|Table of Contents|

New ideas and challenges on the correlation between metformin and tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
486-489
Research Field:
Publishing date:

Info

Title:
New ideas and challenges on the correlation between metformin and tumor
Author(s):
Li PuQiao Hong
Department of Endocrinology,the Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150086,China.
Keywords:
metformindiabetes mellituscancertumourchemotherapeuticprevention and treatmentprognosis
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2020.03.032
Abstract:
Type 2 diabetes mellitus (T2DM) is a chronic disease,and it is rapidly growing in worldwide and is an important risk factor for various types of cancer.Metformin is the most commonly prescribed drug for type 2 diabetes mellitus.Epidemiological and clinical observation studies have shown that metformin use reduces risk of cancer in patients with type 2 diabetes mellitus and improves prognosis and survival rate of the cancer patients.Furthermore,ongoing clinical trials of metformin in cancer therapy are extending to nondiabetic population.A growing number of researchers believe that metformin will become an attractive candidate for cancer prevention and treatment.This review summarizes recent epidemiological evidence and progress in studies of metformin use in cancer,mechanism of metformin's anticancer effect and discusses the possibility to enhance its sensitivity to tumors and to prevent cancer metastasis.

References:

[1]Pernicova I,Korbonits M.Metformin-mode of action and clinical implications for diabetes and cancer[J].Nat Rev Endocrinol,2014,10(3):143-156.
[2]Evans JM,Donnelly LA,Emslie-Smith AM,et al.Metformin and reduced risk of cancer in diabetic patients[J].BMJ,2005,330(7503):1304-1305.
[3]Lu MZ,Li DY,Wang XF.Effect of metformin use on the risk and prognosis of ovarian cancer:An updated systematic review and meta-analysis[J].Panminerva Med,2019,18(1):364-367.
[4]Morales DR,Morris AD.Metformin in cancer treatment and prevention[J].Annual Review of Medicine,2015,66(1):17-29.
[5]Chu D,Wu J,Wang K,et al.Effect of metformin use on the risk and prognosis of endometrial cancer:A systematic review and meta-analysis[J].BMC Cancer,2018,18(1).doi:10.1186/s12885-018-4334-5.
[6]Gandini S,Puntoni M,Heckman-Stoddard BM,et al.Metformin and cancer risk and mortality:A systematic review and meta-analysis taking into account biases and confounders[J].Cancer Prev Res(Phila),2014,7(9):867-885.
[7]Parikh AB,Kozuch P,Rohs N,et al.Metformin as a repurposed therapy in advanced non-small cell lung cancer(NSCLC):Results of a phase Ⅱ trial[J].Invest New Drugs,2017(35):813-819.
[8]Miranda VC,Braghiroli MI,Faria LD,et al.Phase 2 trial of metformin combined with 5-Fluorouracil in patients with refractory metastatic colorectal cance[J].Clin Colorectal Cancer,2016,15(4):321-328.
[9]Sivalingam VN,Kitson S,McVey R,et al.Measuring the biological effect of presurgical metformin treatment in endometrialcancer[J].Br J Cancer,2016,114(3):281-289.
[10]Martinez JA,Chalasani P,Thomson CA,et al.Phase II study of metformin for reduction of obesity-associated breast cancer risk:A randomized controlled trial protocol[J].BMC Cancer,2016(16):500.
[11]Cai D,Sun H,Qi Y,et al.Insulin-like growth factor 1/mammalian target of rapamycin and amp-activated protein kinase signaling involved in the effects of metformin in the human endometrial cancer[J].Gynecol Cancer,2016,26(9):1667-1672.
[12]Qian W,Li J,Chen K,et al.Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer[J].Life Sci,2018,S0024-3205(18):30432-30436.
[13]Li L,Jiang L.Combination of metformin and gefitinib as first-line therapy for non-diabetic advanced NSCLC patients with EGFR mutations:A randomized,double-blind phase 2 trial[J].Clin Cancer Res,2019(19):0437-0439.
[14]Wenxiu X,Xiaowei Z,Haiying D,et al.Impact of metformin use on survival outcomes in non-small cell lung cancer treated with platinum[J].Medicine,2018,97(51).doi:10.1097/MD.0000000000013652.
[15]Zhang J,Wu J.The prognostic value of metformin for advanced non-small cell lung cancer:A systematic review and meta-analysis[J].Transl Lung Cancer,2018,7(3):389-396.
[16]Hirsch HA,Iliopoulos D,Tsichlis PN,et al.Metformin selectively targets cancer stem cells,and acts together with chemotherapy to block tumor growth and prolong remission[J].Cancer Research,2009,69(19):7507-7511.
[17]Zhao Z,Cheng X,Wang Y,et al.Metformin Inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis[J].PLOS ONE,2014:9.
[18]Zhang J,Shen C,Wang L,et al.Metformin inhibits epithelial-mesenchymal transition in prostate cancer cells:Involvement of the tumor suppressor miR30a and its target gene SOX4[J].Biochemical and Biophysical Research Communications,2014,452(3):746-752.
[19]Duque JE,Cruz N,Samudio I,et al.Antitumor mechanisms of metformin:Signaling,metabolism,immunity and beyond[J].Universitas Scientiarum,2010,15(2):122-129.
[20]Lei Y,Yi Y,Liu Y,et al.Metformin targets multiple signaling pathways in cancer[J].Chin J Cancer,2017,36(1):17.
[21]Abo-Elmatty DM,Ahmed EA,Tawfk MK,et al.Increased soluble CD155 in the serum of cancer patients[J].Plos One,2016,11(4):e0152982.
[22]Luengo A,Sullivan LB,Heiden MGV.Understanding the complex-I-ty of metformin action:limiting mitochondrial respiration to improve cancer therapy[J].BMC Biology,2014,12(1):82.
[23]Levy A,Doyen J.Metformin for non-small cell lung cancer patients:Opportunities and pitfalls[J].Crit Rev Oncol Hematol,2018(125):41-47.
[24]Eikawa S,Nishida M,Mizukami S,et al.Immune-mediated antitumor effect by type 2 diabetes drug,metformin[J].Proc Natl Acad Sci USA,2015,112(6):1809-1814.
[25]Daugan M,Dufay Wojcicki A,d'Hayer B,et al.Metformin:An anti-di-abetic drug to fight cancer[J].Pharmacol Res,2016,113(Pt A):675-685.
[26]Shackelford D,Abt E,Gerken L,et al.LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin[J].Cancer Cell,2013,23(2):143-158.
[27]Birsoy K,Possemato R,Lorbeer FK,et al.Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides[J].Nature,2014,508(7494):108-112.
[28]Kuo CL,Hsieh Li SM.The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte[J].Cancer Manag,2019,15(11):6567-6579.
[29]Liu C,Wang F,Fan QX,et al.Advances of clinical trials of metformin in antitumor therapy[J].Chin J Clin Oncol,2018,45(20):189-193.
[30]Yang C,Zhao N.Metformin improves the sensitivity of ovarian cancer cells to chemotherapeutic agents[J].Oncol Lett,2019,18(3):2404-2411.
[31]Meireles CG,Pereira SA,Valadares LP,et al.Effects of metformin on endometrial cancer:Systematic review and meta-analysis[J].Gynecol Oncol,2017,147(1):167-180.

Memo

Memo:
National Natural Science Foundation of China(No.81673108,81872560);国家自然科学基金资助项目(编号:81673108,81872560)
Last Update: 1900-01-01