|Table of Contents|

Expression of circulating miR-17-5p in gastric cancer patients and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
92-94
Research Field:
Publishing date:

Info

Title:
Expression of circulating miR-17-5p in gastric cancer patients and its clinical significance
Author(s):
Wang Jun1; Ling Xin2; Li Wen2; Zhang Dongxin1
1.Department of Clinical Laboratory，Shandong Rongjun General Hospital，Shandong Jinan 250013，China;2.Department of Clinical Laboratory，the Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Shandong Jinan 250014，China.
Keywords:
miR-17-5p; gastric cancer; qRT-PCR; biomarkers in serum
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2020.01.023
Abstract:
Objective：To explore the expression of miR-17-5p in the serum of gastric cancer patients and its clinical significance．Methods：Expression of miR-17-5p in serum of 54 gastric cancer patients and 54 healthy control persons was analyzed by qRT-PCR.Statistical analysis was performed to analyze the association between the miR-17-5p and the clinic pathological parameter.Results：The results of qRT-PCR showed that the circulating miR-17-5p was significantly down-regulated in the serum of the patients with gastric cancer patients compared to the normal controls．And the decreased expression of miR-17-5p was associated with tumor size，lymph node metastasis and TNM stage，but not significantly correlated with age，gender and tumor differentiation.Conclusion：Circulating miR-17-5p expression is significantly down-regulated in serum of gastric cancer patients，and is a promising diagnostic and prognostic biomarker for gastric cancer patients.

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