|Table of Contents|

Potential role of chemokine CCL8 in cancer progression

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
500-503
Research Field:
Publishing date:

Info

Title:
Potential role of chemokine CCL8 in cancer progression
Author(s):
Wang Ran1Mao Rui2Guo Haoyue1Zhu Erjia2Chen Donglai2Chen Chang2
1.Department of Thoracic Surgery,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China;2.Tongji University School of Medicine,Shanghai 200092,China.
Keywords:
chemokine CCL8neoplasmstumor microenvironment
PACS:
R730.2
DOI:
10.3969/j.issn.1672-4992.2020.03.036
Abstract:
Chemokine CCL8 is a member of the CC chemokine family,and it plays an important role in inflammation response and tumor immunity.Recently,accumulated evidence shows an intimate correlation between CCL8 and the development of human cancer.CCL8 serves as an indispensable part in the tumor microenvironment.On the one hand,it promotes the infiltration and metastasis of tumor cells,on the other hand,it would suppress the tumor progression.This review highlights the current knowledge about the role of CCL8 in oncology,including tumor progression,infiltration,metastasis and so on.The researches of CCL8 in tumor will help us comprehend more about the mechanism of neoplastic processes,and help with the discovery of more effective therapeutics of cancer.

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