|Table of Contents|

Research progress of perioperative immune function protection in lung cancer patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
512-516
Research Field:
Publishing date:

Info

Title:
Research progress of perioperative immune function protection in lung cancer patients
Author(s):
Yang YangSui Tiequan
Department of Thoracic Surgery,Tianjin Fifth Central Hospital,Tianjin 300450,China.
Keywords:
lung cancerperioperative periodimmune protection
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.03.039
Abstract:
The cellular immunity,humoral immunity and erythrocyte immunity of lung cancer patients are all lower in different degrees than normal.At present,the first choice of treatment for lung cancer in early and middle stage patients is still surgical resection.Although resection of the tumor can alleviate the immunosuppression caused by the tumor itself,the stress response caused by surgical trauma,neuroendocrine changes,pain stimulation and the use of narcotic drugs will aggravate the immunosuppression in a period of time after surgery.Therefore,the improvement of multiple treatment links during the perioperative period can help to promote the recovery of postoperative immune function and reduce the probability of tumor recurrence and metastasis.Specific measures include giving Shenqi Fuzheng Injection,lycopene,thymosin and other drugs before operation and giving appropriate psychological counseling in advance to enhance immunity.During the operation,minimally invasive video-assisted thoracoscopic techniques more frequently is used and epidural anesthesia and general anesthesia are combined.In the perioperative period,multiple modes of combined analgesia are used.Preemptive analgesia with non-steroidal anti-inflammatory drugs such as flurbiprofen axetil is used before operation.After surgery,continuous patient-controlled intravenous analgesia with adjuvant drugs such as dezocine or combined with intercostal nerve block is used,or other methods such as patient-controlled epidural analgesia and patient-controlled paraspinal nerve block for analgesia are used.Besides,patients shoule receive early postoperative nutritional support.Unnecessary blood transfusion is minimized,and irradiated component transfusion can be used when blood transfusion is really needed.

References:

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