Autophagy as a modulator and target in prostate cancer£ÛJ£Ý.Nat Rev Urol,2014,11(9):508-516.
£Û37£ÝPhin S,Moore MW,Cotter PD.Genomic rearrangements of PTEN in prostate cancer£ÛJ£Ý.Front Oncol,2013(3):240.
£Û38£ÝChang L,Graham PH,Hao J,et al.PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis,reducing autophagy,suppressing NHEJ and HR repair pathways£ÛJ£Ý.Cell Death Dis,2014(5):e1437.
£Û39£ÝKlionsky DJ,Abdelmohsen K,Abe A,et al.Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) £ÛJ£Ý.Autophagy,2016,12(1):1-222.
£Û40£ÝJiang P,Mizushima N.LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells£ÛJ£Ý.Methods,2015(75):13-18.
£Û41£ÝWang L,Kim D,Wise JTF,et al.p62 as a therapeutic target for inhibition of autophagy in prostate cancer£ÛJ£Ý.Prostate,2018,78(5):390-400.
£Û42£ÝNA YQ,YE ZQ,SUN YH,et al.Chinese guidelines for the diagnosis and treatment of urological diseases£ÛM£Ý.2014th ed.Beijing:People's Health Publishing House,2014:61-89.£ÛÄÇÑåȺ,Ò¶ÕÂȺ,ËïÓ±ºÆ,µÈ.ÖйúÃÚÄòÍâ¿Æ¼²²¡Õï¶ÏÖÎÁÆÖ¸ÄÏ£ÛM£Ý.2014°æ.±±¾©£ºÈËÃñÎÀÉú³ö°æÉç,2014:61-89.£Ý
£Û43£ÝAttard G,Parker C,Eeles RA,et al.Prostate cancer£ÛJ£Ý.Lancet,2016,387(10013):70-82.
£Û44£ÝWen S,Niu Y,Lee SO,et al.Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis,anoikis,entosis,necrosis and autophagic cell death£ÛJ£Ý.Cancer Treat Rev,2014,40(1):31-40.
£Û45£ÝChhipa RR,Wu Y,Mohler JL,et al.Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress£ÛJ£Ý.Cell Signal,2010,22(10):1554-1561.
£Û46£ÝNguyen HG,Yang JC,Kung HJ,et al.Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model£ÛJ£Ý.Oncogene,2014,33(36):4521-4530.
£Û47£ÝKranzb¨¹hler B,Salemi S,Mortezavi A,et al.Combined N-terminal androgen receptor and autophagy inhibition increases the antitumor effect in enzalutamide sensitive and enzalutamide resistant prostate cancer cells£ÛJ£Ý.Prostate,2019,79(2):206-214.
£Û48£ÝMottet N,Bellmunt J,Bolla M,et al.EAU-ESTRO-SIOG guidelines on prostate cancer.Part I:Screening,diagnosis,and local treatment with curative intent£ÛJ£Ý.Eur Urol,2017,71(4):618-629.
£Û49£ÝCornford P,Bellmunt J,Bolla M,et al.EAU-ESTRO-SIOG guidelines on prostate cancer.Part II:Treatment of relapsing,metastatic,and gastration-resistant prostate cancer£ÛJ£Ý.Eur Urol,2017,71(4):630-642.
£Û50£ÝNotte A,Ninane N,Arnould T,et al.Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells:Role of autophagy and JNK activation£ÛJ£Ý.Cell Death Dis,2013,4(5):e638.
£Û51£ÝGao S,Zhao Z,Wu R,et al.miR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway£ÛJ£Ý.Aging (Albany NY),2018,10(8):2113-2121.
£Û52£ÝLiu Z,Ha US,Yu K,et al.Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway£ÛJ£Ý.J Biomed Res,2017,31(5):408-418.
£Û53£ÝHong EH,Heo EY,Song JH,et al.Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells£ÛJ£Ý.Oncotarget,2017,8(25):41401-41411.
£Û54£ÝKim SH,Park EJ,Lee CR,et al.Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells£ÛJ£Ý.Int J Oncol,2012,40(5):1683-1690.
£Û55£ÝLorente J,Velandia C,Leal JA,et al.The interplay between autophagy and tumorigenesis:Exploiting autophagy as a means of anticancer therapy£ÛJ£Ý.Biol Rev Camb Philos Soc,2018,93(1):152-165.
£Û56£ÝVeldhoen RA,Banman SL,Hemmerling DR,et al.The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis£ÛJ£Ý.Oncogene,2013,32(6):736-746.
£Û57£ÝWang Q,He WY,Zeng YZ,et al.Inhibiting autophagy overcomes docetaxel resistance in castration-resistant prostate cancer cells£ÛJ£Ý.Int Urol Nephrol,2018,50(4):675-686.
£Û58£ÝPickard RD,Spencer BH,McFarland AJ,et al.Paradoxical effects of the autophagy inhibitor 3-methyladenine on docetaxel-induced toxicity in PC-3 and LNCaP prostate cancer cells£ÛJ£Ý.Naunyn Schmiedebergs Arch Pharmacol,2015,388(7):793-799.
£Û59£ÝArchibald M,Pritchard T,Nehoff H,et al.A combination of sorafenib and nilotinib reduces the growth of castrate-resistant prostate cancer£ÛJ£Ý.Int J Nanomedicine,2016(11):179-200.
£Û60£ÝKharaziha P,Chioureas D,Baltatzis G,et al.Sorafenib-induced defective autophagy promotes cell death by necroptosis£ÛJ£Ý.Oncotarget,2015,6(35):37066-37082.
£Û61£ÝWu Z,Chang PC,Yang JC,et al.Autophagy blockade sensitizes prostate cancer cells towards src family kinase inhibitors£ÛJ£Ý.Genes Cancer,2010,1(1):40-49.
£Û62£ÝAbdel-Aziz AK,Shouman S,El-Demerdash E,et al.Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic,apoptotic and angiogenic machineries£ÛJ£Ý.Chem Biol Interact,2014(217):28-40.
£Û63£ÝWoo Y,Jung YJ.Angiotensin II receptor blockers induce autophagy in prostate cancer cells£ÛJ£Ý.Oncol Lett,2017,13(5):3579-3585.
£Û64£ÝWang B,Lu D,Xuan M,et al.Antitumor effect of sunitinib in human prostate cancer cells functions via autophagy£ÛJ£Ý.Exp Ther Med,2017,13(4):1285-1294.
£Û65£ÝZeng J,Liu W,Fan YZ,et al.PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy£ÛJ£Ý.Theranostics,2018,8(1):109-123.
£Û66£ÝHu F,Zhao Y,Yu Y,et al.Docetaxel-mediated autophagy promotes chemoresistance in castration-resistant prostate cancer cells by inhibiting STAT3£ÛJ£Ý.Cancer Lett,2018(416):24-30.
£Û67£ÝShi C,Zhang Z,Shi J,et al.Co-delivery of docetaxel and chloroquine via PEO-PPO-PCL/TPGS micelles for overcoming multidrug resistance£ÛJ£Ý.Int J Pharm,2015,495(2):932-939.
£Û68£ÝKumar D,Shankar S,Srivastava RK.Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway£ÛJ£Ý.Cancer Lett,2014,343(2):179-189.
£Û69£ÝKim KY,Park KI,Kim SH,et al.Inhibition of autophagy promotes salinomycin-induced apoptosis via reactive oxygen species-mediated PI3K/AKT/mTOR and ERK/p38 MAPK-dependent signaling in human prostate cancer cells£ÛJ£Ý.Int J Mol Sci,2017,18(5):1088-1101.

Memo

Memo:

National Natural Science Foundation of China£¨No.81872421£¬81572504£©;¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð×ÊÖúÏîÄ¿(±àºÅ£º81872421£¬81572504)

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Last Update: 2019-12-26