|Table of Contents|

Correlation study of ABCB1 C3435T and G2677AT gene morphology with patient' s cancerous pain perception

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
134-138
Research Field:
Publishing date:

Info

Title:
Correlation study of ABCB1 C3435T and G2677AT gene morphology with patient' s cancerous pain perception
Author(s):
Li Na1Zhang Shengmao2Li Min1Yang Lizhen1Liu Junqing1Tian Shaopeng1Li Shuwen3
1.Pain Treatment Department,Hohhot First Hospital,Inner Mongolia Hohhot 010030,China;2.Anesthesiology Department,Inner Mongolia People's Hospital,Inner Mongolia Hohhot 010030,China;3.Medical Science Department,Inner Mongolia Medical University,Inner Mongolia Hohhot 010030,China.
Keywords:
ABCB1 C3435TABCB1 G2677ATgene morphologycancerous paincorrelation
PACS:
R730.58
DOI:
10.3969/j.issn.1672-4992.2020.01.032
Abstract:
Objective:To study the correlation of ATP-binding cassette sub-family B member-1(ABCB1)C3435T and G2677AT gene morphology with patient's cancerous pain perception.Methods:The specimens about 185 malignant tumor patients treated from September 2016 to September 2018 in our hospital were histopathologically analyzed.116 cancerous pain patients(pain group)and 69 painless patients(painless group)were involved.The three-dimensional polyacrylamide DNA chip technique was used to test the ABCB1 C3435T and G2677AT genetic typing conditions.The correlation of ABCB1 C3435T and G2677AT gene morphology with patient's cancerous pain perception was analyzed.Results:The wild type,heterozygous type and mutant type of C3435T gene distribution frequency between the two groups showed no statistically significant difference(P>0.05).The wild type,heterozygous type and mutant type of G2677AT gene distribution frequency between the two groups showed no statistically significant difference(P>0.05).C3435T and G2677AT genotype distribution frequency among patients with varying degrees cancerous pain showed no statistically significant difference(P>0.05).Numerical rating scale(NRS)scores among cancerous pain patients with different C3435T and G2677AT genotypes showed no statistically significant difference (P>0.05).NRS scores among patients with the same C3435T and G2677AT genotypes showed no statistically significant difference(P>0.05).Conclusion:ABCB1 C3435T and G2677AT gene morphology have no direct correlation with patient's cancerous pain perception.It is to be further explored in clinical practice.

References:

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内蒙古自然科学基金项目(编号:2017MS08126)
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