|Table of Contents|

Inhibitory effect of gemcitabine combined with cisplatin on tumor in rats with lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 03
Page:
387-391
Research Field:
Publishing date:

Info

Title:
Inhibitory effect of gemcitabine combined with cisplatin on tumor in rats with lung cancer
Author(s):
Li Xiaodong1Liu Qingxiang2
1.Department of Radiology£¬the Third Hospital of Chengde£¬Hebei Chengde 067000£¬China£»2.Department of Radiology£¬Chengde Central Hospital£¬Hebei Chengde 067000£¬China.
Keywords:
docetaxelcisplatininterventional therapylung cancer
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.03.008
Abstract:
Objective£ºTo compare the inhibitory effects of gemcitabine combined with cisplatin on tumor growth in rats with lung cancer.Methods£º40 rats were randomly divided into blank control group£¬normal saline (NS) group£¬intravenous chemotherapy group and arterial chemotherapy group.The changes of tumor volume£¬tumor inhibition rate and the expression of Bcl-2 and Caspase-3 protein were detected.Results£ºWith the prolongation of treatment time£¬the tumor volume of the blank control group and NS group increased gradually£¬the tumor volume of intravenous chemotherapy group and arterial chemotherapy group decreased gradually£¬and with the prolongation of administration time£¬the inhibition effect advantage became more obvious.The tumor inhibition rate (57.6%) in arterial chemotherapy group was higher than intravenous chemotherapy group (42.4%).Western-blot showed that the expression of Caspase-3 protein increased and the expression of Bcl-2 protein decreased in intravenous chemotherapy group and arterial chemotherapy group compared with the blank control group and NS group.The expression of Bcl-2 protein was lowest and Caspase-3 protein was highest in arterial chemotherapy group.There were apoptotic cells in intravenous chemotherapy group and arterial chemotherapy group,and the apoptotic cells ratio was higher in arterial chemotherapy group.Ki-67 positive expression was found in all the tumors of the four groups.The proliferation coefficient of Ki-67 in the blank control group and NS group was higher than that in the intravenous chemotherapy group£¬and the proliferation coefficient of Ki-67 in the arterial chemotherapy group was the lowest.Conclusion£ºGemcitabine combined with cisplatin in arterial chemotherapy group is more effective in inhibiting tumor growth than intravenous chemotherapy.

References:

£Û1£ÝLIN YL£¬WU XQ£¬LIN TQ.Trend analysis and prediction of lung cancer death and life loss in Xiamen£ÛJ£Ý.Chinese Journal of Lung Cancer£¬2016£¬19(2)£º77-81.£ÛÁÖÒÕÀ¼£¬ÎéÐ¥Ç࣬ÁÖÌïȪ.ÏÃÃÅÊоÓÃñ·Î°©ËÀÍöÓë¼õÊÙÇ÷ÊÆ·ÖÎö¼°Ô¤²â£ÛJ£Ý.Öйú·Î°©ÔÓÖ¾£¬2016£¬19(2)£º77-81.£Ý
[2]Kim ES£¬Kim YT£¬Kang CH£¬et al.Prevalence of and risk factors for postoperative pulmonary complications after lung cancer surgery in patients with early-stage COPD£ÛJ£Ý.International Journal of Chronic Obstructive Pulmonary Disease£¬2016£¬11(1)£º1317-1326.
[3]Rosell R£¬Dafni U£¬Felip E£¬et al.Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF)£ºAn international£¬multicentre£¬single-arm£¬phase 2 trial£ÛJ£Ý.Lancet Respir Med£¬2017£¬5(5)£º435-444.
[4]MA YJ£¬GAO T£¬DANG Y£¬et al.Clinical efficacy of bronchoscopic intervention combined with external radiation therapy for central lung cancer£ÛJ£Ý.Journal of Clinical Lung£¬2017£¬22(1)£º174-175.£ÛÂíÓñ¾ê£¬¸ßͤ£¬µ³ìÍ£¬µÈ.¾­Ö§Æø¹Ü¾µ½éÈëÁªºÏÌåÍâ·ÅÉäÖÎÁÆÖÐÑëÐͷΰ©µÄÁÙ´²ÁÆÐ§£ÛJ£Ý.ÁÙ´²·Î¿ÆÔÓÖ¾£¬2017£¬22(1)£º174-175.£Ý
[5]Miller DA£¬Krasna MJ.Local therapy indications in the management of patients with oligometastatic non-small cell lung cancer£ÛJ£Ý.Surgical Oncology Clinics of North America£¬2016£¬25(3)£º611-620.
[6]Paccagnella A£¬Oniga F£¬Bearz A£¬et al.Adding gemcitabine to paclitaxel/carboplatin combination increases survival in advanced non-small-cell lung cancer£ºResults of a phase II-III study£ÛJ£Ý.Journal of Clinical Oncology£¬2016£¬24(4)£º681-687.
[7]Yal¢“in BP£¬ ÿðþ‰C ahin B.Cost-effectiveness analysis of pemetrexed and gemcitabine treatment for advanced nonsmall cell lung cancer in Turkey£ÛJ£Ý.Turkish Journal of Medical Sciences£¬2016£¬46(1)£º152-158.
[8]Uesaka K£¬Boku N£¬Fukutomi A£¬et al.Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer£ºA phase 3£¬open-label£¬randomised£¬non-inferiority trial (JASPAC 01)£ÛJ£Ý.Lancet£¬2016£¬388(10041)£º248-257.
[9]Sara B£¬Simona OA£¬Paola C£¬et al.Optimal Ki67 cut-off for luminal breast cancer prognostic evaluation£ºA large case series study with a long-term follow-up£ÛJ£Ý.Breast Cancer Research & Treatment£¬2016£¬157(2)£º363-371.
[10]Tian J£¬Xu YY£¬Li L£¬et al.MiR-490-3p sensitizes ovarian cancer cells to cisplatin by directly targeting ABCC2£ÛJ£Ý.Am J Transl Res£¬2017£¬9(3)£º1127-1138.
[11]Nieders¨¹ss-Beke D£¬Puntus T£¬Kunit T£¬et al.Neoadjuvant chemotherapy with gemcitabine plus cisplatin in patients with locally advanced bladder cancer£ÛJ£Ý.Oncology£¬2017£¬93(1)£º36-42.
[12]Borad MJ£¬Reddy SG£¬Bahary N£¬et al.Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer£ÛJ£Ý.Journal of Clinical Oncology£¬2016£¬33(13)£º1475-1481.
[13]Hiraki S£¬Kanesada K£¬Harada T£¬et al.A case of locally advanced gallbladder cancer that developed early multiple liver metastasis after curative resection£¬and achieved long-term partial remission using S-1 and gemcitabine£ÛJ£Ý.Gan To Kagaku Ryoho£¬2016£¬43(12)£º2086-2088.
[14]Erratum£ºThe lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer£ÛJ£Ý.Acta Pharmacologica Sinica£¬2017£¬38(3)£º443-443.
[15]Liu Y£¬Gong W£¬Yang ZY£¬et al.Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer£ÛJ£Ý.Apoptosis£ºAn International Journal on Programmed Cell Death£¬2017£¬22(4)£º544-557.
[16]Burgess J£¬Bolderson E£¬Gray S£¬et al.The overexpression and cleavage of SASH1 by caspase-3 stimulates cell death in lung cancer cells£ÛJ£Ý.Journal of Thoracic Oncology£¬2017£¬12(1)£ºS1158-S1159.
[17]Shui R£¬Yu B£¬Bi R£¬et al.An interobserver reproducibility analysis of Ki67 visual assessment in breast cancer£ÛJ£Ý.Pathology£¬2016£¬48(5)£ºS155-S156.

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