|Table of Contents|

Effects and adverse reactions of ifosfamide combined with cis-platinum and pegylated liposomal doxorubicin on osteosarcoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
310-313
Research Field:
Publishing date:

Info

Title:
Effects and adverse reactions of ifosfamide combined with cis-platinum and pegylated liposomal doxorubicin on osteosarcoma
Author(s):
Song Zhenguo1Zhang Peng2Wang Weiguo1Shao Qingping1
1.Department of Pharmacy;2.Department of Bone and Soft Tissue,Affiliated Cancer Hospital of Zhengzhou University,Henan Zhengzhou 450008,China.
Keywords:
pegylated liposomal doxorubicinifosfamidecis-platinumosteosarcomacurative effectadverse reaction
PACS:
R738.1
DOI:
10.3969/j.issn.1672-4992.2020.02.030
Abstract:
Objective:To investigate the effects and adverse reactions of ifosfamide combined with cis-platinum and pegylated liposomal doxorubicin on osteosarcoma.Methods:36 patients with osteosarcoma were selected.They received pegylated liposomal doxorubicin 20 mg/m2,ivgt d1,ifosfamide 2.0 g/m2,ivgt d1~5,cis-platinum 80 mg/m2,ivgt d8,repeatedly every 21 days.Surgery was performed during chemotherapy.Results:32 patients completed 8 cycles of chemotherapy.25 survived up to July,2018,while 22 obtained tumor free survival.The median tumor-free survival was 40.2 months(22.5~57.3 months).Grade 3/4 adverse reactions include 6 leukopenia(16.7%),granulocytosis(22.2%),2 anemia(2.8%) and 1 vomiting(5.6%).The MSTS 93 score for long-term survival patients was 16~30 with the average of 22.2 and excellent rate of 80.0%.SF-36 scale showed a lower score for vitality.Conclusion:Combination therapy comprising ifosfamide,cis-platinum and pegylated liposomal doxorubicin was effective and well tolerated as first-line treatment for patients with osteosarcoma,which is worthy of further research.

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Last Update: 2019-11-29