|Table of Contents|

Efficacy of chemotherapy combined with and without Bortezomib in the treatment of multiple myeloma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
117-120
Research Field:
Publishing date:

Info

Title:
Efficacy of chemotherapy combined with and without Bortezomib in the treatment of multiple myeloma
Author(s):
Huang Yuan1; Zhang Hui2
1.School of Public Health，Kunming Medical University，Yunnan Kunming 650500，China；2.School of Public Health，Sun Yat-sen University，Guangdong Guangzhou 510080，China.
Keywords:
multiple myeloma; bortezomib; chemotherapy; efficacy
PACS:
R733.3
DOI:
10.3969/j.issn.1672-4992.2020.01.029
Abstract:
Objective：To compare the efficacy of chemotherapy combined with and without Bortezomib in the treatment of multiple myeloma(MM).Methods：We retrospectively analyzed 155 cases of multiple myeloma，who were divided into two groups：The Bortezomib group(chemotherapy combined with Bortezomib，containing 78 patients)and the control group(chemotherapy combined without Bortezomib，containing 79 patients).All patient completed three and more courses of treatment.The endpoint was the courses of treatment taken to reach a stable phase of disease.The t test was used to analyze the continuous variables and χ2 test was used to analyze the categorical variables.Results：There were no significant differences in the baseline of gender，age，newly diagnosed or recurrence，DS stage，ISS stage，disease type，renal function before treatment between two groups(P>0.05).The objective response rate(ORR)and complete response rate(CR+nCR)of the Bortezomib group were 71.8% and 44.9%，which were significantly higher than those of the control group respectively(50.6% and 28.6%)(P=0.007,P=0.035).The mean of treatment courses taken by the Bortezomib group were two courses less than those taken by the control group.The sub-group analysis showed the group with Bortezomib in all courses of treatment didn't improve the ORR and CR+nCR(P>0.05).However，there were four courses less when taking the Bortezomib therapy in all courses of treatment.Conclusion：Compared with chemotherapy combined without Bortezomib，the therapy combined with Bortezomib was more effective and faster to reach a stable phase of disease，which may be a better treatment option for MM patients.

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Memo

Memo:
National Natural Science Foundation of China(No.71704194);国家自然科学基金项目（编号：71704194）；广东省自然科学基金项目（编号：2016A030313204）
Last Update: 1900-01-01