|Table of Contents|

Risk factors of urethral carcinoma after radical resection of superficial bladder cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
94-98
Research Field:
Publishing date:

Info

Title:
Risk factors of urethral carcinoma after radical resection of superficial bladder cancer
Author(s):
Cao ShuqinLi HaiyanMa Xiaoping
Oncology Department,Qinghai Red Cross Hospital,Qinghai Xining 810000,China.
Keywords:
superficial bladder cancerurethral carcinomarisk factors analysis
PACS:
R737.14
DOI:
10.3969/j.issn.1672-4992.2020.01.024
Abstract:
Objective:To investigate the risk factors of urethral carcinoma after radical resection of superficial bladder cancer.Methods:The clinical data of 60 patients with superficial bladder cancer who underwent RC in our hospital from January 2010 to February 2015 were retrospectively analyzed.According to the postoperative urethral cancer,10 cases were collected as urethral cancer group,50 cases were collected as non urethral cancer group.The differences of clinical data between the two groups were compared and the independent risk factors of urethral cancer occurrences following RC in patients with pathological superficial bladder cancer were analyzed by Cox regression.Results:In this group,10 cases(16.67%)had urethral cancer,and the pathological types were all urethral cancer.Among 6 cases of non-orthotopic neobladder there were 4 cases of bilateral ureterocostomy and 2 cases of Bricker operation.The tumor lesions of 23 cases was ≥2,and the histological grade of 17 cases was highly differentiated urothelial carcinoma.The proportion of patients without preoperative perfusion chemotherapy and the number of invading prostate in urethral cancer group were higher than those in non-urethral cancer group(P<0.05).Cox regression analysis showed that prostate urethral involvement (HR=1.958,95%CI:1.151~3.331) and non-orthotopic neobladder (HR=2.123,95%CI:1.200~3.756) were independent risk factors of urethral cancer following RC (P<0.05).Intravesical instillation before operation (HR=0.645,95%CI:0.336~0.863) was the protective factor of the urethral cancer (P<0.05).Conclusion:Prostate urethral involvement and non-orthotopic neobladder are independent risk factors of urethral cancer following RC,while intravesical instillation before operation is the protective factor of the urethral cancer,so urethrectomy for patients with high risk factors and intravesical instillation before operation were important.

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Last Update: 1900-01-01