［1］Williams CB，Yeh ES，Soloff AC.Tumor-associated macrophages：Unwitting accomplices in breast cancer malignancy［J］.Npj Breast Cancer，2016(2):15025.
［2］Chanmee T，Ontong P，Konno K，et al.Tumor-associated macrophages as major players in the tumor microenvironment［J］.Cancers，2014，6(3)：1670.
［3］Davis MJ，Tsang TM，Qiu Y，et al.Macrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in cryptococcus neoformans infection［J］.mBio，2013，4(3)：e00264-00213.
［4］Lin YW，Lee B，Liu PS，et al.Receptor-interacting protein 140 orchestrates the dynamics of macrophage M1/M2 polarization［J］.Journal of Innate Immunity，2016，8(1)：97-107.
［5］Roszer T.Understanding the mysterious M2 macrophage through activation markers and effector mechanisms［J］.Mediators of Inflammation，2015(2015):816460.
［6］Lu G，Zhang R，Geng S，et al.Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization［J］.Nature Communications，2015(6):6676.
［7］Mitchell RE，Hassan M，Burton BR，et al.IL-4 enhances IL-10 production in Th1 cells：implications for Th1 and Th2 regulation［J］.Scientific Reports，2017，7(1)：11315.
［8］Xie C，Liu C，Wu B，et al.Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function［J］.International Journal of Molecular Medicine，2016，38(1)：148-160.
［9］Unver N，DElgado O，Zeleke K，et al.Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol［J］.International Journal of Cancer，2017，142(7)：1405-1417.
［10］Wu W，Lin L，Yao H，et al.A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis［J］.Cancer Cell，2014，25(2)：22.
［11］Balamurugan K.HIF-1 at the crossroads of hypoxia，inflammation，and cancer［J］.International Journal of Cancer，2016，138(5)：1058-1066.
［12］Liu Y，Cao X.The origin and function of tumor-associated macrophages［J］.Cellular and Molecular Immunology，2015，12(1)：1-4.
［13］Wang Q，He Z，Huang M，et al.Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α［J］.Nature Communications,2018，9(1)：559.
［14］Kumar V，Cheng P，Condamine T，et al.CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation［J］.Immunity，2016，44(2)：303-315.
［15］Sierra-filardi E，Nieto C，Domínguez-soto A，et al.CCL2 shapes macrophage polarization by GM-CSF and M-CSF：identification of CCL2/CCR2-dependent gene expression profile［J］.The Journal of Immunology，2014，192(8)：3858.
［16］Guo X，Zhao Y，Yan H，et al.Single tumor-initiating cells evade immune clearance by recruiting type II macrophages［J］.Genes & Development，2017，31(3)：247-259.
［17］Patsialou A，Wang Y，Pignatelli J，et al.Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGFβ in claudin-low breast tumor cells［J］.Oncogene，2014(34):2721.
［18］Henze AT，Mazzone M.The impact of hypoxia on tumor-associated macrophages［J］.The Journal of Clinical Investigation，2016，126(10)：3672-3679.
［19］Yang Y，Andersson P，Hosaka K，et al.The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages［J］.Nature Communications，2016(7）：11385.
［20］Hahne M，Schumann P，Mursell M，et al.Unraveling the role of hypoxia-inducible factor (HIF)-1α and HIF-2α in the adaption process of human microvascular endothelial cells (HMEC-1) to hypoxia：Redundant HIF-dependent regulation of macrophage migration inhibitory factor［J］.Microvascular Research，2018(116)：34-44.
［21］Zhang J，Zhang Q，Lou Y，et al.Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment［J］.Hepatology,2018，67(5)：1872-1889.
［22］Dwyer AR，Greenland EL，Pixley FJ.Promotion of tumor invasion by tumor-associated macrophages：The role of CSF-1-activated phosphatidylinositol 3 kinase and src family kinase motility signaling［J］.Cancers，2017，9(6)：68.
［23］Noy R，Pollard JW.Tumor-associated macrophages：from mechanisms to therapy［J］.Immunity，2014，41(1)：49.
［24］Zhu J，Zhou BP，Tao M，et al.The role of tumor associated macrophages in the tumor microenvironment：mechanism and functions［J］.Anticancer Agents Med Chem，2016，16(9)：1133-1141.
［25］Linde N，Casanova-acebes M，Sosa MS，et al.Macrophages orchestrate breast cancer early dissemination and metastasis［J］.Nature Communications，2018，9(1)：21.
［26］Che F，Heng X，Zhang H，et al.Novel B7-H4-mediated crosstalk between human non-Hodgkin lymphoma cells and tumor-associated macrophages leads to immune evasion via secretion of IL-6 and IL-10［J］.Cancer Immunology，Immunotherapy，2017，66(6)：717-729.
［27］Qi W，Yong T，Yu H，et al.CCL18 from tumor-cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway［J］.Molecular Carcinogenesis，2016，55(11)：1688-1699.
［28］Goswami KK，Ghosh T，Ghosh S，et al.Tumor promoting role of anti-tumor macrophages in tumor microenvironment［J］.Cellular Immunology，2017（316）：1-10.
［29］Lin H，Wei S，Hurt E M，et al.Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression［J］.The Journal of Clinical Investigation，2018，128(2)：805-815.
［30］Harada K，Dong X，Estrella JS，et al.Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma［J］.Gastric Cancer，2018，21(1)：31-40.
［31］Prima V，KAliberova LN，Kaliberov S，et al.COX2/mPGES1/PGE<；sub>；2<；/sub>；pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells［J］.Proceedings of the National Academy of Sciences，2017，114(5)：1117.
［32］Jinushi M，Chiba S，Yoshiyama H，et al.Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells［J］.Proceedings of the National Academy of Sciences of the United States of America，2011，108(30)：12425-12430.
［33］Smith MP，Sanchez-laorden B，Brien K，et al.The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα［J］.Cancer Discovery，2014，4(10)：1214.
［34］Arlauckas SP，Garris CS，Kohler RH，et al.In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy［J］.Science Translational Medicine，2017，9(389).doi:10.1126/scitranslmed.aal3604.
［35］Xu J，Escamilla J，Mok S，et al.CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy［J］.Cancer Research，2013，73(9)：2782-2794.