|Table of Contents|

The effect of discontinuation of imatinib in the treatment of chronic myeloid leukemia in pregnancy on fetus and patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
113-116
Research Field:
Publishing date:

Info

Title:
The effect of discontinuation of imatinib in the treatment of chronic myeloid leukemia in pregnancy on fetus and patients
Author(s):
Liang ShunyuPan YaozhuYang KeBai Hai
Department of Hematology,the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army,Gansu Lanzhou 730050,China.
Keywords:
imatinibchronic myeloid leukemiapregnant
PACS:
R733.7
DOI:
10.3969/j.issn.1672-4992.2020.01.028
Abstract:
Objective: To analyze the effect of discontinuation of imatinib in the treatment of chronic myeloid leukemia in pregnancy on fetus and patients.Methods:Retrospect the impact of 21 CML patients complicated with pregnancy in our department during receiving imatinib.Results:Of the 21 CML patients who received imatinib,6 were accidentally pregnancies and 15 were planed to become pregnant.Female patients with fertility will need to achieve hematologic or cytological remission for at least 2 years,stop imatinib 1 month before conception and 3 months before pregnancy.Male patients stop receiving imatinib 1 month before their wife become pregnant.All patients who were accidentally conceived did not stop taking imatinib during pregnancy.Without 2 spontaneous abortions and 3 elective abortions.All 21 patients produced 9 male and 7 female infants(1 with hypospadias and 1 mild cerebral edema).Conclusion:CML patients receiving imatinib are encouraged to have planned pregnancy,and imatinib may cause spontaneous abortion or congenital anomalies in patients who are unintended during treatment.

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Memo

Memo:
National Natural Science Foundation of China(No.81372132);国家自然科学基金(编号:81372132);甘肃省青年科技计划(编号:17JR5RA326)
Last Update: 1900-01-01