|Table of Contents|

Prognostic factors for the survival of extensive stage small cell lung cancer in elderly patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
411-415
Research Field:
Publishing date:

Info

Title:
Prognostic factors for the survival of extensive stage small cell lung cancer in elderly patients
Author(s):
Cao Heng1Song Xuekun2Hong Yonggui1
1.Department of Oncology,Anyang Tumor Hospital,The Fourth Affiliated Hospital of Henan University of Science and Technology,Henan Anyang 455000,China;2.School of Information Technology,Henan University of Chinese Traditional Medicine,Henan Zhengzhou 450000,China.
Keywords:
small cell lung cancerextensive stageelderlysurvival rateprognosis
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.03.013
Abstract:
Objective:To investigate prognostic factors associated with survival of patients with extensive stage small cell lung cancer (ES-SCLC) in elderly patients.Methods:Clinical data from 60 cases elderly patients with ES-SCLC who were diagnosed through histopathology or cytology between June 2010 and June 2015 in Anyang Tumor Hospital were analyzed.Kaplan-Meier,Log-rank test and Cox proportional hazards regression analysis were preformed to make univariate and multivariate analysis.Results:The 1-year,2-year,3-year overall survival rates of 60 cases elderly patients with ES-SCLC were 38.3%,8.3% and 3.3%,respectively.The median survival time(MST) of patients was 10.0 months.Univariate analysis indicated that age,ECOG score,efficacy of first-line chemotherapy,the total number of cycles of chemotherapy,hepatic metastasis and chronic disease were significantly influenced survival of elderly patients with ES-SCLC(P<0.05).The multivariate analysis suggested that age,ECOG score,efficacy of first-line chemotherapy,the total number of cycles of chemotherapy,and hepatic metastasis were independent prognostic factors of survival.Conclusion:The efficacy of age,ECOG score,efficacy of first-line chemotherapy,the total number of cycles of chemotherapy,and hepatic metastasis are important prognostic factors for elderly patients with ES-SCLC.

References:

[1]Van Meerbeeck JP,Fennell DA,De Ruysscher DK.Small-cell lung cancer[J].The Lancet,2011,378(4):1741-1755.
[2]SHAO WP,WANG XW,LIU DR.Recent advances and future strategies for small cell lung cancer[J].Chin J Lung Cancer,2017,20(6):421-426.[邵为朋,王晓伟,刘德若.小细胞肺癌目前治疗的策略与未来方向[J].中国肺癌杂志,2017,20(6):421-426.]
[3]Detterbeck FC,Chansky K,Groome P,et al.The IASLC lung cancer staging project:methodology and validation used in the development of proposals for revision of the stage classification of NSCLC in the forthcoming(eighth) edition of the TNM classification of lung cancer[J].J Thorac Oncol,2016,11(9):1433-1446.
[4]Neal JW,Gubens MA,Wakelee HA.Current management of small cell lung cancer[J].Clin Chest Med,2011,32(4):853-863.
[5]Tay FR,Pashley DH.Resin bonding to cervical sclerotic dentin:A review[J].J Dent,2004,32(3):173-196.
[6]Yoshiyama M,Sano H,Ebisu S,et al.Regional strengths of bonding agents to cervical sclerotic root dentin[J].J Dental Res,1996,75(6):1404-1413.
[7]Lally BE,Geigeg AM,Urbanic JJ,et al.Trends in the outcomes for patients with limited stage small cell lung cancer:An analysis of the surveillance,epidemiology and end results database[J].Lung Cancer,2009,64(2):226-231.
[8]Janssen-Heijnen ML,Maas HA,van de Schans SA,et al.Chemotherapy in elderly small cell lung cancer patients:Yes we can,but should we do it[J]?Ann Oncol,2011,22(4):821-826.
[9]Hatfield LA,Haiden A,Lamont EB,et al.Survival and toxicity after cisplatin plus etoposide versus carboplatin plus etoposide for extensive stage small cell lung cancer in elderly patients[J].J Oncol Pract,2016,12(7):666-673.
[10]Laura C Caprario,David M Kent,Gary M Strauss,et al.Effects of chemotherapy on survial of elderly patients with small cell lung cancer:Analysis of the SEER-medicare database[J].J Thorac Oncol,2013,8(10):1272-1281.
[11]MA MJ,WANG MZ,XU Y,et al.First-line chemotherapy and its survival analysis of 394 patients with extensive-stage small cell lung cancer in a single institute[J].Chin J Lung Cancer,2014,17(1):8-14.[马满娇,王孟昭,徐燕,等.单中心394例广泛期小细胞肺癌的一线化疗及生存分析[J].中国肺癌杂志,2014,17(1):8-14.]
[12]Sharma N,Pennell N,Nickolich M,et al.Phase II trial of sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer[J].Invest New Drugs,2014,32(2):362-368.
[13]Abdelraouf F,Smit E,Hasan B,et al.Sunitinib(SU11248)in patients with chemo naive extensive small cell lung cancer or who have a "chemosensitive" relapse:A single arm phase Ⅱ study(EORTC-08061)[J].Eur J Cancer,2016,54(1):35-39.
[14]Trafalis DT,Alifieris C,Stathopoulos GP,et al.Phase Ⅱ study of bevacizumab plus irinotecan on the treatment of relapsed resistant small cell lung cancer[J].Cancer Chemother Pharmacol,2016,77(4):713-722.
[15]Horn L,Mansfield AS,Szczesna A,et al.First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer[J].N Engl J Med,2018,379(23):2220-2229.

Memo

Memo:
National Natural Science Foundation of China(No.61702164);国家自然科学基金(青年科学基金项目)(编号:61702164)
Last Update: 1900-01-01