|Table of Contents|

Association of miR-27a(rs895819)polymorphism with lung cancer risk in non-smoking female of Beijing area

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
69-72
Research Field:
Publishing date:

Info

Title:
Association of miR-27a(rs895819)polymorphism with lung cancer risk in non-smoking female of Beijing area
Author(s):
Jin Qing’e; Wu Shanna; Zhang Yaxin; Su Jianrong
Department of Clinical Laboratory，Capital Medical University Affiliated Beijing Friendship Hospital，Beijing 100050，China.
Keywords:
pre-miR-27a; non-smoking female lung cancer; single nucleotide polymorphism; genetic susceptibility
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.01.017
Abstract:
Objective：To investigate the association of miR-27a rs895819 variant and risk of non-smoking female lung cancer(LC)in a Chinese Han population.Methods：In the case-control study，genotype distribution of rs895819 in 90 LC cases and 97 age-matched healthy check-up controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay(PCR-RFLP).The correlation of rs895819 SNPs with the susceptibility to LC was analyzed.Results：The frequencies of the GG genotype and G allele of rs895819 variant were significantly higher in the LC group than that in the control group(P=0.047,P=0.016).Genotype AG+GG showed a significantly increased risk of LC(OR=1.82，95%CI=1.01～3.28，P=0.038).There was significant difference between LC and control group for cooking oil fume exposure(P=0.035).However，The combination of rs895819 SNP and cooking oil fume exposure had no significant influence on non-smoking female LC risk.No significant association was found between rs895819 SNP and clinical pathological parameters by stratified analysis.Conclusion：Allele G within rs895819 was significantly associated with lung cancer risk in a Han non-smoking female population of Northern China.

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