|Table of Contents|

Comparison of clinical efficacy between microtransplantation combined with chemotherapy and chemotherapy alone in the treatment of patients with high-risk myelodysplastic syndrome

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
447-450
Research Field:
Publishing date:

Info

Title:
Comparison of clinical efficacy between microtransplantation combined with chemotherapy and chemotherapy alone in the treatment of patients with high-risk myelodysplastic syndrome
Author(s):
Tang YuanyanXiong TaoLiang YanYu ZhuojunLiu MinZhang JiangzhaoHuang Zhiping
Department of Hematology,Jingzhou Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Hubei Jingzhou 434020,China.
Keywords:
myelodysplastic syndromedecitabinemicrotransplantation
PACS:
R733.3
DOI:
10.3969/j.issn.1672-4992.2020.03.021
Abstract:
Objective:To compare the clinical efficacy and adverse reactions of microtransplantation combined with decitabine and modified HAG regimen and chemotherapy alone in high-risk myelodysplastic syndrome.Methods:33 high-risk MDS patients were divided into two groups:Microtransplantation combined with decitabine and modified HAG regimen group(n=21) and chemotherapy alone group(n=12).Clinical efficacy,adverse reactions and treatment results were observed and analyzed.Results:14/21(66.7%) patients of microtransplantation group achieved complete remission,3/12(25.0%) patients of chemotherapy alone group achieved complete remission.There was statistically significant difference between microtransplantation group and chemotherapy alone group.The median recovery time for granulocyte was 13 days and 15.5 days in the patients with microtransplantation group and chemotherapy alone group respectively.The median recovery time for platelet was 16 days and 18 days in the patients with microtransplantation group and chemotherapy alone group respectively.There was statistically significant difference between microtransplantation group and chemotherapy alone group.The 12-month OS rate of the patients with microtransplantation group and chemotherapy alone group were 90.5% and 50.0%.The 24-month OS rate of the patients with microtransplantation group and chemotherapy alone group 81.0% and 41.7%.The 12-month PFS rate of the patients with microtransplantation group and chemotherapy alone group were 57.1% and 41.7%.The 24-month PFS rate of the patients with microtransplantation group and chemotherapy alone group were 42.9% and 25.%.Conclusion:Microtransplantation combined with decitabine and modified HAG regimen may provide a novel,effective,and safe treatment for high-risk MDS patients.

References:

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