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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2020 03

Page:

421-425

Research Field:

Publishing date:

Info

Title:

Clinical analysis of CT-guided radiofrequency thermocoagulation of celiac plexus in the treatment of advanced pancreatic cancer with intractable pain

Author(s):

Wang Xinlin¹; Wen Yurong¹; Xiao Bing¹; Wei Xuan²; Wang Yingfeng²; Nan Ping²; Gou Qiuxia²; Li Beilei²

1.Department of Interventional Oncology，Third People's Hospital of Gansu Province，Gansu Lanzhou 730000，China；2.Intervention Department，People's Liberation Army Joint Logistics Support Force 940 Hospital，Gansu Lanzhou 730050，China.

Keywords:

pancreatic cancer; intractable pain; CT guidance; radiofrequency thermocoagulation of celiac plexus

PACS:

R735.9

DOI:

10.3969/j.issn.1672-4992.2020.03.015

Abstract:

Objective：To explore the clinical analgesic effect of CT-guided radiofrequency ablation of abdominal plexus in the treatment of advanced pancreatic cancer with intractable pain.Methods：70 patients with advanced pancreatic cancer with intractable pain from June 2016 to June 2018 were enrolled in the study.They were divided into control group and observation group by 35 patients according to the random number table method.Control group received fentanyl transdermal patch 4.125 mg/paste×2/72 h topical+gabapentin capsule 200 mg po 3/d.Observation group received CT-guided abdominal plexus radiofrequency thermocoagulation.Radiofrequency treatment parameters were 3 min，70 ℃.Analgesic efficacy in patients with advanced pancreatic cancer with intractable pain was evalulated.Results：The VAS scores of the two groups were decreased at 3 d，6 d，21 d and 60 d after treatment (P<0.05)，and the VAS scores of the observation group were lower than those of the control group at each time point after treatment.The pain relief rate was higher than that of the control group.The difference was statistically significant (P<0.05).There were no significant differences in preoperative physical function scores，emotional function scores，social function scores，and total health status scores between the two groups (P>0.05).At 3 d，6 d，21 d and 60 d after treatment，the physical function score，emotional function score and social function score of the observation group showed a downward trend，and the total health status score showed an upward change.The difference between the two groups was statistically significant (P<0.05).There was no significant difference in serum TNF-α，IL-6 and CRP between the two groups before the treatment of serum inflammatory factors (P>0.05).The levels of serum TNF-α，IL-6 and CRP in the observation group were significantly lower than those in the control group at 1 and 3 days after treatment.The difference between the two groups was statistically significant (P<0.05).Conclusion：CT-guided radiofrequency thermocoagulation of the celiac plexus is effective in the treatment of advanced pancreatic cancer with intractable pain and analgesia.It is simple in operation，less invasive，quick in effect，safe and effective.

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