|Table of Contents|

A report for primary hepatic amyloidosis and literature review

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
75-78
Research Field:
Publishing date:

Info

Title:
A report for primary hepatic amyloidosis and literature review
Author(s):
Tang Zhengyi; Liu Siqi; Shao Xue; Zhang Chuanhui; Jin Zhenjing; Yang Lanlan
Department of Hepatopancreatobiliary，the Second Hospital，Jilin University，Jilin Changchun 130041，China.
Keywords:
hepatic amyloidosis; hepatomegaly; liver biopsy
PACS:
R730.4
DOI:
10.3969/j.issn.1672-4992.2020.01.019
Abstract:
Objective：To report a case of primary hepatic amyloidosis，so as to improve perception of the disease and reduce misdiagnosis and mistherapy of the disease.Methods：Discuss and analyze the clinical manifestations，diagnosis，treatment and prognosis of primary hepatic amyloidosis with a case report diagnosed by pathology of our hospital in April 2015 and review the national and international literature.Results：It was a patient with right upper quadrant pain，abdominal distension and hepatauxe who had gotten splenectomy one year ago in our hepatopancreatobiliary surgery department.The spleen pathology showed old splenic rupture including hemorrhage，hematoma，splenic white pulp atrophy and splenic red pulp hyaline degeneration.Liver function displayed high ALP，low albumin and high globulin.Abdominal CT showed hepatomegaly with liver parenchyma inhomogeneous enhancement and cholecystolithiasis.Hepatic biopsy showed hepatic cords degeneration and necrosis，inflammatory cell infiltration，pink with no structural material between liver cells in hepatic cords.Immunohistochemistry showed CD34(-)，Congo red staining(+).Conclusion：Lack of experience of diagnosis and treatment of Primary Hepatic Amyloidosis is one of the reasons of misdiagnosis of the disease.The disease characterized by abdominal pain and hepatomegaly is easily misdiagnosed as fatty liver disease，liver cirrhosis or primary liver cancer.We must maintain keen vigilance when we found a patient with hepatomegaly and significantly increased ALP，but unevenness with other liver function biochemical criterion，especially multiple organs involved.The only way to diagnose is liver biopsy，but hemorrhage as complication is severe.

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