[1]Siegel RL,Miller KD,Jemal A.Cancer statistics,2015 [J].Ca A Cancer Journal for Clinicians,2014,64(1):9.
[2] WANG LJ,LIANG ZX,YU H,et al.Advances in research on driving genes and targeted therapy for lung cancer[J].Int J Respir,2017,37(4):297-301.[王莉洁,梁志欣,喻航,等.肺癌的驱动基因与靶向治疗研究进展[J].国际呼吸杂志,2017,37(4):297-301.]
[3]Travis WD,Brambilla E,Nicholson AG,et al.The 2015 world health organization classification of lung tumors [J].Seminars in Roentgenology,2015,40(2):90-97.
[4]Zhou X,Cai L,Liu J,et al.Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma[J].Oncol Lett,2018,16(1):362-370.
[5]Román M,Baraibar I,López I,et al.KRAS oncogene in non-small cell lung cancer:Clinical perspectives on the treatment of an old target[J].Mol Cancer,2018,17(1):33.
[6] Rao S,Sigl V,Wimmer RA,et al.RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer[J].Genes Dev,2017,31(20):2099-2112.
[7] Ooki A,Dinalankara W,Marchionni L,et al.Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma[J].Oncogene,2018,37(45):5967-5981.
[8]Tessema M,Yingling CM,Picchi MA,et al.ANK1 methylation regulates expression of microRNA-486-5p and discriminates lung tumors by histology and smoking status[J].Cancer Lett,2017(410):191-200.
[9] Yan H,Guan Q,He J,et al.Individualized analysis reveals CpG sites with methylation aberrations in almost all lung adenocarcinoma tissues[J].J Transl Med,2017,15(1):26.
[10]O'Brien TD,Jia P,Caporaso NE,et al.Weak sharing of genetic association signals in three lung cancer subtypes:Evidence at the SNP,gene,regulation,and pathway levels [J].Genome Med,2018,10(1):16.
[11] Heist RS,Sequist LV,Engelman JA.Genetic changes in squamous cell lung cancer:A review[J].Journal of Thoracic Oncology,2012,7(5):924-933.
[12] FU JQ,HA MW.Expression of FGFR1 and VEGF in lung squamous cell carcinoma and its effect on prognosis[J].Med Phil,2016,37(8):67-70.[付俊青,哈敏文.FGFR1和VEGF在肺鳞癌中的表达及其对预后影响[J].医学与哲学,2016,37(8):67-70.]
[13]Flockerzi FA,Roggia C,Langer F,et al.FGFR1 gene amplification in squamous cell carcinomas of the lung:A potential favorable prognostic marker for women and for patients with advanced cancer[J].Virchows Archiv,2018(472):759-769.
[14]Lúcia L Correia,Johnson JA,Mcerlean P,et al.SOX2 drives bronchial dysplasia in a novel organotypic model of early human squamous lung cancer[J].American Journal of Respiratory and Critical Care Medicine,2017,195(11):1494-1508.
[15] Boumahdi S,Driessens G,Lapouge G,et al.SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma[J].Nature,2014,511(7508):246.
[16] Hussenet T,du Manoir S.SOX2 in squamous cell carcinoma amplifying a pleiotropic oncogene along carcinogenesis[J].Cell Cycle,2010,9(8):1480-1486.
[17] Mcgowan M,Hoven AS,Lund-Iversen M,et al.PIK3CA mutations as prognostic factor in squamous cell lung carcinoma[J].Lung Cancer,2017(103):52.
[18] Iwakawa R,Kohno T,Totoki Y,et al.Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing[J].Carcinogenesis,2015,36(6):616.
[19] Won HH,Pietanza MC,Krug LM,et al.Prospective genomic characterization of small cell lung cancer by targeted next generation sequencing[J].Cancer Research,2015(75):610.
[20] George J,Jing SL,Jang SJ,et al.Comprehensive genomic profiles of small cell lung cancer[J].Nature,2015,524(7563):47-53.
[21]Shue YT,Lim JS,Sage J.Tumor heterogeneity in small cell lung cancer defined and investigated in pre-clinical mouse models[J].Transl Lung Cancer Res,2018,7(1):21-31.
[22]Byers LA,Wang J,Nilsson MB,et al.Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1[J].Cancer Discovery,2012,2(9):798.
[23]Kim DW,Kim KC,Kim KB,et al.Transcriptional deregulation underlying the pathogenesis of small,cell lung cancer[J].Transl Lung Cancer Res,2018,7(1):4-20.
[24]Murai F,Koinuma D,Shinozaki-Ushiku A,et al.EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway [J].Cell Discov,2015(1):15026.
[25] Su M,Xiao Y,Tang J,et al.Role of lncRNA and EZH2 interaction/regulatory network in lung cancer[J].J Cancer,2018,9(22):4156-4165.
[26] Zhu QG,Zhang SM,Ding XX,et al.Driver genes in non-small cell lung cancer:Characteristics,detection methods,and targeted therapies[J].Oncotarget,2017,8(34):57680-57692.
[27] CHEN LF,CHEN XY,YU XB.Relationship between driver gene mutation and clinicopathological features in non-small cell lung cancer[J].Chin J Pathol,2016,45(4):221-225.[陈灵锋,陈小岩,俞训彬.非小细胞肺癌驱动基因突变与临床病理特征的关系[J].中华病理学杂志,2016,45(4):221-225.]
[28]ZHANG JJ.Expression and significance of NGAL gene in lung squamous cell carcinoma and lung adenocarcinom[D].Nanchang:Nanchang University School of Medicine,2015.[张金蛟.NGAL基因在肺鳞癌和肺腺癌组织中的表达及意义[D].南昌:南昌大学医学院,2015.]
[29] Lian W,Ouyang Y.CT-guided aspiration lung biopsy for EGFR and ALK gene mutation analysis of lung cancer[J].Oncology letters,2017,13(5):3415-3422.
[30]Schwaederlé MC,Patel SP,Husain H,et al.Utility of genomic assessment of blood-derived circulating tumor DNA(ctDNA) in patients with advanced lung adenocarcinoma[J].Clin Cancer Res,2017,23(17):5101-5111.
[31]Alix-PanabieresC,Pantel K.Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy[J].Cancer Discovery,2016,6(5):479-491.
[32]Normanno N,De LA,Gallo M,et al.The prognostic role of circulating tumor cells in lung cancer[J].Expert Rev Anticancer Ther,2016,16(8):859-867.
[33] Rizzo S,Petrella F,Buscarino V,et al.CT radiogenomic characterization of EGFR,K-RAS,and ALK mutations in non-small cell lung cancer[J].European Radiology,2016,26(1):32-42.
[34]Bak SH,Park H,Lee HY,et al.Imaging genotyping of functional signaling pathways in lung squamous cell carcinoma using a radiomics approach[J].Scientific Reports,2018,8(1):3284.
[35] YANG Y,HUANG SM,GANG B,et al.Meta-analysis of the diagnostic value of 18F-FDG PET/CT for EGFR gene mutation in non-small cell lung cancer[J].Ulrichs IPD,2018,29(5):448-452.[杨洋,黄世明,刚波,等.18F-FDG PET/CT对非小细胞肺癌EGFR基因突变诊断价值的Meta分析[J].武警医学,2018,29(5):448-452.]
[36] Van Gool MH,Aukema TS,Hartemink KJ,et al.FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC[J].World Journal of Radiology,2014,6(7):392-398.
[37] Wang S,Song Y,Yan F,et al.Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors[J].Frontiers of Medicine,2016,10(4):383-388.
[38] Yang JC,Ahn MJ,Kim DW,et al.Osimertinib in pretreated T790M-positive advanced non-small-cell lung cancer:AURA study phase Ⅱ extension component[J].J Clin Oncol,2017,35(12):1288.
[39]Kannan S,Venkatachalam G,Lim HH,et al.Conformational landscape of Epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket[J].Chemical Science,2018,9(23):5212-5222.
[40] Jia Y,Yun CH,Park E,et al.Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors[J].Nature,2016,534(7605):129-132.
[41] Shaw AT,Ou SH,Bang YJ,et al.Crizotinib in ROS1-rearranged non-small-cell lung cancer[J].N Engl J Med,2014,371(21):1189-1197.
[42] Lu S,Zhang J,Ye M,et al.Economic analysis of ALK testing and crizotinib therapy for advanced non-small-cell lung cancer[J].Pharmacogenomics,2016,17(9):985-994.
[43] Kato Y,Ninomiya K,Ohashi K,et al.Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions[J].Cancer Sci,2018,109(10):3149-3158.
[44]Schrank Z,Chhabra G,Lin L,et al.Current molecular-targeted therapies in NSCLC and their mechanism of resistance[J].Cancers(Basel),2018,10(7):224.
[45]Testa U,Castelli G,Pelosi E.Lung cancers:Molecular characterization,clonal Heterogeneity and evolution,and cancer stem cells[J].Cancers(Basel),2018,10(8):248.
[46] Nogova L,Sequist LV,Perez Garcia JM,et al.Evaluation of BGJ398,a fibroblast growth factor receptor 1-3 kinase inhibitor,in patients with advanced solid tumors bearing genetic alterations in fibroblast growth factor receptors:Results of a global phase I,dose-escalation dose-expansion study[J].J Clin Oncol,2017(35):157-165.
[47]Malchers F,Ercanoglu M,Schütte D,et al.Mechanisms of primary drug resistance in FGFR1 amplified lung cancer[J].Clinical Cancer Research,2017,23(18):5527-5536.
[48]Yokota E,Yamatsuji T,Takaoka M,et al.Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma[J].Oncotarget,2017(61):103063-103076.
[49] Shi R,Li M,Raghavan V,et al.Targeting the CDK4/6-Rb pathway enhances response to PI3K inhibition in PIK3CA mutant lung squamous cell carcinoma[J].Clinical Cancer Research,2018,24(23):5990-6000.
[50] Gadgeel SM.Targeted therapy and immune therapy for small cell lung cancer[J].Current Treatment Options in Oncology,2018,19(11):53.