［1］Bray F，Ferlay J，Soerjomataram I，et al.Global cancer statistics 2018：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin，2018，68(6)：394-424.
［2］Bowen D，Joong S.Targeting epithelial-mesenchymal transition (EMT) to overcome drug resistance in cancer［J］.Molecules，2016，21(7)：965.
［3］Greenburg G，Hay ED.Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells［J］.J Cell Biol，1982(95)：333-339.
［4］Prat A，Perou CM.Desconstructing the molecular portraits of breast cancer［J］.Mol Oncol，2011(5）：5-23.
［5］Taube JH，Herschkowitz JI，Komurov K，et al.Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes［J］.Proc Natl Acad Sci USA，2010（107）：15449-15454.
［6］Micalizzi D，Ford H.Epithelial to mesenchymal transition in development of cancer［J］.Future Oncol，2009（8）：1129-1143.
［7］Felipe Lima J，Nofech-Mozes S，Bayani J.EMT in breast carcinoma-a review［J/OL］.(2016-07-14)［2019-04-22］.http：//view.pubtsg.com：8080/enpdf/201590/1893-5-27/EMT%20in%20Breast%20Carcinoma%20A%20Review%20Source%20J%20Clin%20Med%202016%20Jul%205%207［PMIDU27429011］.PDF.
［8］Sisto M，Lisi S，Ribatti D.The role of the epithelial-to-mesenchymal transition (EMT) in diseases of the salivary glands［J］.Histochem Cell Biol，2018，150(2)：133-147.
［9］Zhang L，Wang X，Lai C，et al.PMEPA1 induces EMT via a non-canonical TGF-β signalling in colorectal cancer［J］.J Cell Mol Med，2019：1-13.
［10］Weeks BH，He W，Olson KL.Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis［J］.Cancer Res，2001(61)：7435-7443.
［11］Derynck R，Lindquist PB，Lee A，et al.A new type of transforming growth factor-beta，TGF-beta 3［J］.Embo Journal，1988，7(12)：3737-3743.
［12］Gonzalez DM，Damian M.Signaling mechanisms of the epithelial-mesenchymal transition［J］.Science Signaling，2014，7(344)：re8.
［13］Yan Y，Zhang J，Li JH，et al.High tumor-associated macrophages infiltration is associated with poor prognosis and may contribute to the phenomenon of epithelial-mesenchymal transition in gastric cancer［J］.OncoTargets and Therapy，2016(9)：3975-3983.
［14］Dong M，How T，Kirkbride KC，et al.The type III TGF-beta receptor suppresses breast cancer progression［J］.Journal of Clinical Investigation，2007，117(1)：206-217.
［15］Heldin CH，Mare'ne Landstrom，Moustakas A.Mechanism of TGF-β signaling to growth arrest，apoptosis，and epithelial-mesenchymal transition［J］.Current Opinion in Cell Biology,2009，21(2)：166-176.
［16］Zhang X，Yuan X，Zhu W，et al.SALL4：An emerging cancer biomarker and target［J］.Cancer Letters，2015，357(1)：55-62.
［17］Zhang L，Xu Z，Xu X，et al.SALL4，a novel marker for human gastric carcinogenesis and metastasis［J］.Oncogene，2013，33(48)：5491-5500.
［18］Zhang X，Zhang P，Shao M，et al.SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis［J］.Cancer Manag Res，2018(10)：4459-4470.
［19］Aydin D，Bilici A，Yavuzer D，et al.Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy［J］.Clinical and Translational Oncology，2015，17(8)：604-611.
［20］Xu M，Zhou H，Zhang C，et al.ADAM17 promotes epithelial-mesenchymal transition via TGF-β/Smad pathway in gastric carcinoma cells［J］.Int J Oncol，2016(49)：2520-2528.
［21］Nianshuang L，Chuan X，Nong-Hua L.Transforming growth factor-β：An important mediator in Helicobacter pylori-associated pathogenesis［J］.Frontiers in Cellular and Infection Microbiology，2015(5)：77.
［22］Chang H，Kim N，Park JH，et al.Helicobacter pylori might Induce TGF-β1-mediated emt by means of cagE［J］.Helicobacter，2016，20(6)：438-448.
［23］Barbara M，Pilar DLP，Feda A，et al.The role of hypoxia in cancer progression，angiogenesis，metastasis，and resistance to therapy［J］.Hypoxia(Auckl)，2015(3)：83-92.
［24］Matsuoka J，Yashiro M，Doi Y，et al.Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFβ signaling［J］.PloS One，2013，8(5)：e62310.
［25］Jian-Kai W，Wen-Juan W，Hong-Yi C，et al.MFAP2 promotes epithelial-mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway［J］.OncoTargets and Therapy，2018(11)：4001-4017.
［26］Ouyang S，Zhu G，Ouyang L，et al.Bapx1 mediates transforming growth factor-β-induced epithelial-mesenchymal transition and promotes a malignancy phenotype of gastric cancer cells［J］.Biochemical and Biophysical Research Communications，2017，486(2)：285-292.
［27］Li F，Shi J，Xu Z，et al.S100A4-MYH9 axis promote migration and invasion of gastric cancer cells by inducing TGF-β-Mediated epithelial-mesenchymal transition［J］.J Cancer，2018(9)：3839-3849.
［28］Cieply B，Riley P，Pifer PM，et al.Suppression of the epithelial-mesenchymal transition by grainyhead-like-2［J］.Cancer Res，2012，72(9)：2440-2453.
［29］Xiang J，Fu X，Ran W，et al.Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer［J］.Oncogenesis，2017，6(1)：e284.
［30］Stojanovic J，Tognetto A，Tiziano DF，et al.MicroRNAs expression profiles as diagnostic biomarkers of gastric cancer：A systematic literature review［J］.Biomarkers，2018：1-10.
［31］Zhang W.miR-148a downregulates the expression of transforming growth factor-β2 and SMAD2 in gastric cancer［J］.Int J Oncol，2016(48)：1877-1885.
［32］Li Q，Peng J，Li X，et al.miR-449a targets Flot2 and inhibits gastric cancer invasion by inhibiting TGF-β-mediated EMT［J］.Diagnostic Pathology，2015，10(1)：202.
［33］Zhou N，Liu C，Wang X，et al.Downregulated SASH1 expression indicates poor clinical prognosis in gastric cancer［J］.Hum Pathol，2018(74）：83-91.
［34］Zong W，Yu C，Wang P.Overexpression of SASH1 inhibits TGF-β1-Induced EMT in gastric cancer cells［J］.Oncol Res，2016（24）：17-23.
［35］Neuzillet C，Tijeras-Raballand A，Cohen R，et al.Targeting the TGFβ pathway for cancer therapy［J］.Pharmacol Ther，2015（147）：22-31.
［36］He Z，Dong W，Li Q，et al.Sauchinone prevents TGF-β-induced EMT and metastasis in gastric cancer cells［J］.Biomedicine & Pharmacotherapy，2018（101）：355-361.
［37］Wu TT，Lu J，Zheng PQ，et al.Yiqi huayu jiedu decoction inhibits the invasion and metastasis of gastric cancer cells through TGF-β/smad pathway［J］.Evid Based Complement Alternat Med，2017（2017）：1871298.
［38］Zhu J，Wen K.Astragaloside IV inhibits TGF-β1-induced epithelial-mesenchymal transition through inhibition of the PI3K/Akt/NF-κB pathway in gastric cancer cells［J］.Phytother Res，2018，32(7)：1289-1296.