|Table of Contents|

Clinical observation of endostar combined with docetaxel sequential intraperitoneal perfusion in the treatment of gastric carcinoma with malignant ascites

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
98-101
Research Field:
Publishing date:

Info

Title:
Clinical observation of endostar combined with docetaxel sequential intraperitoneal perfusion in the treatment of gastric carcinoma with malignant ascites
Author(s):
Li ChenghuiLong TingtingWang ChaoChu QinyunDuan Aixiong
Department of Oncology,Affiliated Anqing Hospital of Anhui Medical University,Anhui Anqing 246000,China.
Keywords:
recombinant human endostain/endostardocetaxelmalignant ascitesgastric carcinoma
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2020.01.025
Abstract:
Objective:To retrospectively analyse the efficacy and adverse effects of endostar combined with docetaxel sequential intraperitoneal perfusion in the treatment of gastric carcinoma with malignant ascites.Methods:72 cases of gastric cancer patients with ascites had received second-line chemotherapy and above.The observation group(35 cases) was trcated with 45 mg of endostar combined with docetaxel (Calculated according to 35 mg/m2 d1,d5) sequential intraperitoneal perfusion after 1 cycles.The control group (37 cases) was treated with docetaxel (Calculated according to 35 mg/m2 d1,d5) intraperitoneal perfusion for 1 cycle.The effective probability of control of ascites,the probability of Improvement in quality of life,the control time of ascites and the adverse reactions were recored.Results:The effective rate of ascites control was 71.43% in the observation group and 48.65% in the control group.There was a statistical difference between the two groups(P=0.049).The improvement rate of KPS was 77.14% in the observation group and 54.05% in the control group.There was a statistical difference between the two groups(P=0.04).The control time of ascites in the observation group was 8~90 days,and the median control time was 44 days.In the control group,the control time of ascites was 5~66 days and the median control time was 28 days.The control time of the two groups was significantly different(P=0.048).The incidence of adverse reactions above III was low,no treatment-related deaths,and there was no statistical difference between the two groups of adverse reactions,P>0.05.Conclusion:For the poor PS score of gastric cancer patients with malignant ascites,endostar combined with docetaxel sequential intraperitoneal therapy is a good treatment.It can control ascites well and obviously improve the quality of life with no obvious adverse reactions.This scheme is safe and effective and is worthy of further promotion in clinical practice.

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