|Table of Contents|

Expression and clinical significance of STAT3 and Nanog genes in esophageal cancer tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
227-231
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of STAT3 and Nanog genes in esophageal cancer tissues
Author(s):
Wang Jian1; Xu Jun1; Li Xuewei1; Xia Zhiqing2
1.Department of General Surgery,Second Hospital of Shanxi Medical University,Shanxi Taiyuan 030002,China;2.Department of General Surgery,Shanxi Cancer Hospital,Shanxi Taiyuan 030013,China.
Keywords:
signal transducer and activator of transcription 3; esophageal cancer; median survival time
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2020.02.011
Abstract:
Objective:To investigate the expression and clinical significance of STAT3 and Nanog genes in esophageal carcinoma.Methods:100 patients with esophageal cancer were selected as the research subjects.The expression of STAT3 and Nanog in cancer tissues and adjacent tissues were detected,and clinical and pathological parameters were recorded and followed up.Results:STAT3 and Nanog proteins were mainly expressed in the nucleus and expressed in a small number of adjacent tissues.The positive rate of STAT3 (56.0%,56/100) in cancer tissues was significantly higher than that in paracancerous tissue (30.0%,30/100),and the positive rate of Nanog (74.0%,74/100) was significantly higher than that of paracancerous tissue (18.0%,18/100).The degree of differentiation,lymph node metastasis and distant metastasis were the independent risk factors affecting the positive expression of STAT3 and Nanog,and the lower the degree of differentiation,the more late the N staging,the M staging,the higher the positive rate of STAT3 and Nanog.The molecular weights of STAT3 and Nanog were 88 kDa and 66 kDa,respectively,and the expression intensity in cancer tissues was significantly higher than that in adjacent tissues.The median survival time of the STAT3 (+) group and the STAT3 (-) group was 9.5 months and 17.8 months respectively.The median survival time of the Nanog (+) group and the Nanog (-) group was 7.8 months and 16.6 months respectively,and the difference was statistically significant.Conclusion:The positive rate of STAT3 and Nanog in esophageal cancer patients is high,which is related to tumor differentiation and TNM staging.Compared with negative patients,the median survival time of patients with positive expression of STAT3 and Nanog is significantly shorter than that of negative ones,which can be used as a potential prognostic factor for patients.

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山西省卫生计生委科研课题计划项目（编号：2015048）
Last Update: 2019-11-29